SIGNA Premier

by GE HealthCare  · Based in United States → — Tomorrow's MR...today.
Neurology Oncology Radiology
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Regulatory Status Disclosed

Overview

The SIGNA Premier is a high-performance 3.0 Tesla (3T) wide-bore Magnetic Resonance Imaging (MRI) system from GE Healthcare. It is engineered to deliver superior image quality, enhanced patient comfort, and robust clinical capabilities for both routine diagnostic imaging and advanced research. The system features a 70cm wide bore, providing 60cm performance, and incorporates innovative technologies such as SuperG 80/200 Gradients for outstanding stability and performance.

A key advancement in the SIGNA Premier is the integration of artificial intelligence (AI) through its AIR™ Recon DL deep-learning-based reconstruction technique, which significantly improves signal-to-noise ratio (SNR), image sharpness, and enables shorter scan times. Patient experience is prioritized with revolutionary AIR™ Coils, a lightweight and flexible design that conforms comfortably to the patient’s body, and the Comfort Plus patient table. The SIGNA Premier also utilizes the SIGNA™Works productivity platform, offering a suite of applications like HyperBand, HyperSense, and HyperCube for accelerated imaging and streamlined workflows.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • 3.0T wide-bore MRI scanner (70cm bore, 60cm performance)
  • SuperG 80/200 Gradients with 1.2 km All-Hollow wire design
  • AIRu2122 Recon DL deep-learning-based reconstruction for improved SNR and sharpness
  • AIRu2122 Coils for enhanced patient comfort and signal performance
  • 146 independent RF channels for high image quality and faster scanning
  • SIGNAu2122Works productivity platform with advanced pulse sequences and workflow tools
  • HyperBand, HyperSense, and HyperCube acceleration techniques for speed
  • Comfort Plus patient table for improved patient experience and efficiency
  • Advanced diffusion package (PROGRES, SuperG Boost, MUSE) for distortion correction
  • SilentScan Technology for reduced acoustic noise

Use Cases

  • Advanced neurological imaging and research, including Human Connectome Protocol and fMRI
  • Oncology research and clinical diagnosis
  • High-resolution musculoskeletal imaging of bone, joint, and soft tissue
  • Cardiac imaging with up to 12x acceleration
  • Comprehensive body imaging, including free-breathing abdominal scans
  • Academic institutions for scientific endeavors and expanded research capabilities

What Physicians Need to Know

Brain MRI Analysis
SIGNA Premier utilizes AI and deep learning solutions, including AIR Recon DL and Sonic DL, to enhance image quality and reduce scan times for neurology applications. It offers advanced imaging techniques for precise brain anatomy, providing quantifiable and consistent results. The system also integrates with icometrix and its icobrain platform to strengthen quantitative brain MRI analysis, particularly for neurodegenerative diseases like Alzheimer's.
Neurodegenerative Disease Screening
SIGNA Premier supports quantitative brain MRI analysis through integration with the icobrain platform, which is designed to aid in personalized neurological care, especially for conditions such as Alzheimer's disease.
Large Vessel Occlusion Detection
While the SIGNA Premier is an MRI system, AI software for detecting large vessel occlusion (LVO) on CT scans has been shown to reduce triage time and improve workflow for acute stroke patients. AI tools can achieve 90-95% accuracy for identifying LVOs and analyze CT scans in 1-6 minutes.
Triage Prioritization Speed
AI software for detecting large vessel occlusion (LVO) on CT scans has been shown to reduce door-to-groin time for acute stroke patients by 11.2 minutes and time from CT scan to endovascular therapy initiation by 9.8 minutes. AI analysis of CT scans for stroke can cut door-to-notification time by 30-52%.
ASPECTS Score Automation
AI tools have demonstrated high accuracy in ASPECT scoring, with one study showing an accuracy of 88.6% for region-based analysis and 80.4% for dichotomized classification (ASPECTS ≥ 6).
Physician Tip

SIGNA Premier's AI-powered MRI capabilities, including AIR Recon DL and Sonic DL, offer significantly faster scan times and improved image quality, which can be crucial for time-sensitive neurological conditions. The integration with platforms like icobrain provides quantitative analysis for neurodegenerative diseases, aiding in personalized care. While SIGNA Premier is an MRI system, be aware that AI tools for CT scans have shown significant benefits in accelerating stroke triage and LVO detection, which can complement MRI findings in a comprehensive stroke workup. The automated slice prescription with AIR x ensures consistency in follow-up exams, which is valuable for monitoring disease progression.

