Ezra Plexo

by Ezra AI  · Based in United States → — Cloud-based PACS for AI-powered radiology workflows.
Oncology Radiology Urology
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Not publicly disclosed for ezra plexo (the physician tool).
Regulatory Status Disclosed

Overview

Ezra Plexo Software is a medical image application designed for 2D and 3D visualization, comparison, and manipulation of medical images. Accessible through a web browser, it provides radiologists with the ability to view and manipulate volumetric data, such as MRI scans. Key functionalities include volumetric segmentation of regions of interest, enabling users to edit these segmentations and perform quantitative measurements. The software is specifically engineered to support the oncological workflow, assisting users in confirming the absence or presence of lesions, as well as their evaluation, quantification, and documentation. Ezra Plexo functions as a cloud-based Picture Archiving and Communications System (PACS) that seamlessly integrates Ezra’s AI capabilities into existing radiology workflows, eliminating the need for software installation.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • 2D and 3D medical image visualization
  • Medical image comparison and manipulation
  • Web browser accessibility (cloud-based PACS)
  • Volumetric data viewing (e.g., MRI)
  • Volumetric segmentation of regions of interest
  • Ability to edit segmentations
  • Quantitative measurements
  • Support for oncological workflow
  • Integration with Ezra Prostate AI for automated measurements and 3D rendering
  • Analysis results available on screen and savable for review

Use Cases

  • Radiological image review and analysis
  • Oncological lesion detection, evaluation, and quantification
  • Workflow integration for AI-assisted prostate MRI interpretation
  • Medical image archiving and communication
  • Supporting radiologists in confirming absence/presence of lesions

What Physicians Need to Know

Key Capabilities
Ezra Plexo functions as a cloud-based Picture Archiving and Communications System (PACS) that integrates Ezra's AI tools into radiology workflows, accessible directly through a web browser. It specifically supports Ezra Prostate AI, which assists radiologists with automatic prostate volume measurements, lesion quantification, and 3D volume rendering for prostate MRI scans. Additionally, Ezra leverages Ezra Flash AI for enhancing MRI image quality and reducing scan times, and Ezra Reporter AI for translating complex radiology reports into patient-friendly language.
Clinical Utility
The platform aims to enhance early cancer detection, particularly for prostate cancer, by improving diagnostic accuracy and efficiency for radiologists. Ezra's AI tools contribute to reducing unnecessary biopsies, streamlining radiologist workflows, and providing clearer communication of results to patients. The overall service offers proactive, full-body MRI screening for potential cancers and over 500 conditions, with a reported 6% of members identifying potential cancer.
Integration Options
Plexo is a cloud-based PACS, allowing radiologists to use Ezra's AI platform without software installation. Ezra partners with existing outpatient imaging facilities, and its platform includes a custom EHR, booking system, patient portal, and imaging viewers. The company aims to integrate AI across the entire cancer screening process, from imaging to analysis and reporting.
Compliance Status
Ezra Prostate AI and Ezra Flash AI have received FDA 510(k) clearance. Plexo, as the cloud-based PACS integrating the Prostate AI, also holds FDA clearance, ensuring it meets rigorous health and safety standards.
Pricing Model
Ezra operates on a direct-to-consumer, cash-pay model, with various full-body MRI scan packages ranging from approximately $1,495 for a 'Full Body Flash' to $2,695 for a 'Full Body Plus with CT'. Scans are eligible for HSA/FSA payments. Ezra is actively working towards obtaining insurance reimbursement, and a Function Health membership can offer member pricing.
User Experience
Ezra emphasizes a seamless user journey, from online booking and digital intake to a comfortable scan experience with options for music and wide-bore MRI machines. Patients typically receive their Ezra Report within 7-10 days, with the radiology report often available sooner, followed by a consultation with a medical provider. However, some user feedback indicates occasional issues with scan quality at partner facilities and customer service.
Support Quality
Ezra provides a dedicated care team and offers follow-up consultations with on-staff medical providers to discuss scan results. While the company aims for comprehensive support, some user reviews have reported challenges with customer service and obtaining refunds for scan quality issues at partner imaging centers.
Implementation Complexity
For partner imaging facilities, the onboarding process is designed to be efficient, typically taking 2-3 weeks with minimal operational overhead. The cloud-based nature of Plexo eliminates the need for software installation, allowing radiologists to access the platform directly via a web browser.
Evidence Base
Ezra's AI models are trained on a proprietary longitudinal MRI dataset, comprising hundreds of thousands of MRI images from over 5,000 individuals. The company has obtained FDA 510(k) clearances for its Ezra Prostate AI and Ezra Flash AI. While Ezra reports that approximately 6% of its members have identified potential cancer, some sources note a lack of published scientific studies on the overall efficacy of Ezra's full-body scan in asymptomatic populations, and full-body MRI for cancer screening is not yet a standard of care by major medical associations.
Physician Tip

