Medisafe
Freemium
Overview
Medisafe is a digital health platform designed to facilitate patient engagement, primarily for pharmaceutical companies. It aims to support patients in managing their medications and navigating treatment plans. The platform is utilized across various therapeutic areas, including cardiovascular, immunology, mental health, metabolic/GLP-1, neurology, and oncology, particularly for complex and specialty therapies where sustained patient engagement is considered critical.
- What it does: Medisafe provides digital tools to help patients with medication management and treatment plan adherence. For pharmaceutical companies, it extends patient support programs digitally to engage patients and aims to improve adherence and time on therapy.
- Who it is for: The platform is primarily for pharmaceutical companies to support their patient populations. It also offers tools for providers to reinforce treatment plans between visits and for patients to manage their own medication schedules.
- How it fits a clinical or practice workflow: In a clinical or practice workflow, Medisafe can serve as a digital adjunct to reinforce treatment plans and medication use between patient visits. It offers a mechanism for providers to extend support beyond the point of care through digital tools.
- Notable capabilities: Medisafe focuses on behavior-driven digital engagement. It is designed to activate patients earlier in their treatment journey and maintain engagement over time.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- Personalized medication reminders
- Medication tracking and adherence reporting
- Drug interaction warnings
- 90+ health measurement trackers
- Caregiver/family support (Medfriend)
- Refill and appointment reminders
- Complex dosage scheduling
- Digital drug companion programs (Enterprise)
- Predictive AI for non-adherence risk
- Omnichannel patient engagement
Use Cases
- Medication adherence improvement
- Chronic disease management
- Caregiver support and coordination
- Pharma patient support programs
- Clinical trial support
- Post-transplant medication management
What Physicians Need to Know
Patient Portal Integration
Medisafe offers a web-based reporting portal for patients to view their daily calendar and generate reports, which can be shared with their doctor. For iPhone users, Medisafe integrates with Health Records on iPhone, allowing automatic import of medications. Medisafe's Care Widgets also enable integration with existing patient support systems, allowing care coordinators to enroll patients in digital drug companion programs and share instructional videos.
Appointment Scheduling AI
Medisafe provides appointment reminders as part of its comprehensive features. The enterprise-level Care Connector platform also includes appointment management capabilities.
Multi-Language Patient Support
Medisafe offers multilingual interfaces and localization features, extending AI-driven personalization across languages. The Medisafe app itself can be switched to different language modes. Its AI voice agent, VIA, is also multilingual.
Health Literacy Adaptation
Medisafe aims to improve health literacy by providing medication educational content, including medication cards and videos. The app's user-friendly design and simple language contribute to its accessibility. Studies have shown high patient satisfaction and ease of use, even among medically underserved populations.
Chronic Disease Management
Medisafe significantly improves medication adherence for patients with chronic conditions like hypertension, diabetes, and heart disease. It offers tools to track over 90 measurements, including blood pressure, glucose, and cholesterol, with integration for Apple Health. The 'Pathways' web-based tool is specifically designed for managing FDA-approved treatments for chronic diseases, allowing HCPs to track patient visits, infusions, and treatment adherence.
Medication Adherence Features
Medisafe is a leading medication adherence platform, providing personalized, customizable reminders that require user confirmation. It offers complex dosage scheduling, drug interaction warnings, and refill reminders. The 'Medfriend' feature allows a designated friend or family member to be notified if a dose is missed, providing an additional layer of support. Medisafe's proprietary Just-In-Time Intervention (JITIu2122) AI predicts nonadherence risk and delivers targeted, personalized interventions.
Patient Education Content
The app provides medication educational content in the form of medication cards and videos. It also offers therapy-specific education and side-effect management. This content is tailored to each therapy and condition.
Accessibility Compliance
Medisafe is HIPAA and GDPR compliant, and ISO 27001:2013 and ISO 13485:2016/2022 certified, ensuring high levels of data security and quality management for medical devices. The app is designed to be user-friendly and intuitive, adapting to different screen sizes.
Physician Tip
Encourage patients, especially those with chronic conditions or complex medication regimens, to utilize Medisafe for improved adherence and self-management. Leverage the web-based reporting portal and Care Widgets to gain insights into patient adherence and engagement between visits, facilitating more informed conversations. Recommend the 'Medfriend' feature for patients who may benefit from additional social support. Utilize Medisafe's educational content to reinforce treatment plans and address patient questions regarding their medications and conditions. Consider integrating Medisafe's enterprise solutions for comprehensive patient engagement programs.
Medisafe offers robust integration capabilities through its Care Connector platform and SDK for enterprise clients (pharmaceutical companies, providers, and payers). It integrates with existing patient support systems, EHRs, CRM systems, and pharma's digital infrastructures. For individual users, it integrates with Apple Health and Health Records on iPhone. The VIA AI voice agent integrates across voice, SMS, app, and web, and can plug into brand hubs and CRM systems.
Details
| Category | Patient Engagement & Education |
| Pricing | Freemium |
| Deployment | SaaS, Cloud |
| Compliance | |
| BAA Available | Yes AI-estimated |
| HIPAA Compliant | Yes AI-estimated |
| FDA Status | Unknown |
| Integrations | |
| EHR | Not specified |
| Specialties | Family Medicine, Hospital Medicine, Internal Medicine |
What the Web Says
Medisafe is a highly-rated medication management app praised by physicians and users for its effectiveness in improving medication adherence. It offers features like customizable reminders, drug interaction alerts, and caregiver support. While generally well-received, recent changes to a subscription model have caused frustration among some long-time users.
Overall: MixedStrengths
- Effective medication reminders that are hard to miss and can be snoozed.
- User-friendly interface and easy setup.
- Drug interaction alerts.
- Ability to track various measurements (blood pressure, glucose, pain).
