cNeuro cMRI

by Combinostics Oy  · Based in Finland → — A complete AI solution to support the early detection, diagnosis, and management of major neurological disorders.
Neurology Radiology

Contact vendor
Regulatory Status Disclosed

Overview

cNeuro cMRI is a cloud-based AI software that provides fully automated brain MRI quantification, designed to increase throughput, enhance objectivity, and deliver high-quality reporting for improved patient care. It integrates with PACS, allowing results to be viewed within PACS or through the cNeuro browser-based viewer. The software objectively quantifies disease-specific abnormalities and patterns, reducing variability in radiological interpretation. It performs reliable and reproducible analysis of brain T1 and FLAIR MRI, including volumes of 133 cortical and subcortical regions, white-matter lesions, and additional disease-specific biomarkers. cNeuro cMRI also quantifies longitudinal changes in brain structure and lesions, aiding in the identification of subtle, disease-specific changes difficult to detect visually. The tool automates the reporting of objective, clinically meaningful data, saving time for radiologists and improving collaboration with referring clinicians through clinically focused reports for conditions like dementia, multiple sclerosis (MS), traumatic brain injury (TBI), and epilepsy. The software compares calculated volumes to a normative database of over 10,000 healthy controls, highlighting deviations from normal.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Fully automated brain MRI quantification
  • Increased throughput and objectivity
  • High-quality, clinically focused reports
  • Integration with PACS
  • Browser-based viewer for results
  • Quantification of 133/135 cortical and subcortical regions (T1)
  • White-matter lesion quantification (FLAIR)
  • Quantification of longitudinal changes in brain structure and lesions
  • Disease-specific biomarkers (e.g., MTA, GCA, Fazekas scales)
  • Comparison to normative database

Use Cases

  • Early detection and differential diagnostics in Alzheimer's disease and other dementias
  • Diagnosis and management of Multiple Sclerosis (MS)
  • Diagnosis and management of Traumatic Brain Injury (TBI)
  • Diagnosis and management of Epilepsy
  • Objective assessment of atrophy and lesion load
  • Longitudinal monitoring of subtle brain changes

What Physicians Need to Know

Brain MRI Analysis
cNeuro cMRI provides fully automated, reliable, and reproducible quantification of brain MRI scans. It analyzes T1 and FLAIR MRI images to provide volumes of 133 cortical and subcortical regions, white matter lesions, and other disease-specific biomarkers. It also quantifies longitudinal changes in brain structure and lesions. The software compares results to normative reference data adjusted for age, sex, and intracranial volume. It supports cross-sectional and longitudinal analysis.
Neurodegenerative Disease Screening
cNeuro cMRI is part of the cNeuro platform, which offers tools to support clinicians in the early detection, differentiation of diagnosis, treatment, and ongoing management of patients with neurodegenerative disorders. This includes conditions such as Alzheimer's disease, dementia, multiple sclerosis, traumatic brain injuries, and epilepsy.
Reporting and Throughput
The tool aims to increase throughput by reducing the time spent per image read while maintaining quality. It automates the reporting of objective, clinically meaningful data. Clinically focused reports for dementia, multiple sclerosis, traumatic brain injuries, and epilepsy facilitate patient management and communication between radiologists, neurologists, patients, and caregivers.
Physician Tip

cNeuro cMRI provides objective, quantitative data from brain MRI scans, which can help in identifying subtle, disease-specific changes that might be difficult to detect through visual assessment alone. The automated analysis and comparison to normative data can aid in differential diagnosis and tracking disease progression in neurodegenerative disorders. The clinically focused reports can improve communication with referring clinicians and patients.

cNeuro cMRI is a cloud-based AI software that integrates with PACS. Results can be viewed directly in PACS or through the cNeuro browser-based viewer. It can also be used as a standalone application. The cNeuro platform connects cMRI with cDSI (Clinical Decision Support Intelligence) and other external data sources to provide comprehensive patient management by combining imaging data with other patient information like clinical tests, neuropsychological tests, and demographic data.