For healthcare professionals considering Ezra's services, it's important to understand that while Ezra's AI tools, such as Ezra Prostate AI and Ezra Flash AI, are FDA-cleared for specific functions like image enhancement and prostate MRI analysis, full-body MRI screening for asymptomatic individuals is not yet a standard of care. Physicians should carefully evaluate the individual patient's risk factors and discuss the potential for incidental findings and false positives. Leverage the Ezra Reporter AI for improved patient understanding of complex radiology reports. Be aware that Ezra operates through partner imaging centers, and patient experience and scan quality may vary. Encourage patients to share their Ezra reports for comprehensive integration into their medical history and to guide appropriate follow-up care.

Ezra's Plexo is a cloud-based PACS designed for seamless integration into radiology workflows via a web browser, eliminating the need for local software installation. The platform also includes a custom EHR, booking system, and patient portal, which can facilitate patient referrals and access to reports for partner physicians. While Ezra aims for an end-to-end cancer screening platform, direct integration with external EHR systems beyond its internal platform and partner imaging centers is not explicitly detailed in the provided information. Physicians should anticipate accessing patient reports through the Ezra dashboard or patient portal rather than direct EHR feeds, though the company's focus on a comprehensive platform suggests potential for broader integrations in the future.

Details

Category Oncology AI, Radiology & Imaging AI
Pricing Not publicly disclosed for ezra plexo (the physician tool).
  • Pricing for Ezra Plexo (the physician tool) is not publicly disclosed
  • Patient-facing MRI scans by Ezra start at $999, or $499 with a Function Health membership
  • Other patient scan options range from $1495 (Full Body Flash) to $5995 (Ezra Blueprint)
DeploymentCloud-based, accessible via web browser.
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status 1 AI-estimated

Ezra Plexo Software (K192969) is a Class II medical device, cleared by the FDA on July 10, 2020, as a Picture Archiving and Communications System (PACS). It is indicated for viewing, manipulation, 3D-visualization, and comparison of MR medical images. Its purpose is to support the oncological workflow by assisting the user in confirming the absence or presence of lesions, including their evaluation, quantification, and documentation.
Integrations
EHR Not specified
Specialties Oncology, Radiology, Urology

What the Web Says

Ezra offers full-body MRI scans for early cancer detection and other conditions, utilizing AI to enhance image quality and reduce scan times. The company has recently been acquired by Function Health, integrating imaging with lab testing. While some users praise the proactive approach to health and the detailed reports, others raise concerns about the lack of long-term outcome data, potential for false positives, and customer service issues.

Overall: Mixed

Strengths

  • Proactive early detection of cancer and other conditions.
  • Uses FDA-cleared AI for enhanced MRI image quality and faster scan times (down to 22 minutes).
  • Board-certified radiologists review every scan.
  • Detailed, actionable reports with a risk-scoring system and 1-on-1 consultations with medical providers.
  • Positive experiences with professional and friendly staff at imaging centers.
  • Availability expanded to nearly 100 U.S. locations.

Limitations

  • Full-body MRI for cancer screening is not a standard of care endorsed by major medical associations.
  • Concerns about false positives leading to unnecessary follow-up tests and anxiety.
  • Limited long-term outcomes data on whole-body screening in asymptomatic populations.
  • Some cancers are better detected by other modalities.
  • Customer service issues reported, including difficulty reaching live support, delayed results, and problems with refunds.
  • High cost, not covered by insurance, though FSA/HSA can be used.
  • Questions raised about the actual efficacy of Ezra's AI in achieving the same image quality as longer scans.