- Medfriend feature allows caregivers to monitor adherence.
- Supports complex dosing schedules.
Limitations
- Recent shift to a subscription model, limiting free users to only two medications, has caused significant dissatisfaction.
- Delays in Medfriend notifications have been reported.
- Limited integration with electronic medical records and pharmacies for direct data import/export.
- Some users find the app's reporting functionality not easy to navigate.
- Lack of web access to information; management is solely through the smartphone app.
- Occasional technical difficulties with alarms or app functionality.
Based on reviews from: iMedicalApps, Reddit, Tech-enhanced Life, Apple App Store, Medium, Minimalist Journeys, Google Play Store, JMIR Human Factors, G2
Last updated: 2026-09-20
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Press & Coverage
Medisafe
Medisafe Demonstrates Significant Impact on Medication Adherence in Medically Underserved Populations
A new study published in JMIR Human Factors in February 2025 highlights Medisafe's effectiveness in improving medication adherence and health outcomes for chronically ill patients in underserved communities. The research advocates for integrating digital health technologies like Medisafe into clinical practices, especially for populations facing healthcare access barriers.
2025-02
Medisafe
Medisafe Launches VIA: AI Voice Tech That Supercharges Patient Engagement and Slashes Enrollment Friction
Medisafe introduced VIA (Voice Intelligent Agent) in April 2025, an AI voice assistant designed to bridge the patient support gap in pharma by transforming how specialty brands engage and retain patients. VIA integrates across voice, SMS, app, and web, offering proactive, empathetic voice calls to guide patients through onboarding, adherence, and access.
2025-04
Medisafe
Medisafe PATHWAYS, Eisai and Biogen Recognized for Alzheimer's Disease Innovation in 2025 MedTech Breakthrough Awards Program
Medisafe, in collaboration with Eisai and Biogen, received the u201cBest Care Coordination Platformu201d award in May 2025 at the 9th annual MedTech Breakthrough Awards for PATHWAYS. This tool streamlines patient tracking and enhances care coordination for Alzheimer's Disease treatment, particularly for FDA-approved monoclonal antibodies.
2025-05
Medisafe
Revolutionizing Patient Engagement in Pharma: AI Solutions by Medisafe
An October 2025 article discusses how Medisafe's AI-powered platform, anchored in data analytics, behavioral science, and machine learning, is redefining patient engagement for pharmaceutical companies. The Just-in-Time Intervention (JITI) AI predicts non-adherence risk and deploys personalized outreach, leading to documented increases in medication adherence.
2025-10
Medisafe
Novel Randomized Control Trial Reveals Impact of Medisafe on Medication Self-Efficacy and Medication Adherence to Improve Health Outcomes in Medically Underserved Populations
A randomized control trial conducted by Vanderbilt University researchers and published in the Journal of Behavioral Medicine in February 2024 found that Medisafe's app significantly improved medication adherence and self-efficacy in medically underserved populations. The findings suggest a large-scale benefit for implementing the free Medisafe app in Federally Qualified Health Centers.
2024-02
Medisafe
Medisafe Joins Forces with AWS to Leverage GenAI and Build the Future of Connected Health
In October 2023, Medisafe announced its collaboration with Amazon Web Services (AWS) to utilize Medisafe's extensive healthcare data and AWS's AI capabilities to advance connected health. This partnership aims to build the future of connected health through technology advancements and regulatory achievements.
2023-10
Medisafe
Medisafe Expands Business Solutions with New Software as a Medical Device (SaMD)
Medisafe announced in January 2023 the expansion of its business solutions with new Software as a Medical Device (SaMD) technology. This follows their achievement of ISO 13485:2016 certification for medical device quality management systems and ISO 27001:2013 for IT security management.
2023-01
PR Newswire
Medisafe Enhances Pharma Digital Vision with Latest ISO Certification
Medisafe announced in September 2022 that it achieved ISO 13485:2016 certification, which supports the design and development of Software as a Medical Device (SaMD). This certification validates Medisafe's commitment to quality and innovation in advancing connected health for pharma and patients.
2022-09
Videos
Product demos, reviews, and walkthroughs for Medisafe.
Medisafe Introduction
Medisafe
Frequently Asked Questions
Medisafe improves adherence through personalized reminders, educational content, and a supportive community. It tracks medication intake and offers insights into patient behavior, which can be shared with healthcare providers to tailor care plans.
Physicians can access patient adherence reports, missed dose alerts, and other medication-taking behaviors through Medisafe's provider platform, if the patient chooses to share this information. This data can be integrated into electronic health records (EHRs) for a comprehensive view of patient compliance.
While Medisafe is highly effective for many, patients with extremely complex regimens might still require additional support beyond the app. For those with significant cognitive impairments, direct caregiver involvement and supervision may be necessary, as app usage could be challenging.
Medisafe offers a more interactive and data-rich experience than traditional pill organizers, with features like gamification, educational content, and caregiver synchronization. Compared to other apps, it stands out with its robust community support and comprehensive tracking capabilities.
Medisafe offers a free version with core features, and a premium subscription (Medisafe Premium) that unlocks advanced functionalities like unlimited 'medfriends,' more reminder sounds, and detailed progress reports. Pricing for the premium version varies depending on the subscription plan.
Medisafe employs robust security measures, including encryption and adherence to HIPAA compliance standards, to protect patient data. They have a comprehensive privacy policy outlining how data is collected, used, and shared, emphasizing patient control over their information.
Medisafe offers integration capabilities with various digital health platforms and EHR systems, allowing for a more streamlined flow of patient adherence data directly into your practice's existing workflows. This can provide a more holistic view of patient health management.
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| Last Verified: 2026-06-19 | First Added: 2026-06-19
Investors who backed Medisafe
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