UpDoc Inc.

by UpDoc Inc.  · Based in United States → — AI that delivers clinician-level care
Cardiology Endocrinology Nephrology
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Tiered subscription
Regulatory Status Disclosed

Overview

UpDoc is an FDA-cleared, enterprise-ready agentic clinical AI platform designed to enable clinicians to deploy AI agents integrated with EHRs and other workflows for care-related tasks. It focuses on closing the loop between patient visits, providing continuous, evidence-based clinical intervention, particularly for chronic disease management.

The platform is built for enterprise health systems, integrating with existing EHR environments and clinical workflows while adhering to compliance requirements. It aims to empower providers to deliver high-touch, personalized care without being limited by traditional constraints like appointment wait times or clinic capacity.

For patients, UpDoc delivers personalized guidance and timely clinical intervention, addressing the critical period between appointments where chronic conditions often progress. For payers, it promises earlier intervention, higher adherence, and durable outcomes at a reduced cost compared to traditional care models.

UpDoc’s approach is physician-governed, ensuring that every clinical action falls within the patient’s prescribed treatment plan, with clear accountability. The AI implements interventions based on physician orders, making accountability traceable.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • FDA-cleared agentic clinical AI
  • EHR and workflow integration
  • Continuous, evidence-based clinical intervention
  • Physician-governed AI actions
  • Structured health information gathering
  • Coordination with care teams
  • Personalized patient guidance
  • Chronic disease management
  • Patient-facing LLM

Use Cases

  • Managing chronic diseases between visits
  • Delivering personalized patient interventions
  • Gathering structured patient health data
  • Coordinating care team activities
  • Improving medication adherence
  • Reducing avoidable hospitalizations

What Physicians Need to Know

Evidence Base
UpDoc's platform is built on evidence-based medicine, leveraging clinical guidelines and the latest research. It was developed by physicians and aims to democratize access to high-quality, evidence-based care. The platform's approach to chronic disease management, specifically Remote Patient Intervention (RPI), was first conducted in a Stanford clinical trial published in JAMA Network Open, demonstrating significant improvements in diabetes control.
Clinical Validation Studies
UpDoc's platform has undergone clinical validation through trials. A landmark clinical trial led by its founders at Stanford Medicine provided the clinical foundation for the FDA-cleared solution. This study showed that 81% of AI-managed patients achieved glycemic control at 8 weeks, compared to 25% with traditional care, and demonstrated 60% greater medication adherence. The AI group in the Stanford study achieved target blood glucose in 15 days, while less than half of the standard care group reached it within an 8-week period.
Alert Fatigue Management
While not explicitly detailed as 'alert fatigue management,' UpDoc's design focuses on seamless integration into existing clinical workflows to reduce administrative burden and allow physicians to focus on high-value decision-making. The platform aims to provide continuous, evidence-based clinical intervention between visits, reducing the need for frequent in-person appointments.
Override Rate Data
UpDoc's system is designed with physician governance, meaning clinical actions fall within physician-approved parameters, and accountability is traceable. While specific override rate data is not publicly detailed, the FDA clearance process for LLM-based SaMDs requires showing evidence on clinician-override effectiveness (i.e., whether the human actually catches the bad output).
Drug Interaction Checking
UpDoc's FDA-cleared product, UpDoc V1.0, is a prescription software medical device intended to support insulin management for adults with type 2 diabetes, including insulin titration guidance. The platform can initiate titration of insulin regimens within physician-approved parameters. While the primary focus is on medication management, particularly insulin, the provided information does not explicitly detail a comprehensive drug interaction checking feature akin to tools like Lexicomp or UpToDate's drug interaction checker.
Differential Diagnosis Support
UpDoc's platform is described as supporting clinical decision-making, particularly for medication management and chronic disease management. However, the FDA clearance for UpDoc V1.0, while using patient-facing large language models, does not interpret or diagnose symptoms; instead, it enables patients to log symptoms that are considered when generating treatment plan instructions. The software operates within tightly specified boundaries designed to support clinical decision-making rather than functioning as a general-purpose medical chatbot.
Guideline Update Frequency
UpDoc's platform unifies clinical guidelines as part of its proprietary orchestration and safety architecture. The company's clinical governance framework encourages partner doctors to integrate the latest research and clinical guidelines into their care delivery. However, specific details on the automated update frequency of these guidelines within the AI platform are not explicitly provided.
Clinical Workflow Integration
UpDoc was purpose-built as a clinical operating system embedded directly into provider workflows. It integrates seamlessly into existing EHR environments and compliance frameworks. The platform is designed to extend clinicians' reach between scheduled visits, delivering care as an integral member of the care team. It aims to reduce administrative burden and enable physicians to devote more time to high-value clinical decision-making.
Decision Audit Trail
UpDoc's platform emphasizes accountability by design, ensuring every clinical action falls within the patient's treatment plan and is traceable. The system documents the entire intervention in the EHR. For FDA-cleared LLM-based SaMDs, design controls under QMSR require artifacts such as audit logging for HIPAA compliance.
Physician Tip

