OSF Ventures is the corporate venture capital arm of OSF HealthCare, investing financially, operationally, and strategically in post-seed healthcare companies. They target medical devices, diagnostics, health IT, therapeutics, and tech-enabled delivery solutions that can improve patient outcomes, enhance patient experience, and reduce the cost of care.
About OSF HealthCare Ventures
OSF HealthCare Ventures is the corporate investment arm of OSF HealthCare, a multi-state Catholic non-profit health system based in the US Midwest. Strategic-CVC is the dominant lens here: OSF Ventures invests primarily to advance OSF’s clinical and operational priorities, meaning portfolio companies are typically expected to provide meaningful pilot, deployment or strategic value back to the health system. The fund focuses on digital health, clinical workflow, patient experience, virtual care, AI-enabled clinical tools, and adjacent enterprise software, with selective exposure to medical devices and diagnostics. Check sizes are typically in the $500K to $5M range as a participant in seed through Series B rounds, occasionally larger, alongside financial VC leads. For healthcare founders, OSF Ventures is highly relevant if your product has a credible deployment fit within an integrated delivery network and if you can absorb a structured pilot relationship as part of the investment. The unlock for founders is real customer access, clinical champions and the ability to point at OSF as a reference site. Founders building consumer-direct, life-sciences therapeutics, or anything outside the integrated-delivery use case will find weaker alignment. Entry is best via warm introductions from financial co-investors, OSF clinical leaders, or regional healthcare ecosystem connectors; cold outbound via the website’s contact form is workable. Founders should be prepared for parallel investment and commercial diligence and should clarify pilot expectations, exclusivity, and decision timelines before deep engagement.
Founder reviews
Healthcare AI tools backed by OSF HealthCare Ventures
Tools made by companies in OSF HealthCare Ventures's portfolio that we cover in the directory.
Portfolio companies in our directory
Other portfolio companies
Companies in OSF HealthCare Ventures's portfolio not currently in our directory.
Team
Pitch / review this investor
Have you raised from OSF HealthCare Ventures? Founders only — share your honest experience (anonymous OK, moderated before publishing).