Products

SubtleHD (1.x)
Subtle Medical
Radiology & Imaging AI
SubtleHD(MR)™ is a cutting-edge AI software that dramatically improves image quality and enables up to 80% faster scans on any existing MRI machine, enhancing diagnostic confidence and operational efficiency.
SubtleSYNTH (1.x)
Subtle Medical
Radiology & Imaging AI
SubtleSYNTH by Subtle Medical is an AI-powered software that generates synthetic STIR MRI images from existing T1 and T2 weighted contrasts with zero acquisition time, improving efficiency and patient experience in medical imaging.
AiMIFY (1.x)
Subtle Medical
Neurology AI
AiMIFY (1.x) by Subtle Medical is an AI-powered software that enhances brain MRI scans by amplifying contrast to improve the visualization of small and poorly enhanced lesions, sold by Bracco.

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About Subtle Medical

Subtle Medical is a leading healthcare AI company specializing in applying deep learning to medical image acquisition to enable faster, safer, and smarter medical imaging. Their vendor-neutral software solutions integrate seamlessly with existing MRI, PET, and CT scanners, enhancing image quality and optimizing radiology workflows without requiring costly hardware upgrades.

For physicians, Subtle Medical’s AI-powered tools, such as SubtleMR™, SubtlePET™, SubtleSYNTH™, and AiMIFY™, aim to significantly improve diagnostic confidence by providing ultra-clear images and enabling accelerated scan protocols (up to 80% faster for MRI and 25% for PET). This allows for increased patient throughput, reduced wait times, and a better patient experience due to shorter exam durations and the potential for lower radiation and contrast agent dosages. The company holds multiple FDA clearances and CE Mark approvals, with its solutions deployed on over 1000 scanners globally, impacting millions of patients annually.

Focus Areas

AI-powered medical image acquisition image enhancement image synthesis denoising sharpening reduced contrast agent dosage faster scan times improved image quality workflow optimization MRI PET CT SPECT angiography

Business Intelligence

Key InvestorsFusion Fund, EnvisionX Capital, BRV Capital, Ignite Innovation, Samsung Ventures, 3E Bioventures Capital, Data Collective, Delta Capital, Tsingyuan Ventures, Crista Galli Ventures, Nina Capital, Bessemer Venture Partners, Zhenfund (Momentor Ventures), Breyer Capital, Baidu Ventures, Altalurra Ventures, Caixa Capital, Next Level Ventures, Scale Asia Ventures, Alumni Ventures, Berkeley SkyDeck Fund, BootstrapLabs, James Hardiman
PartnershipsBracco Imaging (AiMIFY™), Bayer Pharmaceuticals (SubtleGAD™ clinical trial), Siemens Healthineers, GE Healthcare, Philips (China), RadNet, UCSF, Hoag Hospital, Mount Sinai, SickKids, DASA, Tiantan Hospital, Middlesex Hospital, SimonMed Imaging, Rezolut, Strategic Radiology, Getz Healthcare, 626
TechnologyDeep learning, AI, advanced generative models, vendor-neutral software solutions, cloud-native (implied)
FDA Clearances9 cleared products (estimated)

What Physicians Need to Know

AI-Powered Image Acquisition & Speed
Subtle Medical's solutions enable significantly faster scan times, up to 80% for MRI and faster low-count PET imaging. This leads to increased patient throughput and improved operational efficiency, allowing more patients to be served.
Advanced Image Enhancement & Quality
Through AI-powered denoising and sharpening (e.g., SubtleHDu2122), Subtle Medical delivers ultra-clear images, improving image quality on both regular and accelerated protocols. This enhances diagnostic confidence for physicians.
Innovative Image Synthesis
SubtleSYNTHu2122 utilizes AI to generate MR imaging contrasts, achieving 100% acceleration and producing synthetic STIR images in zero acquisition time, which are interchangeable with conventionally acquired STIR images.
Reduced Contrast Agent Dosage
SubtleGADu2122 offers AI-powered contrast enhancement, dramatically reducing gadolinium dosage while maintaining diagnostic image quality. Additionally, AiMIFYu2122 (sold by Bracco) selectively amplifies brain lesion visualization with reduced gadolinium doses.
Workflow Optimization & Automation
Solutions like SubtleALIGNu2122 automate brain MR alignment for improved consistency and reduced manual adjustments. Subtle Medical is also developing an AI Imaging Hub for unified infrastructure, image quality checks, naming standardization, and performance insights.
Multi-Modality Support
Subtle Medical provides AI solutions for MRI (SubtleHDu2122, SubtleSYNTHu2122, SubtleALIGNu2122), PET (SubtlePETu2122), and is expanding its benefits into CT imaging.
Physician Tip