UpDoc is designed to extend your clinical reach for chronic disease management, particularly for conditions like Type 2 diabetes. The AI agents can manage medication adjustments (e.g., insulin titration), facilitate lab orders, and coordinate with care teams within parameters you define. This can help proactively manage patients between visits, potentially reducing administrative burden and allowing you to focus on complex decision-making. Remember that while the AI provides patient-facing conversational support, the clinical decisions operate within your set limits, and the system is intended to complement, not replace, physician oversight.

UpDoc is built for seamless integration with Electronic Health Record (EHR) systems. It also integrates with remote patient monitoring devices. The company collaborates with major technology providers like Microsoft (leveraging GPT-4 through Azure Open AI Service) and Google Cloud (leveraging MedLM and fine-tuned models through Vertex AI) for its AI infrastructure. UpDoc also utilizes Jotform for data collection and workflows, and Stripe for payment processing, indicating a robust and flexible underlying technical architecture.

Details

Category Clinical Decision Support & Reference, Endocrinology & Metabolic AI, Patient Engagement & Education
Pricing Tiered subscription
DeploymentSaaS, EHR and workflow integrated.
Mobile AppYes, available for iOS.
Compliance
BAA AvailableUnknown
HIPAA Compliant Yes AI-estimated
FDA Status Cleared AI-estimated
SOC 2 Yes AI-estimated
GDPR Yes AI-estimated
Integrations
EHR Not specified
Specialties Cardiology, Endocrinology, Nephrology, Primary Care

What the Web Says

UpDoc Inc. (updoc.com) generally receives mixed reviews. Many users praise its convenience, speed, and accessibility for telehealth services like obtaining medical certificates, prescriptions, and referrals from home. However, a significant number of users express frustration with billing clarity, subscription management, and unresponsive customer support. Some physicians also have negative opinions, citing concerns about low pay for doctors and the company's business practices.

Overall: Mixed

Strengths

  • Convenient and accessible telehealth services from home.
  • Quick access to medical certificates, prescriptions, and referrals.
  • Fast callback times and efficient service delivery from practitioners.
  • User-friendly interface and streamlined process.
  • Ability to avoid waiting rooms and travel to a doctor's office.
  • Doctors are often described as professional, empathetic, and knowledgeable.

Limitations

  • Lack of clarity in billing and issues with subscription management.
  • Difficulties with customer support responsiveness and inability to reach a human directly.
  • Reports of unexpected charges and difficulty canceling subscriptions.
  • Concerns from physicians about low compensation and predatory business practices.
  • Potential for delays in receiving prescriptions or certificates.
  • Contracts automatically renewing without an 'out' and inability to buy out contracts.

Based on reviews from: ProductReview.com.au, App Store, MediCompare, Reddit, Trustpilot, Capterra, G2, PR Newswire

