SIGNA Premier

by GE Healthcare (GE Medical Systems, LLC)  · Based in United States → — GE Healthcare's most powerful 3T wide-bore MRI scanner, designed for advanced clinical outcomes and research.
Neurology Oncology Radiology
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Regulatory Status Disclosed

Overview

The SIGNA Premier is a high-performance 3.0 Tesla (3T) wide-bore Magnetic Resonance Imaging (MRI) system from GE Healthcare. It is engineered to deliver superior image quality, enhanced patient comfort, and robust clinical capabilities for both routine diagnostic imaging and advanced research. The system features a 70cm wide bore, providing 60cm performance, and incorporates innovative technologies such as SuperG 80/200 Gradients for outstanding stability and performance.

A key advancement in the SIGNA Premier is the integration of artificial intelligence (AI) through its AIR™ Recon DL deep-learning-based reconstruction technique, which significantly improves signal-to-noise ratio (SNR), image sharpness, and enables shorter scan times. Patient experience is prioritized with revolutionary AIR™ Coils, a lightweight and flexible design that conforms comfortably to the patient’s body, and the Comfort Plus patient table. The SIGNA Premier also utilizes the SIGNA™Works productivity platform, offering a suite of applications like HyperBand, HyperSense, and HyperCube for accelerated imaging and streamlined workflows.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • 3.0T wide-bore MRI scanner (70cm bore, 60cm performance)
  • SuperG 80/200 Gradients with 1.2 km All-Hollow wire design
  • AIRu2122 Recon DL deep-learning-based reconstruction for improved SNR and sharpness
  • AIRu2122 Coils for enhanced patient comfort and signal performance
  • 146 independent RF channels for high image quality and faster scanning
  • SIGNAu2122Works productivity platform with advanced pulse sequences and workflow tools
  • HyperBand, HyperSense, and HyperCube acceleration techniques for speed
  • Comfort Plus patient table for improved patient experience and efficiency
  • Advanced diffusion package (PROGRES, SuperG Boost, MUSE) for distortion correction
  • SilentScan Technology for reduced acoustic noise

Use Cases

  • Advanced neurological imaging and research, including Human Connectome Protocol and fMRI
  • Oncology research and clinical diagnosis
  • High-resolution musculoskeletal imaging of bone, joint, and soft tissue
  • Cardiac imaging with up to 12x acceleration
  • Comprehensive body imaging, including free-breathing abdominal scans
  • Academic institutions for scientific endeavors and expanded research capabilities

What Physicians Need to Know

Stroke Detection Speed
SIGNA Premier, utilizing deep-learning reconstruction with AIR Recon DL, significantly reduces MRI scan times by up to 50%, enabling faster image acquisition critical for acute stroke management. This contributes to GE HealthCare's broader commitment to rapid diagnosis in stroke care.
Brain MRI/CT Analysis
SIGNA Premier is an advanced MRI system specifically designed for neurological research and clinical applications. It features deep-learning-based reconstruction (AIR Recon DL) for sharper, clearer, and more accurate images. Automated applications like AIR x use deep-learning algorithms to precisely prescribe MRI slices for neurological exams. The system also includes intelligent solutions and an advanced diffusion package (PROGRES, SuperG Boost, MUSE) to automatically detect and correct distortion, artifacts, and motion in diffusion imaging. It supports advanced neuro protocols such as Human Connectome (Multi-shell DTI and high-resolution fMRI). While SIGNA Premier focuses on MRI, GE HealthCare offers broader AI solutions for neuroimaging, including CT analysis for stroke.
EEG Interpretation AI
SIGNA Premier is compatible with simultaneous EEG and fMRI studies, facilitating comprehensive neurophysiological and functional imaging research. However, direct AI for EEG interpretation is not explicitly highlighted as a feature of the SIGNA Premier system itself.
Seizure Detection
Direct AI-driven seizure detection from MRI data is not explicitly mentioned as a feature of SIGNA Premier. However, its advanced high-resolution neuroimaging capabilities can aid in identifying structural abnormalities that may be associated with epilepsy.
Neurodegenerative Disease Screening
SIGNA Premier serves as a powerful tool for imaging neurodegenerative diseases. GE HealthCare is a key partner in projects like PREDICTOM, a consortium developing a digital platform that uses AI algorithms to analyze aggregated biomarker data, including MR imaging biomarkers, for early diagnosis and prognosis of Alzheimer's disease.
Large Vessel Occlusion Detection
GE HealthCare's broader stroke solutions include AI for Large Vessel Occlusion (LVO) detection. For instance, StrokeSENS LVO (part of the FastStroke platform for CT) uses AI to identify LVOs on CT Angiography and automatically notifies the stroke team. While primarily a CT-based solution, it demonstrates GE HealthCare's comprehensive AI approach to stroke, which SIGNA Premier complements through advanced MRI.
Triage Prioritization Speed
The AI-enabled features of SIGNA Premier, such as AIR Recon DL for reduced scan times and automated applications like AIR x and AIR Touch, contribute to improved workflow efficiency and faster overall diagnosis. This acceleration in image acquisition and processing can support quicker triage prioritization in clinical settings. Additionally, GE HealthCare's FastStroke (CT-based) solution automates processing and sends results via email to stroke teams, aiding rapid communication for triage.
ASPECTS Score Automation
GE HealthCare's stroke solutions, including FastStroke with StrokeSENS (for CT), utilize validated machine-learning algorithms to automatically identify regions affected by early ischemic changes and augment physician assessment for ASPECTS scoring. Furthermore, GE HealthCare partners with Brainomix, whose e-ASPECTS tool fully automates and standardizes the ASPECTS score for non-contrast CT scans.
Mobile Notification System
GE HealthCare's broader stroke solutions, such as FastStroke, can automatically process and send generated images and results to the stroke team via email. Through partnerships like Brainomix, mobile apps on Android and iOS with push notifications are available for fast access to CT images and e-ASPECTS results.
Physician Tip