For physicians, Subtle Medical's AI solutions offer several key advantages. The primary benefit is **improved diagnostic confidence** through sharper, clearer images and enhanced lesion visualization, even from accelerated or low-dose scans. This is coupled with **faster patient care** due to significantly reduced scan times, which can alleviate patient discomfort, especially for those who struggle to remain still, and reduce wait times for critical imaging procedures. The ability to **reduce contrast agent dosage and potentially radiation dose** makes imaging safer and more patient-friendly. Furthermore, the **optimization and automation of workflow** through features like automated image alignment and future AI Imaging Hub capabilities can streamline reading processes and reduce manual tasks, leading to more consistent studies and less radiologist burnout. Finally, these solutions **extend the lifespan and enhance the performance of existing imaging equipment** without requiring costly new hardware investments, making high-quality imaging more accessible and sustainable.

Subtle Medical's software solutions are designed to be **vendor-neutral**, ensuring compatibility with any OEM, make, model, and most field strengths and contrast types across MRI, PET, and soon CT scanners. They integrate seamlessly into existing radiology workflows and are compatible with Picture Archiving and Communication Systems (PACS). Subtle Medical actively collaborates with industry leaders, including partnerships with Bracco Imaging for AiMIFYu2122, Bayer Pharmaceuticals for SubtleGADu2122, and Telix for SubtlePETu2122. Their technology stack leverages **deep learning and generative AI**, significantly powered by NVIDIA's latest generation GPU architecture, including NVIDIA Hopper GPUs, for efficient model training and deployment. The company also has strategic partnerships, such as with Strategic Radiology, to offer exclusive pricing to its members.

Products by Subtle Medical

5 products in the directory

SubtleHD (1.x)
Subtle Medical
Radiology & Imaging AI
SubtleHD(MR)™ is a cutting-edge AI software that dramatically improves image quality and enables up to 80% faster scans on any existing MRI machine, enhancing diagnostic confidence and operational efficiency.
SubtleSYNTH (1.x)
Subtle Medical
Radiology & Imaging AI
SubtleSYNTH by Subtle Medical is an AI-powered software that generates synthetic STIR MRI images from existing T1 and T2 weighted contrasts with zero acquisition time, improving efficiency and patient experience in medical imaging.
AiMIFY (1.x)
Subtle Medical
Neurology AI
AiMIFY (1.x) by Subtle Medical is an AI-powered software that enhances brain MRI scans by amplifying contrast to improve the visualization of small and poorly enhanced lesions, sold by Bracco.
SubtlePET
Subtle Medical
Oncology AI
SubtlePET is an AI-powered image processing software that enhances PET image quality from faster, lower-dose scans, improving patient experience and workflow efficiency.
SubtleMR
Subtle Medical
Radiology & Imaging AI
SubtleMR by Subtle Medical is an AI-powered software that enhances MRI image quality through denoising and sharpness improvement, enabling up to 60% faster scan times and seamless integration into existing radiology workflows.

