Products

OptimMRI
Rebrain
Neurology AI
OptimMRI by Rebrain is an AI-powered Software as a Medical Device (SaMD) that revolutionizes neurosurgical target planning. It combines advanced AI algorithms with MRI sequences to provide neurosurgeons with optimal targets for Deep Brain Stimulation (DBS) and lesioning techniques for conditions like Parkinson's Disease and Essential Tremor.

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About Rebrain

Rebrain, also known as RebrAIn, is a healthcare AI company specializing in precision neurosurgery. The company develops advanced targeting technology for Deep Brain Stimulation (DBS) procedures, primarily addressing neurodegenerative conditions such as Parkinson’s disease (PD) and essential tremor (ET). Their core offering, the Optim MRI software, utilizes sophisticated artificial intelligence algorithms combined with a collaborative health data registry to accurately identify optimal brain regions for surgical intervention.

This AI-driven solution aims to significantly enhance the efficiency, safety, and standardization of neurosurgical workflows. By providing precise, millimetric MRI-guided targeting, Rebrain’s technology seeks to simplify complex patient-specific neurosurgery, potentially reducing operative time and improving patient outcomes. The Optim MRI and OptimDBS software have received both CE Mark and FDA 510(k) clearance, underscoring their regulatory compliance and clinical readiness.

For physicians, Rebrain’s technology offers a streamlined approach to neuromodulation planning, potentially expanding access to cutting-edge neurological care for a greater number of patients worldwide. Beyond its current applications in DBS, the company is actively exploring the extension of its AI platform to other minimally invasive neurosurgical techniques, including radiosurgery and focused ultrasound, further demonstrating its commitment to advancing precision medicine in neurology.

Focus Areas

Precision neurosurgery Deep Brain Stimulation (DBS) lesioning techniques MR-guided focused ultrasound (MRgFUS) radiosurgery Parkinson's disease Essential Tremor AI-guided targeting medical imaging neuromodulation planning Software as a Medical Device (SaMD)

Business Intelligence

Key InvestorsKarista, Nouvelle Aquitaine CO-Investissement (NACo), Aquitaine Science Transfert (AST), Gold Track, Les Startups de la PTIB, M CAPITAL
PartnershipsMedical Horizons S.r.l. (Italy), Duke University, University of Virginia (UVA), Pamplona, UCLA
TechnologyCloud-based SaaS (Software as a Service) solution (Optim MRI), supervised AI algorithms, health data exchange platform, MRI sequences for targeting, Software as a Medical Device (SaMD)
FDA Clearances2 cleared products (estimated)

What Physicians Need to Know

Precision Neurosurgery & Neuromodulation Planning
Rebrain specializes in precise brain targeting for neurosurgical procedures, including Deep Brain Stimulation (DBS) and various lesioning techniques. Their OptimMRI software streamlines the pre-surgical planning process by providing augmented neuromodulation planning.
Deep Brain Stimulation (DBS)
The company offers precise targeting technology for DBS, specifically for conditions like Parkinson's disease (targeting the Subthalamic Nucleus - STN) and Essential Tremor (targeting the Ventral Intermediate Nucleus - VIM). Their FDA-cleared machine learning models assist in accurately identifying optimal targets for electrode placement.
Lesioning Techniques
Rebrain's OptimMRI software includes advanced machine learning models to aid in targeting specific brain regions for lesioning techniques such as MR-guided focused ultrasound (MRgFUS) and radiosurgery.
Focus on Movement Disorders
Their technology is specifically designed to enhance patient outcomes for Parkinson's disease and Essential Tremor by providing millimetric MRI-guided targeting of the relevant brain regions.
AI-Guided Targeting & Medical Imaging
Rebrain leverages supervised AI algorithms and standard T1, 1.5 T MRI images to semi-automatically recognize 18 anatomical structures per hemisphere, predict optimal targets, and mark them on the MRI for surgical planning.
Software as a Medical Device (SaMD)
Rebrain's core products, OptimMRI and OptimDBS, are CE Marked and FDA 510(k) cleared Software as a Medical Device (SaMD), ensuring regulatory compliance and clinical validation.
Physician Tip

For physicians, Rebrain's AI-guided targeting offers a significant advancement in neurosurgical planning. It promises enhanced precision and accuracy in identifying optimal targets for DBS and lesioning procedures, which can lead to improved patient outcomes for Parkinson's disease and Essential Tremor. The streamlined and standardized workflow, coupled with the potential to reduce reliance on intraoperative electrophysiology and enable surgery under general anesthesia, can significantly improve efficiency and patient comfort. The FDA and CE clearances provide a strong assurance of the technology's reliability and safety, making it a valuable tool for expanding access to advanced neuromodulation therapies.

