Products

cNeuro cMRI
Combinostics Oy
Neurology AI
cNeuro cMRI is a cloud-based AI software for fully automated brain MRI quantification, providing objective data and high-quality reports for neurological disorders like dementia, MS, TBI, and epilepsy.

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About Combinostics Oy

Combinostics Oy is a Finnish healthcare AI company that develops and markets advanced tools for data-driven diagnostics, primarily focusing on neurological disorders. Their flagship product, the cNeuro® platform, offers a suite of AI-powered applications designed to assist clinicians in the early detection, differential diagnosis, and ongoing management of conditions such as Alzheimer’s disease, other dementias, multiple sclerosis, traumatic brain injuries, and epilepsy.

The cNeuro platform integrates imaging data with clinical information to provide a comprehensive and intuitive view of patient data. Key applications include cNeuro® cMRI™ for automated quantification of brain MRI scans, cNeuro® cDSI™ for data-driven clinical decision support by combining imaging and clinical biomarkers with a database of previously diagnosed patients, cNeuro® cPET™ for automated FDG and amyloid PET quantification, and cNeuro® cDAT™ for automated quantification of DAT SPECT images to aid in the diagnosis of Parkinson’s disease and Dementia with Lewy Bodies. These tools aim to enhance diagnostic accuracy, improve treatment choices, and ultimately improve the quality of life for patients with neurological disorders.

Focus Areas

neurodegenerative diseases Alzheimer's disease dementia multiple sclerosis traumatic brain injury epilepsy AI-powered diagnostics medical imaging quantification clinical decision support

Business Intelligence

Technologycloud-based, AI-driven platform (cNeuro)

What Physicians Need to Know

Neurological Disorders & Early Detection
Combinostics specializes in providing AI-powered solutions for the early detection, differential diagnosis, and management of major neurological disorders, including dementia, Alzheimer's disease, multiple sclerosis, traumatic brain injury, and epilepsy.
Dementia & Differential Diagnosis
Their cNeuro® suite, particularly the cDSI™ application, offers an industry-first Dementia Differential Analysis report. This report uses proprietary machine learning to compare patient MRI biomarkers against data from over 2,000 patients with confirmed neurodegenerative diseases (Alzheimer's, frontotemporal, vascular dementia) and cognitively normal individuals, providing probabilities for different diagnoses.
MRI & PET Quantification
Combinostics offers automated quantification of brain MRI scans (cMRI™) to objectively measure atrophy in different brain regions and white matter hyperintensities. They also have a pending cPET™ application and a cDAT™ application for quantifying DAT SPECT images, extending their solutions across the patient pathway.
Clinical Decision Support & AI in Neurology
Their AI-powered cNeuro® platform integrates imaging data with other clinical information (demographics, cognitive testing, CSF biomarkers) to provide data-driven clinical decision support for early and differential diagnosis, prediction of disease progression, and treatment planning.
Physician Tip

Combinostics' solutions empower physicians with objective, reliable, and evidence-based insights for confident diagnostic and management decisions. The AI-powered quantification of MRI and PET scans helps identify subtle changes difficult to assess visually, leading to earlier and more accurate diagnoses. The Dementia Differential Analysis report is particularly valuable for distinguishing between different types of dementia. The integration of various patient data points provides a holistic view, aiding in treatment planning, monitoring disease progression, and making informed decisions about additional testing. The clinically focused reports also facilitate better communication between radiologists, neurologists, patients, and caregivers.

The cNeuro® platform is cloud-based and designed to integrate cMRI™ and cDSI™ applications with multiple external data sources. Combinostics has partnered with ConcertAI's TeraRecon to make their cMRI™ solution available within the Eureka Clinical AI platform, enhancing seamless workflow integration for approximately 1900 health sites globally. The cDSI application can combine imaging and other biomarkers, clinical tests, neuropsychological tests, and demographic data.

Products by Combinostics Oy

1 product in the directory

cNeuro cMRI
Combinostics Oy
Neurology AI
cNeuro cMRI is a cloud-based AI software for fully automated brain MRI quantification, providing objective data and high-quality reports for neurological disorders like dementia, MS, TBI, and epilepsy.

What the Web Says

Combinostics Oy is a Finnish company specializing in AI-powered solutions for neurological disorders, particularly in the diagnosis and management of dementia and multiple sclerosis. Their flagship product, cNeuro, offers multimodal clinical decision support tools that integrate brain MRI analysis with other clinical data. The company was acquired by SyntheticMR in November 2024. While specific user reviews from platforms like G2, Glassdoor, Capterra, and Reddit are not readily available, the company's products are highlighted for their ability to provide objective data and support early diagnosis and efficient management of neurodegenerative diseases.