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Press & Coverage

PR Newswire
Subtle Medical Secures $33 Million in Growth Capital Led by Morgan Stanley Expansion Capital and Appoints Industry Veteran Ohad Arazi as CEO
Subtle Medical announced securing $33 million in Series C funding led by Morgan Stanley Expansion Capital and the appointment of Ohad Arazi as its new CEO. This capital will accelerate product development and global commercial expansion of its AI imaging platform across MRI, PET, and CT workflows.
2026-06
Fierce Biotech
AI-powered medical imaging startup Subtle Medical picks up $33M and taps new CEO
Subtle Medical has raised $33 million in growth capital, bringing its total funding to $86 million, and named Ohad Arazi as CEO. The company plans to use the funds to advance product development and expand its AI imaging platform globally for MRI, PET, and CT.
2026-06
PR Newswire
Subtle Medical Receives FDA Clearance for SubtleHDu2122(CT), Expanding AI-Powered Image Enhancement into CT Imaging
Subtle Medical announced FDA clearance for SubtleHDu2122(CT), an AI-powered image enhancement solution for CT imaging, designed to reduce noise and improve low contrast detectability. This marks the company's first CT product and its 11th FDA-cleared product overall.
2026-06
PR Newswire
Subtle Medical Receives FDA Clearance for SubtleHDu2122(PET), Next-Generation AI-Powered Image Acceleration and Enhancement Software
Subtle Medical received FDA clearance for SubtleHDu2122(PET), its next-generation AI-powered PET image enhancement solution, which improves image quality and accelerates PET imaging workflows across PET/CT and PET/MR systems. The software supports all FDA-approved radiotracers and can enable up to 75% faster PET imaging.
2026-05
Subtle Medical
Subtle Medical to Showcase AI Innovations at NVIDIA GTC 2026
Subtle Medical announced its participation in NVIDIA GTC 2026, where it will present technical posters on how SubtleHDu2122-enhanced data improves downstream accuracy and a foundation model for MRI data standardization. The company has a long-standing partnership with NVIDIA, collaborating to accelerate AI development in medical imaging.
2026-03
PR Newswire
Subtle Medical Advances the Future of AI-Powered Imaging at ECR 2026
Subtle Medical participated in the European Congress of Radiology (ECR) 2026, presenting fourteen presentations on advances in AI-driven image enhancement, synthesis, and standardization across MRI and PET imaging, with early research supporting expansion into CT.
2026-03
Subtle Medical
Subtle Medical's SubtleHD(MR)u2122 Wins FDA Clearance, Setting a New Benchmark for MRI Image Quality and Speed
Subtle Medical announced FDA clearance for SubtleHDu2122(MR), an advanced MRI acceleration and enhancement software. This approval launched Subtle-ELITEu2122, a suite of three AI-powered tools designed to improve image quality and reduce MRI scan times by up to 80%.
2025-02
Subtle Medical
Subtle Medical Announces Positive Findings from Proof-of-Concept Study with Bayer Investigating AI To Lower Gadolinium Dose in CE-MRI
Subtle Medical announced positive findings from a proof-of-concept study with Bayer, evaluating SubtleGADu2122 technology for lowering gadolinium dose in contrast-enhanced MRI. The study suggested that AI-synthesized reduced-dose images were similar to standard full-dose images in lesion visualization.
2025-10

Frequently Asked Questions

Subtle Medical offers a suite of AI-powered solutions, including the Subtle-ELITEu2122 package for MRI, which comprises SubtleHDu2122 for image enhancement and acceleration, SubtleSYNTHu2122 for synthetic image generation, and SubtleALIGNu2122 for automated brain MR alignment. They also provide SubtlePETu2122 for faster, lower-dose PET imaging, and SubtleMRu2122 for enhanced and accelerated MRI scans. While primarily focused on MRI and PET, Subtle Medical is also conducting early research into expanding its AI solutions to CT imaging.
Subtle Medical's AI solutions significantly improve image quality through denoising and sharpening, enabling faster scan times (up to 80% for MRI and 75% for PET) without compromising diagnostic confidence. This leads to a better patient experience by reducing discomfort and anxiety associated with long scan durations, and potentially fewer rescans. Additionally, investigational technologies like SubtleGADu2122 aim to dramatically reduce gadolinium contrast agent dosage while maintaining image quality, benefiting sensitive patient populations.
Integrating Subtle Medical's vendor-neutral software seamlessly into existing radiology workflows allows for increased patient throughput and optimized scanner utilization, extending the lifespan of current equipment without costly hardware upgrades. The solutions enable faster acquisition protocols, which translates to more patients scanned per day and reduced wait times for critical imaging procedures. Furthermore, upcoming workflow features like SubtleALLYu2122 aim to standardize processes, reduce manual tasks, and provide performance insights to alleviate radiologist burnout.
Yes, Subtle Medical's core products like SubtleMRu2122, SubtlePETu2122, SubtleSYNTHu2122, SubtleHDu2122, and SubtleALIGNu2122 have received FDA clearance and CE Mark approval, allowing their use in the US and European Economic Area. Their AI solutions are designed to be vendor-neutral, integrating seamlessly with any brand, make, or model of existing MRI and PET scanners and PACS systems.
Subtle Medical is a recognized leader in AI-powered medical imaging, having been named a CB Insights GenAI 50 company and a two-time CB Insights Top AI 100 and Digital Health 150 company. Their solutions are deployed on over 1000 scanners worldwide across more than 16 countries, demonstrating significant global adoption and growth. They have established strategic partnerships with key industry players like Bracco, Bayer, Strategic Radiology, and 626, which further expand their reach and capabilities.
Subtle Medical is actively developing solutions to address contrast agent concerns, notably with its investigational SubtleGADu2122 software, which aims to enable up to a 90% reduction in gadolinium-based contrast agent (GBCA) dosage while maintaining diagnostic image quality. This technology has the potential to benefit millions of patients, including pediatric, neonatal, and those with chronic kidney disease or concerns about gadolinium retention. Additionally, their partnered solution AiMIFYu2122 (sold by Bracco) enhances brain lesion visualization using standard approved Gd doses.

Investors

Who's funded Subtle Medical.

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