Rebrain's service operates as a cloud-based platform. Physicians upload DICOM compatible MR images, which are then processed by Rebrain's AI algorithms. The platform returns marked MRIs with predicted targets to the healthcare centers for surgical planning. This requires a secure health data exchange platform and compatibility with existing medical imaging systems. The data is hosted on HDS (Health Data Hosting) certified servers to ensure compliance with data privacy regulations like GDPR.

Products by Rebrain

1 product in the directory

OptimMRI
Rebrain
Neurology AI
OptimMRI by Rebrain is an AI-powered Software as a Medical Device (SaMD) that revolutionizes neurosurgical target planning. It combines advanced AI algorithms with MRI sequences to provide neurosurgeons with optimal targets for Deep Brain Stimulation (DBS) and lesioning techniques for conditions like Parkinson's Disease and Essential Tremor.

What the Web Says

Rebrain (also known as Rebrain.com or Rebrain LLC) appears to be a company with a focus on IT recruitment and potentially educational services, though information is somewhat fragmented across different platforms. Reviews suggest a mixed bag, with some positive experiences regarding career opportunities and skill development, while others point to issues with management, communication, and job security. The company's presence on major review sites like G2, Capterra, and Glassdoor is limited or non-existent for direct reviews of 'Rebrain' as a product or employer, making a comprehensive assessment challenging.

Overall: Mixed

Strengths

  • Opportunities for career growth and skill development (from limited Glassdoor-like comments)
  • Exposure to diverse projects and technologies (inferred from IT recruitment context)
  • Potential for remote work flexibility (common in IT recruitment)
  • Helpful in finding job opportunities for some candidates (from limited Reddit discussions)

Limitations

  • Lack of transparency and poor communication from management (from limited Glassdoor-like comments)
  • Issues with job security and sudden terminations (from limited Glassdoor-like comments)
  • Unclear company structure and roles (inferred from fragmented information)
  • Limited direct reviews on major platforms like G2, Capterra, and Glassdoor for 'Rebrain' specifically
  • Some users report being spammed by recruiters (from Reddit)
  • Difficulty in getting clear information about services or products

Based on reviews from: Glassdoor (limited mentions/reviews for 'Rebrain' or similar entities), Reddit (various threads discussing 'Rebrain' as a recruiter or platform), G2 (no direct product or company reviews found for 'Rebrain'), Capterra (no direct product or company reviews found for 'Rebrain'), Healthcare IT reviewers (no specific reviews found for 'Rebrain' in this context)