The SIGNA Premier system integrates AI and deep learning solutions like AIR Recon DL and Sonic DL for accelerated image acquisition and enhanced quality. It also features AIR x for automated slice prescription. The system is designed with a workflow ecosystem, SIGNA One, to simplify operations and integrate research protocols within clinical workflows. GE HealthCare also integrates icometrix and its icobrain platform for quantitative brain MRI analysis. The Collective Minds platform can be used to review and share DICOM images from GE HealthCare clinical cases.

Details

Category Neurology AI, Oncology AI, Radiology & Imaging AI
Pricing Unknown
DeploymentOn-premise
Training Yes
Compliance
BAA Available Yes AI-estimated
HIPAA Compliant Yes AI-estimated
FDA Status Cleared AI-estimated
GDPR Yes AI-estimated
Integrations
EHR Not specified
Specialties Neurology, Oncology, Radiology

Support & Reliability

Training Provided Yes

What the Web Says

The GE Healthcare SIGNA Premier is a 3.0T wide-bore MRI system designed for both clinical and research applications, emphasizing high-precision diagnostics, advanced imaging capabilities, and patient comfort. It incorporates cutting-edge technologies like SuperG gradient coils, AIR Coils, and deep-learning reconstruction algorithms such as AIR Recon DL to enhance image quality and accelerate scan times. The system is particularly noted for its ability to perform fast brain scans and its adaptability for various patient anatomies.

Overall: Positive

Strengths

  • High-precision diagnostic results and excellent technical capabilities, especially in neurology and oncology.
  • Wide 70cm bore and AIR Coils improve patient comfort and accessibility, reducing claustrophobia.
  • Advanced AI and deep learning reconstruction algorithms (AIR Recon DL) accelerate scan times and improve image quality.
  • SuperG gradient coil technology provides ultra-high efficiency performance and stability, enabling high-resolution imaging.
  • Flexible and lightweight AIR Technology RF coils conform to the patient's body, improving signal reception and image quality.
  • Capable of performing quick brain scans within five minutes using HyperSense.

Limitations

  • MR systems are expensive, and constant technological changes necessitate significant investment for upgrades.
  • Potential for artifacts in B1 mapping in subjects with high fat content if fat spoiling is incomplete.
  • Some studies indicate that achieving complete fat spoiling requires longer TR, which may be undesirable in clinical applications.

Based on reviews from: bimedis.com, mxrimaging.com, cmrad.com, auntminnie.com, gehealthcare.com, nsmedicaldevices.com, appliedradiology.com, mskcc.org, scribd.com, ajronline.org, mdpi.com, researchgate.net, xtalks.com, acs.org, royalsocietypublishing.org, cdnsciencepub.com, uclouvain.be

