syngo MBF
Overview
syngo MBF, developed by Siemens Medical Solutions USA, Inc., is a specialized software product designed for the visualization, assessment, and quantification of medical images, specifically focusing on quantitative blood flow measurements from Positron Emission Tomography (PET) images. This software operates within the MI Cardiology workflow of the broader syngo.via MI Workflows platform. It supports dynamic Rubidium-PET and dynamic Ammonia-PET images, providing clinicians with automatic and manual tools to orient and segment the myocardium. The system calculates myocardial blood flow and offers features like a normals database comparison workflow to aid in the assessment of results.
As part of the syngo.via platform, syngo MBF benefits from advanced visualization capabilities and AI-enabled features. The syngo.via platform utilizes ALPHA (Automatic Landmarking and Parsing of Human Anatomy) technology, an AI component that automatically recognizes anatomical landmarks in acquired images to accelerate reading workflows. The platform is designed for multi-modality reading, delivering fast 3D results, and enhancing diagnostic performance across various clinical fields including cardiology, oncology, and neurology. syngo.via can be integrated into existing IT environments, supporting both dedicated hardware and virtualized deployments. It also offers a subscription model for flexible access to clinical packages and continuous software innovations.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- Quantitative Myocardial Blood Flow (MBF) and Myocardial Flow Reserve (MFR) calculation
- Supports dynamic Rubidium-PET and Ammonia-PET images
- Automatic and manual myocardium orientation and segmentation tools
- Normals database comparison workflow
- Motion compensation and residual activity correction
- Multi-modality image reading (via syngo.via platform)
- AI-powered Automatic Landmarking and Parsing of Human Anatomy (ALPHA) for workflow acceleration (via syngo.via platform)
- Fast 3D results and advanced visualization
- Structured reporting capabilities
- Integration with Siemens Healthineers Digital Ecosystem via OpenApps
Use Cases
- Myocardial blood flow quantification in PET imaging
- Assessment of cardiac pathologies
- Evaluation of patient response to therapy
- Cardiac function analysis
- Diagnostic workflow enhancement in nuclear cardiology
- Radiotherapy treatment planning (images and results can be used)
Details
| Category | Cardiology AI, Radiology & Imaging AI |
| Pricing | Contact vendor — Contact Vendor for details. |
| Deployment | On-premise (dedicated hardware), Virtualized environments (VMware, Hyper-V) |
| Compliance | |
| BAA Available | Yes AI-estimated |
| HIPAA Compliant | Yes AI-estimated |
| FDA Status |
Yes AI-estimated syngo MBF, as part of syngo.via MI Workflows, received FDA 510(k) clearance (K251528) on July 3, 2025, as an automated radiological image processing software for visualization, assessment, and quantification of medical images, specifically for quantitative blood flow measurements of PET images. |
| Integrations | |
| EHR | Not specified |
| Specialties | Cardiology, Nuclear Medicine, Radiology |
What the Web Says
syngo MBF, a software component within Siemens Healthineers' syngo.via MI Workflows, is designed for advanced post-processing and quantitative analysis of multi-modality medical images, particularly in cardiology for myocardial blood flow (MBF) and coronary flow reserve (CFR) quantification. Physicians and researchers generally find it to be a valuable tool for quantitative analysis in nuclear cardiology, with good to excellent reproducibility for rest-MBF values. However, some studies indicate suboptimal agreement for stress-MBF and CFR values without motion correction. It is FDA-approved and utilizes compartmental modeling for kinetic analysis.
Overall: PositiveStrengths
- Provides advanced post-processing and quantitative analysis of multi-modality medical images (PET, CT, MR, NM).
- Supports clinical decision-making in oncology, cardiology, neurology, and radiotherapy planning.
- Offers good or excellent reproducibility for rest-MBF values.
- Can be used for myocardial blood flow (MBF) and myocardial flow reserve (MFR) quantification.
- Integrates with the syngo.via platform for a consistent user experience across different modalities and isotopes.
- Includes features like pre-fetching, ALPHA technology for organ recognition and alignment, and smart layouts to streamline workflow.
Limitations
- Suboptimal agreement for stress-MBF and CFR values without motion correction, though motion correction tools can improve reproducibility.
- Reproducibility for certain cardiac tracers can be challenging.
- Some studies have shown statistically significant differences in myocardial perfusion analysis when compared to other software packages.
- Interchangeability with other software tools may be limited in specific patient populations or for certain measurements.
- Training for syngo.via (which includes syngo MBF) may not always be sufficient, requiring users to seek additional resources.
- The software can be complex and may not be user-friendly without proper guidance.
Based on reviews from: ResearchGate, Science.gov, ScienceDirect, FDA AI/ML Device Search, Diagnostics, Volume 15, Issue 5, DOKUMEN.PUB, accessdata.fda.gov, PMC, MDPI, Open Heart, Innolitics, Which Medical Device, Siemens Healthineers USA, KLAS Research, Reddit
Last updated: 2026-07-20
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