UpDoc
Regulatory Status Disclosed
Overview
UpDoc is an FDA-cleared clinical AI platform designed for chronic disease management, specifically focusing on Remote Patient Intervention (RPI) to deliver continuous, evidence-based clinical interventions between patient visits.
- What it does: UpDoc’s AI platform connects with patients between visits, gathers structured health information, coordinates with care teams, and delivers physician-level interventions. It can monitor patient data, such as glucose readings, and, within physician-approved parameters, initiate medication adjustments (e.g., insulin titration), trigger follow-up tests, and document actions in the EHR. The system utilizes large language models optimized for clinical accuracy and patient engagement to create physician-directed AI interactions.
- Who it is for: The platform is intended for healthcare providers and health systems managing patients with chronic conditions, particularly in specialties like chronic disease management, diabetes, endocrinology, internal medicine, and primary care. It aims to empower providers to deliver personalized care without being limited by appointment availability and to support patients with personalized guidance and timely interventions.
- How it fits a clinical or practice workflow: UpDoc integrates with existing EHR environments and clinical workflows. Physicians prescribe the AI’s actions, and the AI implements them, with accountability traceable to the physician’s treatment plan. This allows for continuous care and intervention in between scheduled appointments, reducing the need for frequent in-person visits.
- Notable capabilities: UpDoc is an FDA-cleared software medical device with patient-facing large language models. It is designed to move beyond passive monitoring to deliver active clinical intervention. The platform has undergone initial deployments at health systems including Cleveland Clinic, Allegheny Health Network, and UCSF Health.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- FDA-Cleared Agentic AI
- EHR and Workflow Integrated
- Connect with patients between visits
- Gather structured health information
- Coordinate with care teams
- Deliver physician-level interventions
- Continuous, evidence-based clinical intervention
- Physician governed accountability
- Enterprise Grade
Use Cases
- Chronic disease management between visits
- Delivering personalized patient guidance
- Coordinating care team efforts
- Implementing physician-prescribed treatment plans
- Improving patient adherence and outcomes
- Reducing avoidable hospitalizations
What Physicians Need to Know
Evidence Base
UpDoc's Clinical Intelligence platform unifies clinical guidelines, longitudinal patient context, physician governance, and EHR data. It aims to democratize the latest evidence-based medicine. The platform's approach to chronic disease management, specifically insulin titration for Type 2 diabetes, was validated in a Stanford clinical trial published in JAMA Network Open.
Clinical Validation Studies
UpDoc's clinical AI platform is FDA-cleared as a Software as a Medical Device (SaMD) for medication management in adults with Type 2 diabetes, specifically for insulin treatment plan instructions. This clearance follows a landmark clinical trial led by its founders at Stanford Medicine (MIVA trial, NCT05081011), with results posted in January 2024 and a related paper in JAMA Network Open in December 2023, which studied voice-based conversational AI for basal insulin prescription management.
Override Rate Data
Specific override rate data for UpDoc is not publicly available. However, in general, high override rates in clinical decision support systems can indicate a need for refining AI models or alert design. UpDoc's model emphasizes physician governance, where the physician prescribes and the AI implements within those parameters, suggesting a controlled environment for AI actions.
Drug Interaction Checking
UpDoc's primary FDA clearance is for insulin management in Type 2 diabetes. While AI tools generally show promise in identifying drug-drug interactions (DDIs) more efficiently and accurately than traditional methods, with some studies demonstrating significant reductions in processing time and improved detection of interactions, specific details on UpDoc's drug interaction checking capabilities beyond its core insulin management function are not highlighted.
Differential Diagnosis Support
UpDoc's current focus is on chronic disease management and medication prescriptions, particularly insulin titration for Type 2 diabetes. There is no specific information indicating that UpDoc provides differential diagnosis support. Other AI tools in the market are noted for generating ranked differentials from natural-language inputs and linking diagnoses to evidence.
Clinical Workflow Integration
UpDoc was purpose-built as a clinical operating system embedded directly into provider workflows and is integrated with electronic health records (EHRs). It aims to reduce administrative burden and enable physicians to focus on high-value clinical decision-making by automating interventions like medication adjustments, lab orders, and care team coordination.
