Vitrea CT Brain Perfusion

by Canon Medical Systems (manufactured by Canon Medical Informatics, Inc.)  · Based in United States → — Harnesses the power of Vitrea Advanced Visualization and is a convenient method of assessing perfusion abnormalities within the brain.
Emergency Medicine Neurology Radiology
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Subscription-based
Regulatory Status Disclosed

Overview

Vitrea CT Brain Perfusion is an advanced application within the comprehensive Vitrea Advanced Visualization suite, developed by Vital Images, now a Canon Medical Systems Group Company. This multimodality, vendor-agnostic platform provides full-powered clinical applications for 2D, 3D, and 4D advanced visualization and analysis. It is designed to standardize and consolidate radiology IT footprints, offering a scalable enterprise solution accessible anywhere and anytime through a thin-client deployment.

Specifically, Vitrea CT Brain Perfusion aids in assessing the whole brain and evaluating perfusion deficits by displaying 4D-DSA (digital subtraction angiography) views of blood flow in the vessels and 3D perfusion maps. It supports physicians in visualizing apparent blood perfusion in brain tissue affected by acute stroke. The tool offers a streamlined workflow with automatic curve-fitting, midline correction, motion correction, and region of interest templating. It automatically calculates quantitative brain perfusion results, including Regional Cerebral Blood Volume (rCBV), Mean Transit Time (MTT), Regional Cerebral Blood Flow (rCBF), Time-to-Peak (TTP), and Delay of tissue response curve.

The system also incorporates Bayesian processing, which excels at processing low signal-to-noise ratio (SNR) images, providing clarity on parametric images used to compute summary maps. A single-view Summary Map facilitates easy communication of perfusion results. Furthermore, Vitrea Advanced Visualization includes Global Illumination, a revolutionary 3D/4D rendering technique that provides a more photorealistic view of human anatomy, enhancing collaboration and patient communication.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • 2D, 3D, and 4D advanced visualization and analysis
  • Multimodality and vendor-agnostic platform
  • Scalable enterprise deployment options (Workstation, Extend, Enterprise)
  • Accessible anywhere & anytime via thin-client solution
  • Automatic calculation of quantitative brain perfusion results (rCBV, MTT, rCBF, TTP, Delay of tissue response curve)
  • Single-view Summary Map for communicating perfusion results
  • 4D cine of DSA view for visualizing contrast flow through vessels
  • Streamlined workflow with automatic curve-fitting, midline correction, motion correction, and ROI templating
  • Bayesian processing for improved clarity in low signal-to-noise ratio images
  • Global Illumination for photorealistic 3D/4D rendering

Use Cases

  • Assessing whole brain perfusion and evaluating perfusion deficits
  • Visualizing apparent blood perfusion in brain tissue affected by acute stroke
  • Identifying ischemic penumbra (dying brain tissue) for treatment decisions
  • Supporting endovascular therapy decisions in acute ischemic stroke
  • Pre-procedural and pre-operative planning
  • Enhancing diagnostic confidence and data access in neuroimaging

What Physicians Need to Know

Stroke Detection Speed
Vitrea CT Brain Perfusion, especially with 4D scanning and automated workflows, aims to provide rapid assessment of perfusion abnormalities in acute stroke. The system can generate over 6,000 images in less than a minute, with reconstructed CT perfusion volumes available within 5 minutes from the start of scanning. Automated tools help efficiently visualize anatomy and pathology, and expert stroke post-processing options are incorporated into a fully automated workflow to save time. The goal is to individualize stroke care by providing essential data to accurately identify patients who will benefit from treatment, potentially extending the treatment window.
Brain MRI/CT Analysis
Vitrea CT Brain Perfusion offers comprehensive analysis of CT data, providing visualization of apparent blood flow, blood volume (CBV), mean transit time (MTT), regional cerebral blood flow (rCBF), time-to-peak (TTP), and time-to-maximum (Tmax). It supports both 2D and 4D CT scan data. The software utilizes automated curve-fitting, midline correction, motion correction, and region of interest templating for streamlined workflows. Bayesian processing is available, which excels at processing low signal-to-noise ratio (SNR) images to improve clarity on parametric maps. Vitrea also integrates with MR Neuro Packages, including MR Basic Stroke, MR Neuro, and MR Neuro ASL, for a multi-modality approach to neuroimaging.
Large Vessel Occlusion Detection
CT Brain Perfusion protocols are crucial for identifying large vessel occlusions (LVO) and distinguishing irreversibly infarcted core from salvageable ischemic penumbra, especially for patients presenting beyond 6 hours from last known well. The system provides perfusion maps (CBV, CBF, MTT, Tmax) that indicate the presence of acute cerebral infarcts and aid in assessing the type and extent of abnormal cerebral blood flow. This information is vital for determining eligibility for mechanical thrombectomy.
Triage Prioritization Speed
Canon's Automation Platform, which works with Vitrea Advanced Visualization, offers an AI-based, zero-click solution to streamline workflows by triaging and prioritizing patients. This platform delivers fast communication and accurate results, seamlessly integrating with current applications. The quick availability of analyzed brain perfusion maps, including indications of large vessel occlusion or intracranial hemorrhage, significantly impacts the team, especially during night-time.
ASPECTS Score Automation
While Vitrea CT Brain Perfusion focuses on generating detailed perfusion maps and quantitative results, studies have compared its Bayesian CTP algorithm with other software for predicting infarct and penumbra volumes. Automated ASPECTS (Alberta Stroke Program Early CT Score) has shown excellent agreement with consensus reads and CTP-CBV ASPECTS in other systems, suggesting the potential for automated scoring in conjunction with perfusion analysis.
Mobile Notification System
The Automation Platform offers a mobile app for Stroke CT/MR, which provides automated real-time alerts and notifications. This app allows cases to be viewed easily from any location, enabling quick access to information and interactive viewing of images and results. It supports multiple AI applications and features a simple, easy-to-use interface, without transmitting Protected Health Information (PHI).
Physician Tip