Overall: Mixed

Strengths

  • AI-driven, cloud-based diagnostics for neurological disorders.
  • Integrates brain MRI analysis with clinical data like CSF results.
  • Supports early diagnosis and efficient management of neurodegenerative diseases.
  • Provides quantified information for differential diagnosis and assessing cognitive issues.
  • Enhances workflow for radiologists and provides detailed reports.
  • Facilitates communication between radiologists and clinicians.

Limitations

  • Limited public reviews available on major platforms like G2, Glassdoor, Capterra, and Reddit.
  • Acquisition by SyntheticMR for less than it raised suggests potential financial challenges prior to the merger.
  • The broader funding environment has been challenging for healthtech AI startups without strong commercial traction.
  • SyntheticMR's reported revenue decline could pose short-term challenges for the combined company.

Based on reviews from: Combinostics Official Website, Medium (Amine Korchi MD), Medical Technology Yearbook, Medical Technology Issue 32, accessdata.fda.gov

Last updated: 2026-10-20

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Press & Coverage

Combinostics
Combinostics and SyntheticMR to join forces
Combinostics announced an agreement with SyntheticMR for SyntheticMR to acquire all shares in Combinostics, subject to approval by an Extraordinary General Meeting.
2024-11
Combinostics
Combinostics new PET quantification application cNeuro cPET receives FDA 510(k) clearance
Combinostics' new cPET application for amyloid and FDG brain PET quantification has received FDA 510(k) clearance, expanding its solutions for neurological disorders.
2023-09
Combinostics
Combinostics cNeuro cDAT application for quantification of DAT SPECT images released in Europe
Combinostics has released its new cDAT application in Europe for automated quantification of DAT SPECT images, further extending its solutions for neurological disorders.
2023-12
Combinostics
Revolutionising Precision Medicine: PROMINENT Project will Enhance Diagnosis and Treatment of Neurodegenerative Diseases, Improving Patients' Lives Across Europe
The PROMINENT project, involving Combinostics, launched to enhance the diagnosis and treatment of neurodegenerative diseases across Europe.
2023-06
Combinostics
Combinostics' cDSI and cMRI Applications, Part of the cNeuro Platform, Receive EC-certification Under the EU's Medical Device Regulation (MDR)
Combinostics' cNeuro cDSI and cMRI applications have achieved EC-certification under the EU's Medical Device Regulation (MDR), ensuring continued service to European customers.
2022-06
Combinostics
Combinostics Announces an Industry-First Report Supporting the Differential Diagnosis of Dementias
Combinostics announced a new report supporting the differential diagnosis of dementias, leveraging its AI-powered cNeuro suite of products.
2022-05
Combinostics
Combinostics raises €3.9M to support early Alzheimer's diagnosis
Combinostics closed a €3.9M Series A funding round, led by Industrifonden and NordicNinja VC, to scale its platform for early-stage Alzheimer's diagnosis in the US and Asia.
2019-11
PLOS One
Computerized decision support is an effective approach to select memory clinic patients for amyloid-PET | PLOS One
A research article in PLOS One discusses the effectiveness of computerized decision support, with Combinostics Oy owning some of the intellectual property.
2024-05

Frequently Asked Questions

Combinostics' cNeuro® platform provides AI-powered tools for the early detection and differential diagnosis of various neurological disorders, including Alzheimer's disease and other dementias, multiple sclerosis, traumatic brain injury, and epilepsy. The platform analyzes MRI and PET imaging data to provide quantitative insights relevant to these conditions.
The cNeuro® platform utilizes AI to quantify subtle changes in brain MRI and PET scans, which can be indicative of neurological disorders even in early stages. This quantitative analysis aids physicians in differentiating between various conditions that may present with similar symptoms, leading to more accurate and timely diagnoses.
Combinostics' primary product is the cNeuro® platform, which includes modules for MRI and PET quantification. These modules provide automated analysis of imaging data, offering metrics and visualizations that support clinical decision-making for a range of neurological conditions.
Combinostics' cNeuro® platform is CE marked as a Class IIa medical device in Europe and has FDA 510(k) clearance in the United States, ensuring it meets stringent regulatory requirements for safety and efficacy in clinical use.
Combinostics develops its AI algorithms using extensive, diverse datasets and employs rigorous validation processes to ensure accuracy and minimize bias. The cNeuro® platform is designed as a clinical decision support tool, meaning the final diagnostic interpretation remains with the physician, integrating AI insights with clinical expertise.
Combinostics typically offers its cNeuro® platform through a subscription-based model, with pricing varying based on the modules and usage volume. They provide comprehensive support, including training, technical assistance, and ongoing updates to ensure seamless integration and optimal performance for healthcare providers.
Combinostics collaborates with leading research institutions, pharmaceutical companies, and healthcare providers to further develop and integrate its AI solutions in neurology. The company is privately held, venture-backed, and continues to expand its global presence, indicating a stable and growth-oriented outlook in the medical AI market.

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