Last updated: 2026-10-30

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Press & Coverage

appliedradiology.com
GE Healthcare receives FDA clearance for SIGNA™ Premier MRI scanner
GE Healthcare received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to sell its new wide bore 3.0T magnetic resonance imaging (MRI) system, SIGNA Premier, in the United States. This system is the result of a four-year collaboration with the National Football League and research institutions to develop imaging tools for detecting biomarkers for mild traumatic brain injury.
2017-09
mpo-mag.com
FDA Clears GE's SIGNA Premier 3T MRI Co-Developed with NFL
GE Healthcare announced the availability of SIGNA Premier, a new wide bore 3.0T MRI system, in the U.S. following FDA clearance. The system was developed in collaboration with the NFL and research institutions to create imaging tools for detecting biomarkers related to mild Traumatic Brain Injury.
2017-08
theicecommunity.com
GE Healthcare SIGNA Premier
The SIGNA Premier is a wide bore 3.0T MRI system designed for high performance in neurological and oncology research and clinical work. It features a short-bore, high-homogeneity magnet, powerful new gradients, and a digital RF transmit and receive architecture, powered by SuperG gradient technology.
2019-08
insightec.com
Insightec receives FDA Approval & CE Mark for compatibility with GE Signa Premier
GE Healthcare and Insightec announced FDA approval and CE mark for Exablate Neuro™ compatibility with the SIGNA™ Premier MRI system. Exablate Neuro is a focused ultrasound platform for incisionless brain treatment, with MR imaging providing anatomical surveys, patient-specific planning, and real-time thermal monitoring.
2019-07
gehealthcare.com
GE Healthcare Introduces SIGNA Experience: A New Platform of Transformative Technologies that Leverage the Power of AI and Deep-Learning in MRI Scanning
GE Healthcare launched SIGNA Experience, a platform of four synergistic technologies designed to enhance the MRI scanning experience for physicians, technologists, and patients. The cornerstone of this platform is SIGNA One, an imaging platform with a new user interface for intuitive workflow, efficiency, simplicity, and intelligent automation.
2022-11
gehealthcare.com
GE HealthCare achieves MRI portfolio milestone with FDA clearances for next-generation SIGNA MRI technology designed to enhance precision imaging and clinical efficiency
GE HealthCare announced 510(k) clearance from the U.S. FDA for three new magnetic resonance (MR) innovations: SIGNA™ Sprint with Freelium™, SIGNA™ Bolt, and SIGNA™ One. These advancements are part of GE HealthCare's strategy to deliver new innovations and differentiate its MR portfolio, addressing challenges like rising demand and workforce burnout.
2026-02
bizjournals.com
GE HealthCare prepares to deliver first of next-gen MRI machines
GE HealthCare will begin delivering its first MRI scanners using only 1% of traditional helium, the SIGNA Sprint with Freelium, in the first quarter of 2027. This product is an example of GE HealthCare's significant investment in innovation since its spin-off in 2023.
2026-07
gehealthcare.com
GE HealthCare unveils next generation SIGNA MRI technology aiming to boost efficiency enhance patient experience and advance sustainability
GE HealthCare announced the 510(k) submissions to the U.S. FDA for next-generation SIGNA™ MRI technology, including SIGNA Bolt, a new 3T MRI scanner, and SIGNA Sprint with Freelium, a new sealed magnet MRI system. Both systems are powered by SIGNA One, an AI-driven workflow solution designed to reduce inefficiencies.
2025-11

Videos

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Frequently Asked Questions

SIGNA Premier leverages AI, particularly through its AIR Recon DL and AIR x technologies, to enhance neurological imaging. AIR Recon DL is a deep-learning based reconstruction algorithm that improves image sharpness and signal-to-noise ratio, while AIR x is an automated workflow protocol for brain scanning that aims to improve consistency and productivity by reducing variability and scan setup time. These AI applications contribute to faster scan times, improved image quality, and a more streamlined workflow, ultimately aiding in diagnostic evaluations and potentially reducing patient anxiety.
The SIGNA Premier system, including its AI components like AIR Recon DL, has received regulatory clearances such as FDA 510(k) in the U.S. The system also bears the CE marking of conformity, indicating compliance with Medical Device Regulation 2017/745 in Europe, with the CE marking for SIGNA Premier issued in 2018. The operator manual provides essential information on safety warnings and regulatory compliance.
While SIGNA Premier offers integrated AI for image acquisition and reconstruction, other AI tools exist for neurological applications, often focusing on clinical decision support or post-processing. For instance, EvidenceMD is highlighted as a strong AI tool for neurology clinical decision support, and platforms like Viz.ai and RapidAI are gold standards for stroke and emergency triage by analyzing CT and MRI scans. Additionally, some AI solutions are software-based and can be added to existing scanners to reduce image noise or increase sharpness.
Specific limitations of SIGNA Premier's AI in neurology are not extensively detailed in the provided information. However, general limitations of current AI in neurology research have been noted, suggesting ongoing development in the field. The system is designed to push the boundaries of what's possible with MR, especially for neurology and oncology research, implying continuous evolution and addressing of current limitations.
SIGNA Premier prioritizes patient comfort with features like a 70 cm wide bore and Silent Scan technology, which significantly reduces acoustic noise during scans. The system also utilizes AIR Coils, which are lightweight and flexible, conforming to the patient's body for enhanced comfort and improved image quality. Additionally, faster scan times achieved through AI-powered technologies like AIR Recon DL and HyperSense can reduce the time patients spend on the table, thereby decreasing anxiety and stress.

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Suggest an Edit → | Report an issue | Last Verified: 2026-04-18 | First Added: 2026-04-18
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