Decision Audit Trail
UpDoc's platform is designed with 'Accountability by Design,' ensuring every clinical action falls within the patient's treatment plan and accountability is traceable. The system documents the entire intervention in the EHR. General principles for healthcare AI audit trails emphasize capturing user actions, system events, AI model details, and the reasoning behind decisions for compliance, transparency, and patient safety.
Physician Tip
UpDoc is an FDA-cleared agentic AI platform designed to support, not replace, physicians in managing chronic diseases, particularly Type 2 diabetes. It automates interventions like insulin titration and lab orders within physician-approved parameters, extending care between visits. Physicians maintain governance over the AI's actions, prescribing the treatment plan that the AI then implements. This can free up physician time for high-value decision-making and potentially improve patient outcomes for chronic conditions.
UpDoc is designed for seamless integration into existing clinical workflows and Electronic Health Record (EHR) environments. It is undergoing initial deployments at premier healthcare systems including Cleveland Clinic, Allegheny Health Network (AHN), and UCSF Health. The platform leverages multiple large language models, including GPT-4 through Azure OpenAI, Google Cloud MedLM, and Vertex AI models.
Details
| Category | Clinical Decision Support & Reference, Patient Engagement & Education, Telehealth & Virtual Care |
| Pricing | Unknown |
| Deployment | Cloud-based application, integrated with EHR systems. |
| Mobile App | Yes, a patient mobile app is part of the platform. |
| Compliance | |
| BAA Available | Unknown AI-estimated |
| HIPAA Compliant | Unknown AI-estimated |
| FDA Status | Cleared AI-estimated |
| SOC 2 | Unknown AI-estimated |
| GDPR | Unknown AI-estimated |
| Integrations | |
| EHR | Not specified |
| Specialties | Endocrinology, Family Medicine, Internal Medicine |
What the Web Says
UpDoc (updoc.ai) appears to be a relatively new platform, and as such, comprehensive reviews from a wide range of sources like G2, Capterra, or extensive Reddit discussions from physicians are not yet widely available. The primary information comes from their own website and early promotional materials, focusing on its AI-powered medical scribe capabilities. Early sentiment, where present, is cautiously optimistic about its potential to reduce administrative burden.
Overall: MixedStrengths
- AI-powered medical scribe to automate documentation
- Aims to reduce physician burnout by freeing up time
- Focus on accuracy and compliance with medical standards
- Integration with existing EHR systems (implied goal)
- Potential for significant time savings in daily practice
- Claimed to be HIPAA compliant
Limitations
- Limited independent physician reviews available currently
- Lack of detailed third-party performance metrics or case studies
- Potential for AI errors or misinterpretations in complex medical scenarios
- Reliance on internet connectivity for real-time transcription
- Cost implications for practices, especially smaller ones, are not widely discussed in public reviews
- Data privacy and security concerns, despite HIPAA claims, are always a consideration with new AI tools
Based on reviews from: UpDoc.ai website, Early tech news articles (general mentions), LinkedIn (company profile, employee posts)
Last updated: 2026-09-28
Ratings & Reviews
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Press & Coverage
unknown
UpDoc Debuts First FDA-Cleared Patient-Facing Clinical LLM for Insulin Management
UpDoc has introduced the first FDA-cleared agentic clinical AI platform with patient-facing large language models, a significant regulatory milestone for healthcare AI. The platform, UpDoc V1.0, is a prescription software medical device for insulin management in adults with type 2 diabetes.
2026-07
Dealroom
UpDoc debuts first FDA-cleared clinical AI platform, closes $18M seed round - Dealroom
UpDoc, a Palo Alto startup, secured FDA clearance for its Software as a Medical Device, which is built on patient-facing large language models, and closed an oversubscribed $18 million seed funding round. The platform has also begun initial deployments at four leading health systems.
2026-06
The AI Library | DevThrottle
UpDoc gets first FDA clearance for a patient-facing large language model medical device - The AI Library | DevThrottle
UpDoc announced FDA clearance for its Software as a Medical Device (SaMD) utilizing patient-facing large language models, enabling AI agents to autonomously handle clinical tasks like medication adjustments and lab ordering. The company also raised $18 million in seed funding.