Leverage SIGNA Premier's AI-driven speed enhancements, like AIR Recon DL, to significantly reduce MRI scan times, improving patient throughput and comfort, especially in urgent neurological cases. Utilize automated applications such as AIR x and AIR Touch for consistent and efficient slice prescription and workflow. Integrate the high-resolution imaging and advanced diffusion capabilities for detailed assessment of neurodegenerative diseases and complex brain pathologies. While SIGNA Premier excels in MRI, be aware of GE HealthCare's complementary CT-based AI solutions (e.g., StrokeSENS, e-ASPECTS) for a holistic approach to stroke detection and management, including automated LVO detection and ASPECTS scoring, and their associated mobile notification systems for rapid team communication.

SIGNA Premier integrates GE HealthCare's proprietary AI technologies, including AIR Recon DL for deep learning reconstruction, and automated applications like AIR x and AIR Touch for enhanced workflow and image quality. The system's cloud-based analytics capabilities allow for future integration with advanced neuro applications. For comprehensive stroke care, GE HealthCare's ecosystem includes partnerships with solutions like Brainomix (e-ASPECTS) and Circle Neurovascular (StrokeSENS), which provide AI-driven analysis and mobile notifications, primarily for CT imaging, but are part of a broader GE HealthCare stroke portfolio.

Details

Category Neurology AI, Oncology AI, Radiology & Imaging AI
Pricing Contact vendor for pricing — N/A (medical device, not a tiered software service)
DeploymentOn-premise (physical medical device installation)
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status 1 AI-estimated

The SIGNA Premier system received 510(k) clearance (K171128, K183231) for its core functionality. The specific 510(k) K193282, cleared on April 10, 2020, was for the addition of the AIR Recon DL deep-learning-based reconstruction feature to the SIGNA Premier system.
Integrations
EHR Not specified
Specialties Neurology, Oncology, Radiology

What the Web Says

The GE Healthcare SIGNA Premier is a 3.0T wide-bore MRI system designed for advanced imaging and research, particularly in neurology and oncology. It emphasizes patient comfort with a 70cm wide bore and AIR Coils, alongside innovative technologies like SuperG gradients and deep learning reconstruction (AIR Recon DL) for enhanced image quality and speed. The system is also designed for upgradeability, allowing for future software enhancements and extended life expectancy.

Overall: Positive

Strengths

  • Exceptional image quality and precision due to SuperG gradients and AIR Recon DL.
  • Enhanced patient comfort with a 70cm wide bore and lightweight, flexible AIR Coils.
  • Advanced research capabilities, especially for neurological and oncology studies.
  • Faster scan times with technologies like HyperSense and AIR Recon DL, improving workflow and reducing patient anxiety.
  • Upgradeability and long-term sustainability through the SIGNA Premier Evo transformation, extending system life and reducing costs.
  • Automatic detection and correction of diffusion distortions, artifacts, and motion.

Limitations

  • GE's MRI software can be less user-friendly compared to competitors like Siemens, with extended prescanning and calibration times.
  • Some users on Reddit have expressed frustration with GE software for managing multiple accession numbers under the same patient.
  • Full specifications, such as exact noise ratings for different sequences, are not publicly available, which can be a concern for patients with noise sensitivity.
  • SilentScan, a noise reduction feature, may be an optional package and only works for certain sequences.