Details

Category Neurology AI, Radiology & Imaging AI
Pricing Contact vendor
DeploymentCloud-based
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status Cleared AI-estimated
Integrations
EHR Not specified
Specialties Neurology, Radiology

What the Web Says

cNeuro cMRI is an AI-powered software that quantifies brain structures from MRI scans, aiding in the diagnosis and management of neurodegenerative disorders like Alzheimer's, MS, and dementia. It integrates with PACS and offers cloud-based viewing, providing objective measurements and reports for radiologists and referring physicians. The software aims to increase accuracy, reduce reading time, and improve collaboration in patient care.

Overall: Mixed

Strengths

  • Provides automated and objective quantification of brain structures from MRI scans.
  • Supports early diagnosis and management of neurodegenerative disorders such as Alzheimer's, MS, and dementia.
  • Integrates with PACS and offers a browser-based viewer for results.
  • Reduces the time spent per image read, increasing throughput.
  • Offers high-quality, clinically focused reports that improve communication between radiologists and referring clinicians.
  • Backed by over 50 peer-reviewed publications and collaborations with academic institutions.

Limitations

  • Not FDA cleared for ARIA monitoring in the US, which may be a significant drawback for clinics with anti-amyloid infusion programs.
  • US sales have developed weaker than expected and fell in the first half of 2026.
  • Switching from cNeuro may be considered due to issues like an ARIA gap, support problems, or platform changes.
  • Some Reddit discussions indicate general frustrations with MRI results not always correlating with severe neurological symptoms, though this is not specific to cNeuro cMRI.

Based on reviews from: siemens-healthineers.com, xrayinterpreter.com, combinostics.com, indeed.com, radiological.ai, youtube.com, scispace.com, springermedizin.de, surgi-plan.com, vttresearch.com, sectra.com, theimagingwire.com, nih.gov, reddit.com, capterra.com, unirioja.es, clinicaltrials.gov, huggingface.co, biorxiv.org, hemeoncbuddy.org, capterra.com.au, expertini.com

Last updated: 2026-10-29

Ratings & Reviews

No reviews yet. Be the first to review this tool!

Rate cNeuro cMRI

Clinical Value
Ease of Use
Integration
Support & Docs
Value for Money

Press & Coverage

Health AI Register
Brain Age MRI Tool Improves Dementia Risk Stratification in Early Cognitive Decline
A recent study published in Neurology in 2026 indicates that brain-predicted age difference (brain-PAD), calculated by Combinostics' cNeuro cMRI platform, can significantly improve dementia risk stratification, especially in patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI). The AI-generated brain age metrics from routine structural MRI scans enhance early intervention planning and resource allocation in memory clinics.
2026-10
TeraRecon
TeraRecon Enhances Eureka Clinical AI Platform with Combinostics' cMRI for Comprehensive Neuroradiology Solutions
TeraRecon has integrated Combinostics' cNeuro cMRI into its Eureka Clinical AI platform, providing clinicians with advanced AI and deep learning technology for neuroradiology. This collaboration aims to offer comprehensive solutions for assessing patients with neurodegenerative diseases by providing accurate and consistent quantitative evaluations of MRI brain scans.
2023-04
Combinostics
Combinostics' cDSI and cMRI Applications, Part of the cNeuro Platform, Receive EC-certification Under the EU's Medical Device Regulation (MDR)
Combinostics announced that its cDSI and cMRI applications, part of the cNeuro platform, have received EC-certification under the European Union's Medical Device Regulation (MDR). This certification ensures the continued delivery of these services to customers in the EU, UK, and Switzerland, supporting clinicians in the early detection, diagnosis, and management of neurodegenerative disorders.
2022-06
Combinostics
Combinostics Releases cNeuro 2.1.0 with New Dementia Differential Analysis Report and Enhanced MRI Quantifications
Combinostics launched version 2.1.0 of its cNeuro platform, which includes the cDSI and cMRI applications, featuring a new Dementia Differential Analysis report and additional automated MRI quantifications. This update provides new biomarkers, quantification of FLAIR lesion counts, and T1 hypointensity volumes to aid in the diagnosis and management of neurodegenerative diseases.
2022-06
Combinostics
Combinostics receives FDA clearance for cNeuro cMRI
Combinostics received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its image quantification software cNeuro cMRI. This software provides objective measurements of atrophy in brain regions and white matter hyperintensities, which are valuable for diagnosing dementia and other neurodegenerative diseases.
2018-01
Combinostics
Combinostics and Siemens Healthineers partner to distribute cNeuro cMRI application
Combinostics and Siemens Healthineers announced a partnership to distribute Combinostics' cNeuro cMRI application through the Siemens Healthineers Digital Ecosystem. This collaboration aims to integrate cNeuro cMRI into healthcare IT systems, allowing seamless image uploads, result viewing, and report saving for clinicians.
2018-03

Videos

Product demos, reviews, and walkthroughs for cNeuro cMRI.