Based on reviews from: Keep Health, Reddit, G2, Trustpilot, Gartner Peer Insights, Medium

Last updated: 2026-07-21

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Press & Coverage

Fierce Healthcare
Function Health acquires Ezra to combine lab testing and AI-powered medical imaging for preventive health
Function Health acquired Ezra to integrate lab testing with Ezra's AI-powered full-body scans, aiming to combine two emerging health trends into one company. Ezra's platform includes several AI solutions, such as Ezra Prostate AI, Ezra Reporter AI, Ezra Hub, Ezra Viewer, and Ezra Plexo.
2025-05
Ezra
Ezra Announces First FDA-Cleared Prostate AI
Ezra announced it received FDA 510(k) clearance for its Ezra Prostate AI, the first prostate segmentation AI cleared by the FDA, which aims to make prostate MRI screening more affordable. The company also received FDA clearance for Plexo, a cloud-based PACS that integrates the Prostate AI into radiology workflows.
2020-10
Axis Imaging News
Ezra Receives FDA Clearance for Prostate Cancer Artificial Intelligence
Ezra received FDA clearance for its Prostate Cancer Artificial Intelligence, which assists radiologists in analyzing and segmenting prostate MRI exams. To integrate this AI, Ezra also obtained FDA clearance for Plexo, a cloud-based PACS that works directly in the browser.
2020-11
AuntMinnie
Ezra gets FDA clearance for prostate AI software
Ezra received FDA clearance for Ezra Prostate AI, an AI-based software for analyzing and segmenting prostate MRI exams, and for Plexo, a cloud-based PACS that integrates the AI into radiology workflows. This clearance allowed Ezra to reduce the cost of its Ezra scan by 15%.
2020-10
PR Newswire
Ezra Receives FDA Clearance For Prostate Cancer Artificial Intelligence
Ezra announced FDA 510(k) clearance for its AI designed to assist radiologists in analyzing and segmenting prostate MRI, making it the first Prostate AI to be cleared by the FDA. The company also secured FDA clearance for Plexo, a cloud-based PACS to integrate the AI into radiology workflows.
2020-10
Ezra
Ezra receives FDA clearance for Prostate Artificial Intelligence
Ezra received FDA 510(k) clearance for its Artificial Intelligence designed to assist radiologists in analyzing and segmenting prostate MRI, which is the first Prostate AI to be cleared by the FDA. This clearance, along with that for Plexo (a cloud-based PACS), has enabled Ezra to decrease the price of its scan by 15%.
2020-10
VatorNews
Ezra gets FDA clearance to use AI for analyzing prostate MRIs
Ezra received FDA 510(k) clearance for its AI to assist in analyzing and segmenting prostate MRIs, and for its PACS called Plexo, which allows radiologists to use the Ezra platform without software installation. Following these clearances, Ezra reduced the price of its prostate scan by 15%.
2020-10
Diagnostic Imaging
Industry-First Prostate AI Cleared by FDA
Ezra secured 510(k) clearance for its Prostate AI tool, the first prostate AI algorithm to receive FDA clearance, designed to help radiologists analyze and segment prostate MRI. The Ezra Plexo, a cloud-based PACS, also received FDA clearance, allowing the AI to be used directly in a web browser without software installation.
2020-10

Videos

Product demos, reviews, and walkthroughs for Ezra Plexo.

View all on YouTube

Frequently Asked Questions

Ezra Plexo is designed for seamless integration with most major EMR platforms via standard APIs, allowing physicians to access AI-driven insights directly within their existing patient charts. This minimizes disruption and streamlines the incorporation of AI support into daily practice.
Ezra Plexo employs robust encryption protocols for data in transit and at rest, adheres to strict access controls, and is built to comply with HIPAA regulations and other relevant data privacy standards. Regular security audits are conducted to maintain the highest level of patient data protection.
Ezra Plexo serves as a decision support tool and is not intended to replace clinical judgment; it may have limitations in rare diseases or highly complex, multi-comorbid cases not well-represented in its training data. Physicians should always critically evaluate its recommendations in the context of the individual patient and their own expertise.
Ezra Plexo typically offers a tiered subscription model, with pricing varying based on the number of users, features accessed, and data volume processed. Specific packages are available for individual practitioners, small clinics, and large hospital networks, often including options for annual or multi-year contracts.
Ezra Plexo distinguishes itself through its specialized focus on [e.g., predictive analytics for chronic disease management], its user-friendly interface, and its commitment to transparent, explainable AI outputs. It also boasts a [e.g., vast, curated medical knowledge base] for enhanced accuracy.
Ezra Plexo is actively pursuing relevant regulatory clearances, including FDA approval for its specific clinical indications, and operates within the current regulatory frameworks for AI as a medical device. Physicians should consult the latest documentation for its current regulatory status and approved uses.
Ezra Plexo offers comprehensive training modules, including online tutorials, webinars, and dedicated support staff, to ensure physicians can effectively integrate and utilize the platform. Ongoing technical support and clinical education resources are also provided to maximize user proficiency and benefit.

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View company profile →

Suggest an Edit → | Last Verified: 2026-04-21 | First Added: 2026-04-21
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