Leverage the automated tools for curve-fitting, motion correction, and region of interest templating to streamline your workflow and ensure consistent analysis. Utilize the Bayesian processing method, especially for low SNR images, to enhance clarity and diagnostic confidence. Integrate the perfusion maps (CBV, CBF, MTT, Tmax) with clinical context to differentiate between irreversibly infarcted core and salvageable penumbra, guiding treatment decisions for acute ischemic stroke. For patients with large vessel occlusion, particularly in extended time windows, CT Brain Perfusion is crucial for determining eligibility for mechanical thrombectomy. Consider the use of the mobile app for real-time alerts and remote access to images and results, especially for urgent stroke cases.

Vitrea Advanced Visualization is a multi-modality, vendor-agnostic platform designed for seamless integration across various modalities and clinical service lines. It integrates with Canon's Automation Platform, an AI-based solution that streamlines workflows by triaging and prioritizing patients and providing automated post-processing analysis. The Automation Platform also offers an automatic result module, Insights Results, which collects and displays analysis results from individual post-processing applications and enables sharing of DICOM-compliant reports. Vitrea also has expanded integration capabilities, including support for multi-volume fusion for 4D brain perfusion and integration with other CAD applications.

Details

Category Neurology AI, Radiology & Imaging AI
Pricing Subscription-based
Free Trial No
DeploymentOn-premise (Vitrea Advanced Visualization is a multi-modality system providing comprehensive applications in a variety of IT environments)
Data ExportUnknown
TrainingUnknown
Compliance
BAA AvailableUnknown
HIPAA CompliantUnknown
FDA Status Cleared AI-estimated
Integrations
EHR Not specified
Specialties Emergency Medicine, Neurology, Radiology

Support & Reliability

Training ProvidedUnknown

What the Web Says

Vitrea CT Brain Perfusion is a software application designed to assist physicians in visualizing apparent blood perfusion in brain tissue affected by acute stroke, aiding in the detection of acute cerebral infarcts and the assessment of penumbra and infarct volumes. It offers both 2D and 4D perfusion capabilities, with automated tools for streamlined workflow and quantitative results. Studies have compared Vitrea's accuracy in predicting infarct and penumbra volumes against other software like RAPID and Sphere, with varied results depending on the treatment cohort (intervention vs. conservative).

Overall: Mixed

Strengths

  • Aids in visualizing apparent blood perfusion in acute stroke.
  • Helps determine the presence of acute cerebral infarcts.
  • Assists in assessing penumbra and infarct volumes.
  • Offers streamlined workflow with automated features like curve-fitting, motion correction, and ROI templating.
  • Provides quantitative results for various perfusion parameters (CBF, CBV, MTT, TTP, Tmax).
  • Can be more accurate in penumbra assessment for conservatively treated patients compared to other software.

Limitations

  • May overestimate infarct volume in patients undergoing intervention.
  • All software, including Vitrea, tends to overestimate penumbra.
  • Network infrastructure can be a bottleneck, impacting processing and transfer times, especially in teleradiology settings.
  • CTP predictability of final infarct volume remains moderate across various software packages.
  • Requires careful consideration of acquisition and processing times in stroke workups, particularly in smaller departments.
  • Some physicians on Reddit question the necessity of CTP for every stroke code, especially with newer trials showing benefits of thrombectomy in large core infarcts.