View all on YouTube

Frequently Asked Questions

cNeuro cMRI is a cloud-based AI software that integrates with PACS, allowing results to be viewed directly within your existing PACS or through the cNeuro browser-based viewer. It takes T1 and FLAIR MRI images as input and provides automated quantification of brain structures and lesions, generating PDF reports that can be sent back to PACS.
cNeuro cMRI is CE marked and FDA 510(k) cleared, indicating it meets the necessary regulatory standards for medical devices in Europe and the United States. All data transfers utilize SSL encryption, and stored data are anonymized and encrypted to ensure security and privacy.
While cNeuro cMRI offers automated quantification of brain MRI, it is intended to automate the manual process of identifying, labeling, and quantifying segmentable brain structures. It is a tool to support medical professionals working with medical imaging, and the results should be interpreted in conjunction with clinical expertise.
Several FDA-cleared alternatives exist for brain MRI quantification, including Cortechs.ai NeuroQuant, icometrix icobrain (now GE HealthCare), DeepHealth Brain (formerly Quantib), Neurophet AQUA, and Neuroreader. These tools also provide automated measurements of brain volumes and lesions against normative databases.
Combinostics does not publicly list pricing for cNeuro cMRI; however, they offer a free trial for healthcare providers within regulatory-cleared regions, accommodating a maximum of 10 cases for evaluation purposes. You can request a demo or trial through their website.
cNeuro cMRI can support the detection and monitoring of various neurological conditions, including dementias (such as Alzheimer's disease, frontotemporal dementia, and vascular dementia), multiple sclerosis, Parkinson's disease, traumatic brain injury, and epilepsy. It quantifies atrophy and lesion load, comparing results to reference data and normative databases.

Related Tools

Parkiwatch
Koios Care
Neurology AI
Parkiwatch by Koios Care is a Class IIa Software as a Medical Device (EU MDR 2017/745) for continuous, passive detection and quantitative assessment of kinematic patterns representative of tremor, bradykinesia, and dyskinesia in adults with Parkinson's Disease.
CortiCare (Virtual EEG Department)
CortiCare
Neurology AI
CortiCare offers 24/7 remote EEG monitoring and interpretation services, functioning as a virtual EEG department to assist hospitals and neurology practices in identifying seizures and other neurological conditions.
NeuroAstra
Avinya NeuroTech
Clinical Decision Support & Reference
NeuroAstra is an AI-enabled EEG analysis and reporting software that provides a multimodal clinical EEG web platform with Co-Pilot AI to help neuro care teams detect abnormal trends faster and standardize reporting.
Cercare Medical Oncology Virtual Expert
Cercare Medical
Neurology AI
Cercare Medical's Oncology Virtual Expert is an AI-powered brain tumor segmentation module that provides fast, consistent, and semi-automated tumor analysis from standard MRI data, designed for on-premise deployment within existing clinical radiology workflows.
CoLumbo C-Spine
Smart Soft Healthcare AD
Clinical Decision Support & Reference
CoLumbo C-Spine is an AI-powered software that processes and analyzes cervical spine MRI exams, assisting clinicians in diagnosis and assessment.
MeRT System
Wave Neuroscience
Mental & Behavioral Health AI
MeRT (Magnetic e-Resonance Therapy) is an advanced, personalized form of TMS that uses your own brainwave data to guide treatment. It's a non-invasive, drug-free option designed to help the brain communicate more efficiently so symptoms of conditions like depression, anxiety, PTSD, TBI, autism, and more can improve.

See all Neurology AI tools →

Suggest an Edit → | Report an issue | Last Verified: 2026-04-18 | First Added: 2026-04-18
AI Tool Finder
AI-powered search. Results may not be comprehensive.