Based on reviews from: GE Healthcare, ICE Magazine, Reddit

Last updated: 2026-07-18

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Press & Coverage

Applied Radiology
GE Healthcare receives FDA clearance for SIGNAu2122 Premier MRI scanner
GE Healthcare received 510(k) clearance from the U.S. FDA for its new wide bore 3.0T magnetic resonance imaging (MRI) system, SIGNA Premier, developed in collaboration with the NFL and research institutions to aid in detecting biomarkers for mild traumatic brain injury.
2017-09
Imaging Technology News
GE Healthcare Highlights New Signa Premier MRI System at ISMRM 2017
GE Healthcare showcased its then FDA 510(k)-pending SIGNA Premier MRI system at ISMRM 2017, highlighting its SuperG gradient technology and TDI RF architecture designed for improved productivity and advanced diagnostic outcomes.
2017-04
AuntMinnie.com
GE gets FDA nod for new Signa Premier MRI - AuntMinnie
GE Healthcare received FDA 510(k) clearance for its Signa Premier MRI system, a 3-tesla, wide-bore system resulting from a $60 million collaboration with the NFL to develop imaging technologies for concussion detection.
2017-08
Insightec
Insightec receives FDA Approval & CE Mark for compatibility with GE Signa Premier
GE Healthcare and Insightec announced FDA approval and CE mark for the compatibility of Exablate Neuro, a focused ultrasound platform for incisionless brain surgery, with GE Healthcare's SIGNA Premier MRI system.
2019-07
FDA
GE Healthcare (GE Medical Systems, LLC) April 10, 2020 Mr. Glen Sabin Regulatory Affairs Director, MR 3200 N Grandview Blvd
This FDA document details the 510(k) premarket notification for the GE Healthcare SIGNA Premier system with the addition of the AIR Recon DL feature, affirming its substantial equivalence to the predicate device.
2020-04
PubMed Central (PMC)
Detecting task functional MRI activation using the multiband multi-echo EPI sequence - PMC
This peer-reviewed article describes imaging performed at 3T using a SIGNA Premier (GE Healthcare) MRI system for detecting task functional MRI activation with a multiband multi-echo EPI sequence.
2021-05
MarketScale
GE HealthCare & UC Launch the Future of MRI Research - MarketScale
GE HealthCare, the University of Cincinnati, UC Health, and Cincinnati Children's partnered to establish an MRI Research and Development Center featuring GE HealthCare's SIGNA Premier 3T scanner to accelerate next-generation MRI solutions.
2024-08
GE HealthCare
GE HealthCare Receives FDA Clearance for Head-Only SIGNA MAGNUS 3.0T MRI System
GE HealthCare received FDA 510(k) clearance for its SIGNA MAGNUS 3.0T high-performance, head-only MRI scanner, which utilizes HyperG gradient technology enabling faster image acquisition with the same power requirements as the whole-body SIGNA Premier 3.0T system.
2024-11

Videos

Product demos, reviews, and walkthroughs for SIGNA Premier.

View all on YouTube

Frequently Asked Questions

The AI in SIGNA Premier, particularly features like AIR Recon DL and Sonic DL, significantly enhances image quality by improving signal-to-noise ratio and sharpness, while also accelerating scan times by up to 50-83%. This leads to clearer images, reduced motion artifacts, and a more efficient diagnostic process, benefiting various clinical applications including neurology, oncology, and cardiac imaging.
GE Healthcare implements robust security protocols and anonymization techniques for patient data processed by AI algorithms on SIGNA Premier, adhering to stringent regulations like HIPAA. This includes ensuring data access is limited to the minimum necessary, preventing re-identification of de-identified data, and maintaining strict access controls and audit trails.
Yes, AI features like AIR Recon DL on SIGNA Premier have received FDA 510(k) clearance, with GE HealthCare also recently securing clearances for new AI-driven workflow solutions like SIGNA One. Clinical validation studies demonstrate that AIR Recon DL improves signal-to-noise ratio, image sharpness, and maintains lesion conspicuity, supporting its efficacy and safety.
SIGNA Premier's AI leverages GE Healthcare's proprietary deep learning algorithms, such as AIR Recon DL and Sonic DL, which are seamlessly integrated into the system for enhanced image quality and speed. While other major MRI vendors like Siemens, Philips, and Canon Medical offer their own AI solutions, a comprehensive comparison would involve evaluating specific applications, image quality metrics, and workflow benefits tailored to your clinical needs.
Like all AI, the algorithms in SIGNA Premier are trained on specific datasets and may have limitations in rare pathologies, certain patient populations, or in cases of poor image quality. Physicians should be aware of these potential biases and limitations, always exercising their clinical judgment and using AI-generated insights as supplementary information rather than definitive diagnoses.
The pricing structure for AI features on SIGNA Premier can vary; some core AI functionalities, like AIR Recon DL, are integral to the system and its upgrades. While specific advanced applications or future upgrades might be offered as separate licenses or subscription services, upgrading a legacy system to SIGNA Premier Evo with AI can be a cost-effective alternative to full replacement.
GE Healthcare offers comprehensive training programs for SIGNA Premier installations, including both system operation and effective utilization of AI tools. This support extends through ongoing educational resources, technical assistance, and platforms like the GE HealthCare Institute and WeConnect, ensuring users can maximize the system's capabilities.

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Suggest an Edit → | Last Verified: 2026-04-18 | First Added: 2026-04-18
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