Based on reviews from: Reddit, PubMed, FDA, Canon Medical Systems USA, ResearchGate, Canon Medical Systems Europe, Viz.ai, Canon Medical Systems Canada Limited, MDPI, YouTube

Last updated: 2026-07-20

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Press & Coverage

Encyclopedia.pub
Artificial Intelligence and Machine Learning in Stroke Care
Vitrea CT Brain Perfusion received FDA approval in November 2018 for quantifying cerebral blood flow and predicting final infarct volumes. Studies suggest it outperforms Rapid-CTP in predicting final infarct volumes, using human interpretation of DWI/FLAIR imaging as the gold standard.
2023-06
MDPI (Journal of Clinical Medicine)
Artificial Intelligence and Machine Learning in the Diagnosis and Management of Stroke: A Narrative Review of United States Food and Drug Administration-Approved Technologies
Vitrea CT Brain Perfusion was FDA approved in November 2018 to quantify cerebral blood flow and predict final infarct volumes, with multiple groups finding it outperforms Rapid-CTP in these predictions. This article reviews FDA-approved AI/ML technologies for stroke diagnosis and management.
2023-05
SciOpen
Implications of Artificial Intelligence in Stroke Intervention and Care
Vitrea CT Brain Perfusion is a non-invasive post-processing tool used to assess brain perfusion, calculating cerebral blood volume, flow, and mean transit time from dynamic CT image data. It aids physicians in visualizing apparent blood perfusion in brain tissue affected by acute ischemic stroke.
2025-04
British Journal of Radiology
Artificial intelligence in neuroradiology: a review of Food and Drug Administration-regulated algorithms
Vitrea CT Brain Perfusion, developed by Canon Vital Images, Inc., is an FDA-cleared algorithm (November 20, 2018) for processing CT perfusion data. This review categorizes and summarizes FDA-cleared AI algorithms in neuroradiology, highlighting their functions and performance.
2026-05
Diagnostics (MDPI AG)
Understanding CT Perfusion in Acute Ischemic Stroke: How Algorithms Shape Perfusion Maps
This journal article, published in 2026, discusses how CT perfusion algorithms influence the estimation of ischemic core and hypoperfused tissue in acute ischemic stroke, mentioning Vitrea CT Brain Perfusion in the context of FDA premarket notifications.
2026-12
accessdata.fda.gov (FDA)
Class 2 Device Recall Vitrea
This FDA recall notice details a Class 2 recall for Vitrea CT Brain Perfusion (versions 6.0 and above) due to potential user confusion when viewing brain perfusion scans acquired with wide coverage shuttle acquisition techniques, which could lead to misdiagnosis or treatment delays.
2026-06
BfArM
Urgent Safety Notice for Vitrea CT Brain Perfusion 2D, Vital Images, Inc.
Vital Images, Inc. issued a Field Safety Notice regarding a device limitation of the Vitrea CT Brain Perfusion 2D application (version 6.0 and above) due to potential inaccurate perfusion maps if data is acquired by an unsupported CT scanner.
2013-04
Canon Medical Informatics
Vitreau00ae Advanced Visualization 7.15.8.SU01 Release Notes
These release notes from January 2020 highlight enhancements to Vitrea CT Brain Perfusion, including improvements in processing speed and collage batch resolution.
2020-01

Videos

Product demos, reviews, and walkthroughs for Vitrea CT Brain Perfusion.

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Frequently Asked Questions

Vitrea CT Brain Perfusion utilizes AI and automation to streamline workflows and enhance diagnostic precision in stroke assessment. It provides automated calculations of quantitative brain perfusion parameters like rCBV, MTT, rCBF, and TTP, and employs Bayesian processing for improved image clarity, even in low signal-to-noise ratio images.
Vitrea Advanced Visualization, which includes CT Brain Perfusion, is a medical diagnostic system with FDA clearance, indicating its regulatory compliance for clinical use. Canon Medical Informatics emphasizes data control and regulatory adherence, and the platform supports deployment in privately managed cloud environments to help maintain data security and HIPAA compliance.
Vitrea CT Brain Perfusion is one of several AI-powered solutions, with alternatives including RAPID, syngo.via, IntelliSpace Portal, and Viz.ai. Studies comparing these platforms show varying accuracy in infarct and penumbra volume estimations, with Vitrea demonstrating comparable or superior performance in certain assessments depending on the clinical context.
Specific pricing for Vitrea CT Brain Perfusion is generally not publicly disclosed, as it is often part of the broader Vitrea Advanced Visualization enterprise platform. However, Canon Medical Informatics aims to provide cost-efficient access and predictable costs, especially when deployed in customer-managed cloud environments.
Limitations include potential variability in calculated core volumes due to differences in processing techniques and thresholds, and the possibility of over- or underestimation of infarct/penumbra compared to follow-up imaging. Physicians should integrate AI results with comprehensive clinical and other imaging data, as factors like patient motion or contrast injection speed can impact AI accuracy.
Vitrea Advanced Visualization is designed for seamless integration with existing systems like EHRs and PACS, optimizing interoperability within healthcare IT environments. While cybersecurity vulnerabilities have been identified in related Vitrea products in the past, Canon Medical has developed patches, underscoring the ongoing need for robust security measures and updates to protect patient information.

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Suggest an Edit → | Report an issue | Last Verified: 2026-04-19 | First Added: 2026-04-19
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