Last updated: 2026-07-20

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Press & Coverage

Business Wire
RebrAIn Receives Second FDA 510(k) Clearance to Optimize Targeting in Stereotactic and Functional Neurosurgery for Both Deep Brain Stimulation and Lesioning Techniques (MRgFUS and Radiosurgery)
RebrAIn has received its second FDA 510(k) clearance for its OptimMRI software, which now includes a new machine learning model to assist in targeting the infero-lateral part of the VIM for lesioning techniques such as MRgFUS and Radiosurgery. This expands the software's capabilities for deep brain stimulation (DBS) and lesioning techniques for neurological disorders like Parkinson's disease and essential tremor.
2024-08
Focused Ultrasound Foundation
RebrAIn Receives FDA Clearance for Expanded Targeting - Focused Ultrasound Foundation
RebrAIn's OptimMRI software received its second FDA 510(k) clearance, expanding its capabilities to include the inferolateral part of the ventral intermediate (VIM) nucleus region of the brain for targeting in Parkinson's disease and essential tremor. This clearance is a significant step for RebrAIn's growth and strategic transformation in the US market.
2024-09
BioWorld
Rebrain's brain targeting AI secures MDR CE mark | BioWorld
Rebrain SAS's OptimMRI platform received European Medical Device Regulation (MDR) CE mark certification, authorizing its full suite of services for commercialization across European markets. This certification covers both deep brain stimulation (DBS) and lesioning techniques for Parkinson's disease and essential tremor.
2025-05
Karista VC
RebrAIn completes u20ac3.7M financing seed round - Karista VC
RebrAIn closed a u20ac3.7 million seed round led by Karista, with participation from Nouvelle Aquitaine CO-Investissement (NACo) and existing investors. This funding will accelerate the global commercial growth of RebrAIn's precision neurosurgery AI-powered solutions.
2024-03
Rebrain
Rebrain x Worldwide Dystonia Research Center
Rebrain announced a strategic collaboration with an International University Hospital to develop next-generation data-driven models for personalized deep brain stimulation (DBS) targeting in dystonia. This partnership expands Rebrain's clinical applications beyond Parkinson's disease and essential tremor to include dystonia and severe pediatric dystonia.
2026-05
Rebrain
Rebrain unveils its identity: a strong vision for the future of assisted neurosurgery
Rebrain officially launched its new identity, emphasizing its commitment to improving the precision of neurosurgical procedures and positively impacting patients' lives through innovation. This marks a new stage in the company's development, focusing on a strong vision for the future of assisted neurosurgery.
2026-05
Rebrain
Rebrain publishes OPTIVIM trial results in Neurosurgery
Rebrain published the results of its OPTIVIM trial in Neurosurgery, showcasing an innovative and automated method for deep brain stimulation (DBS) targeting. The service utilizes a machine learning model trained on data from successfully treated patients to compute optimal DBS target coordinates using standard 3D T1 MRI.
2025-12
Rebrain
La Tribune Features RebrAIn's AI Solutions for Parkinson's Disease Treatment
La Tribune featured RebrAIn's AI solutions for Parkinson's Disease treatment, highlighting the company's supervised AI-driven platform that enhances the precision of Deep Brain Stimulation (DBS). This innovative approach aims to make neurosurgical procedures safer and more effective for patients.
2026-05

Frequently Asked Questions

Rebrain's core technology, primarily its OptimMRI and OptimDBS software, leverages supervised AI algorithms combined with T1 MRI sequences to precisely identify optimal brain targets for neurosurgical procedures. This AI-guided targeting aims to simplify and standardize complex procedures, enhancing millimetric precision for conditions such as Parkinson's disease and Essential Tremor.
Rebrain's SaMD supports Deep Brain Stimulation (DBS) and lesioning techniques, including MR-guided focused ultrasound (MRgFUS) and radiosurgery. These techniques are applied to treat motor symptoms of neurological disorders like Parkinson's disease (targeting STN) and Essential Tremor (targeting VIM).
Rebrain's OptimMRI and OptimDBS software are CE Marked and FDA 510(k) cleared as Software as a Medical Device (SaMD). The company has also achieved MDR certification and adheres to data protection regulations such as GDPR and HIPAA, with data hosted on HDS (Health Data Hosting) certified servers.
Rebrain's AI-guided planning streamlines the pre-surgical process, potentially reducing operating room time and allowing for procedures under general anesthesia, which can be less traumatic for patients. This standardization and enhanced precision aim to improve patient outcomes, reduce risks, and expand access to treatment.
Rebrain operates on a Software as a Service (SaaS) model, where its cloud-based platform processes MRI images to provide AI-predicted targets for surgical planning. While specific pricing details are not publicly disclosed, the SaaS model typically involves subscription-based access for healthcare providers.
Rebrain's service is designed for seamless integration into neurosurgeons' workflows, streamlining the pre-surgical planning process from T1 MRI upload to marked MRI delivery for surgical planning. They aim to provide a standardized technique with an efficient workflow, implying support for integration and usage.
Founded in 2021, Rebrain is a funded startup that recently closed a u20ac3.7 million seed round in March 2024, indicating financial stability and growth. They are actively expanding their reach, collaborating with major neurosurgery centers like Duke University, UVA, Pamplona, and UCLA, and have a partnership with Medical Horizons in Italy.

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