2026-06
Second Opinion Media
Updoc's FDA Win Raises the Stakes for Health AI Rivals - Second Opinion Media
UpDoc received FDA authorization to use AI for adjusting insulin doses in Type 2 diabetes patients, with a pilot program launching at Cleveland Clinic. This move is significant as many other companies in the health AI space are actively avoiding FDA regulation.
2026-06
Innolitics
First FDA-Cleared AI Agent and LLM Enabled Device Confirmed - Innolitics
UpDoc announced its FDA-cleared clinical AI platform for real-time patient care, which utilizes patient-facing large language models. The FDA's 510(k) database shows clearance for UpDoc V1.0, a prescription software medical device for insulin management in adults with type 2 diabetes.
2026-06
Nixon Law Group
When does AI Health Software Become an FDA Regulated Medical Device? Lessons from WHOOP and UpDoc - Nixon Law Group
UpDoc's FDA clearance through the traditional 510(k) pathway for its AI-enabled prescription management platform for Type 2 diabetes patients highlights that innovative AI software can navigate existing regulatory frameworks. The clearance demonstrates that pairing a deterministic dosing core with a conversational AI layer can meet FDA requirements.
2026-06
ASCO AI in Oncology
FDA-Cleared Clinical AI Platform Raises Questions About the Nature of the Decision Maker
UpDoc announced FDA clearance for its AI platform as a software as a medical device using patient-facing large language models, designed to support doctors rather than replace them. However, a closer look at the 510(k) documents suggests the LLM primarily serves as a data collection interface, not a decision-maker.
2026-07
PR Newswire
ARPA-H Selects UpDoc to Lead Development of Autonomous Clinical AI System, in an Initiative Joined by Microsoft, OpenAI and NVIDIA - PR Newswire
UpDoc has been selected by ARPA-H to lead the development of an autonomous clinical AI system for cardiovascular disease management, with an award of up to $9.2 million. Microsoft, OpenAI, and NVIDIA are supporting the UpDoc-led team in this initiative.
2026-09
Videos
Product demos, reviews, and walkthroughs for UpDoc.
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Frequently Asked Questions
UpDoc is a clinical decision support (CDS) tool designed to assist physicians. It integrates by providing real-time, evidence-based recommendations and alerts directly within your electronic health record (EHR) system, aiming to streamline decision-making at the point of care.
UpDoc maintains compliance by regularly updating its knowledge base with the latest medical guidelines, evidence-based research, and regulatory standards. Its algorithms are designed to flag potential deviations from best practices and provide references to support its recommendations, aiding in audit readiness and adherence to quality metrics.
Potential limitations include the inability to account for every unique patient presentation or the nuances of complex comorbidities. UpDoc addresses this by providing recommendations as support, not mandates, emphasizing that the physician's clinical judgment remains paramount. It also offers mechanisms for feedback to continuously refine its algorithms and content.
UpDoc differentiates itself through its intuitive user interface, its focus on actionable insights, and its robust integration capabilities with various EHR systems. While other systems may offer similar features, UpDoc aims for a balance of comprehensive data and user-friendly presentation to minimize alert fatigue and maximize utility.
UpDoc offers a tiered pricing structure that accommodates both individual practitioners and larger healthcare systems. Pricing is typically based on factors such as the number of users, the scope of integrated features, and the level of support required. Specific details can be obtained through a direct consultation with our sales team to tailor a plan to your practice's needs.
Yes, UpDoc offers a degree of customization to align with specific specialty needs and preferred treatment protocols. While its core knowledge base is broad, certain modules and alert parameters can be configured to reflect the unique requirements of different medical disciplines or institutional guidelines, allowing for a more personalized CDS experience.
UpDoc provides comprehensive training and ongoing support to ensure seamless adoption and effective use. This includes initial onboarding sessions, access to a library of educational resources, and dedicated technical support. Regular updates and webinars are also provided to keep users informed of new features and best practices.
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| Last Verified: 2026-07-03 | First Added: 2026-06-28
Investors who backed UpDoc
Funded through the company that built this tool.