Last updated: 2026-08-26

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Press & Coverage

PR Newswire
UpDoc Debuts First FDA-Cleared Clinical AI Platform Built for Real-Time Patient Care Delivery and Intelligent Care Coordination
UpDoc announced FDA clearance for the first Software as a Medical Device (SaMD) that utilizes patient-facing large language models, alongside securing $18 million in seed financing and initiating deployments at four leading health systems.
2026-06
One-Stop Shop
A Pathway for Clinical AI Developers Opens: FDA Clears First Software as a Medical Device With Patient-Facing LLM
UpDoc Inc. received FDA clearance on June 25, 2026, for its Software as a Medical Device (SaMD) that incorporates patient-facing large language models, establishing a new regulatory pathway for clinical AI.
2026-07
IntuitionLabs
FDA Clears First LLM as a Medical Device: Inside UpDoc's 510(k)
UpDoc Inc. secured FDA clearance on December 23, 2025, for its type 2 diabetes management software, which utilizes patient-facing large language models for insulin management, and publicly announced it on June 25, 2026, alongside an $18 million seed funding round.
2026-07
Pittsburgh Post-Gazette
Clinical AI: Pittsburgh pilot will take on challenges of diabetes care
Allegheny Health Network is partnering with UpDoc Inc. to pilot an AI-powered platform for chronic disease management, specifically for type 2 diabetes, aiming to improve medication adherence and patient outcomes through remote intervention.
2026-07
unknown
UpDoc Debuts First FDA-Cleared Patient-Facing Clinical LLM for Insulin Management
UpDoc has introduced the first FDA-cleared agentic clinical AI platform with patient-facing large language models for insulin management in adults with type 2 diabetes, cleared on December 23, 2025.
2026-07
Digital Health Wire
UpDoc Lands First FDA Clearance for Patient-Facing AI - Digital Health Wire
UpDoc achieved the first FDA clearance for a patient-facing AI model, designed to support patients with type 2 diabetes by adjusting insulin doses within clinician-set parameters between visits.
2026-07
American Diabetes Association
The American Diabetes Association's Innovation Fund Invests in UpDoc to Accelerate the Future of AI-Driven Chronic Disease Management and Prevention
The American Diabetes Association's Innovation Fund has strategically invested in UpDoc, an AI company focused on physician-grade agentic AI for chronic disease management, to accelerate its mission to deliver AI-powered interventions for diabetes and related conditions.
2026-06
2 Minute Medicine
UpDoc Receives the First FDA Clearance for a Patient-Facing Large Language Model in Clinical Care
UpDoc received FDA clearance on June 25, 2026, for the first patient-facing large language model cleared as a Software as a Medical Device, establishing a new regulatory category for AI that directly interacts with patients outside of physician workflows.
2026-07

Videos

Product demos, reviews, and walkthroughs for UpDoc Inc..

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Frequently Asked Questions

UpDoc Inc.'s CDS system is designed for seamless integration with most major EHR platforms through standard APIs. It provides real-time alerts and recommendations directly within your patient charts, aiming to minimize disruption to your current clinical workflow.
UpDoc Inc.'s recommendations are evidence-based, drawing from a continuously updated database of clinical guidelines, peer-reviewed literature, and expert consensus. Our system tracks compliance rates and outcomes, which are regularly audited and can be provided to demonstrate effectiveness and adherence to best practices.
UpDoc Inc. offers flexible pricing models, including subscription-based tiers that vary depending on the size of your practice or institution and the specific modules you require. We have tailored solutions for individual physicians, small clinics, and large hospital networks, with detailed quotes available upon request after an initial needs assessment.
While UpDoc Inc.'s CDS is comprehensive, it is a supportive tool and not a substitute for clinical judgment. For complex or rare cases, the system provides access to a broader knowledge base and can highlight potential differential diagnoses, but it ultimately relies on the physician's expertise to interpret and apply the information.
UpDoc Inc. adheres to strict data privacy and security protocols, including HIPAA compliance and robust encryption methods, to protect sensitive patient information. Our system is designed with privacy by design principles, ensuring that patient data is anonymized and secured throughout its lifecycle.
Several CDS alternatives exist, each with varying features and specializations. UpDoc Inc. differentiates itself through its highly customizable alert system, its focus on integrating with a wide range of EHRs, and its commitment to continuously updating its evidence base with the latest clinical research and guidelines.
Yes, UpDoc Inc.'s CDS is highly customizable. It allows for the integration of specific institutional protocols, local formularies, and individual physician preferences to tailor the recommendations and alerts to your practice's unique needs and workflows.

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Suggest an Edit → | Report an issue | Last Verified: 2026-08-23 | First Added: 2026-08-23

Investors who backed UpDoc Inc.

Funded through the company that built this tool.

Polaris Partners
VC T3
Boston, United States
Polaris Partners is a Boston-based, multi-stage investment firm with deep healthcare and life-sciences expertise, having backed category-leading therapeutics, devices, diagnostics and digital…
AI/ML in Healthcare Biotech
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