OpenEvidence
About OpenEvidence
OpenEvidence is an American artificial intelligence company dedicated to transforming how physicians access and utilize medical knowledge for clinical decision support. The company provides an AI-powered medical search engine and an AI copilot that synthesizes real-time, citation-linked answers exclusively from a vast database of peer-reviewed medical literature, including content from prestigious journals like The New England Journal of Medicine and JAMA. This platform is designed to combat the overwhelming volume of new medical research, which doubles every five years, enabling clinicians to make faster, more evidence-based decisions at the point of care.
OpenEvidence’s mission is to organize and expand global medical knowledge, making it useful, accessible, and understandable for healthcare professionals. The platform is offered free of charge to verified U.S. clinicians and has achieved rapid adoption, being used by a significant percentage of physicians across more than 10,000 hospitals and medical centers nationwide. Beyond its core search capabilities, OpenEvidence is expanding into workflow modules for tasks such as order-set recommendations and discharge summary drafting.
The company emphasizes accuracy and transparency, ensuring that all responses are grounded in verifiable research and providing direct citations. OpenEvidence has established strategic content licensing partnerships with numerous medical organizations and journals, including the American Medical Association, the National Comprehensive Cancer Network (NCCN), and Cochrane Systematic Reviews, further deepening its evidence base.
Focus Areas
Business Intelligence
| Key Investors | Sequoia Capital, Google Ventures (GV), Nvidia, Blackstone, Thrive Capital, Kleiner Perkins, Craft Ventures, Mayo Clinic, DST Global, Coatue, Conviction, ICONIQ, Greycroft, Breyer Capital, BOND, Goanna, Meritech, Alkeon, Henry Kravis |
| Partnerships | The New England Journal of Medicine (NEJM), JAMA and the JAMA Network specialty journals, National Comprehensive Cancer Network (NCCN), Cochrane Systematic Reviews, American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF), American Medical Association (AMA), ACC, ADA, AAFP, NORD, AAOS, ACEP, GINA, SSO, ASAM, Wiley |
| Acquisitions | Amaro Analytics (acquired) |
| Technology | AI-powered platform, specialized AI models, multi-AI agentic architecture, multimodal and multicloud, trained exclusively on trusted peer-reviewed medical literature, HIPAA compliant, SOC 2 Type II certified |
What Physicians Need to Know
OpenEvidence is an invaluable tool for physicians seeking to save time and enhance clinical decision-making. Leverage its AI-powered search for quick, evidence-based answers at the point of care, reducing the need to sift through extensive literature. Utilize 'Visits' for efficient patient encounter transcription and automated note generation, enriched with the latest clinical guidelines. The 'Doctor Dialer' ensures HIPAA-compliant patient communication while protecting personal privacy. Furthermore, 'Coding Intelligence' can significantly reduce administrative burden by automating medical coding and optimizing reimbursement. The platform's commitment to transparent sourcing and peer-reviewed content helps build confidence in its recommendations, acting as a reliable 'AI copilot' rather than a replacement for clinical judgment.
OpenEvidence is actively working on integrations, with a notable collaboration with Sutter Health to launch the platform within Epic's electronic health record (EHR) workflows. This indicates a strategic direction towards seamless integration with existing clinical systems to further embed its AI-powered insights directly into physician workflows. The 'Doctor Dialer' and 'Visits' features are designed to unify communication, decision support, and documentation, reducing reliance on fragmented tools.
What the Web Says
OpenEvidence is an AI-powered medical search engine and clinical decision support platform designed to provide fast, cited answers to clinical questions from peer-reviewed medical literature. It has gained significant traction, with reports indicating that over half of all U.S. physicians are regular users. The platform is marketed as free for healthcare professionals, though its registration process is primarily geared towards the US market, often requiring an NPI number for verification. The company has achieved a high valuation and is actively integrating its tool into electronic health record systems of major health organizations.
Overall: PositiveStrengths
- Provides fast, cited answers to clinical questions grounded in peer-reviewed literature, reducing the risk of 'hallucination' compared to general LLMs.
- Offers inline citations that link to abstracts or national guidance, allowing users to verify information.
- Useful for quick reviews of rare diseases, finding specific epidemiology from papers, and generating discharge instructions.
- Includes features like an AI scribe for clinical documentation, drafting prior-authorization letters, patient handouts, and transcribing encounters.
- Has strong content partnerships with high-quality journals and organizations like NEJM, JAMA, NCCN, and Cochrane.
- Mobile application is highly rated and provides immediate recall of information, making it convenient for point-of-care use.
Limitations
- Relies heavily on academic literature, which can be less useful for practical management questions requiring guidelines rather than trial data.
- Can sometimes inaccurately summarize studies or draw wrong conclusions, requiring users to verify information by reading the original sources.
- Does not currently offer differential diagnosis generation or drug dosing tools, limiting its functionality for some bedside tasks.
- The 'free' model is ad-supported, with pharmaceutical advertising appearing alongside clinical results.
- Some users have reported issues with bias, where the AI tends to favor certain journals even if less relevant to the specific query.
- Access for UK clinicians can be challenging due to the US-centric registration process.
Based on reviews from: iatroX, Clinical AI Report, App Store - Apple, Elion, YouTube (SpeakMD w/Dr. Ajay Balaram,MD), Reddit (r/emergencymedicine), Reddit (r/FamilyMedicine), Reddit (r/InternalMedicine), PMC - NIH, Trustpilot, Heidi, Reddit (r/Residency), G2, Reddit (r/medicine), YouTube (Bloomberg Television and Markets), OpenEvidence, AI Heal Genius, Becker's Hospital Review | Healthcare News & Analysis, Fierce Healthcare, Reddit (r/careeradvice), HLTH, AAP News | American Academy of Pediatrics
Last updated: 2026-07-18
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Comparisons
When choosing between OpenEvidence and Doximity Ask, physicians should consider their primary need for AI-powered support. OpenEvidence excels as a comprehensive clinical decision support platform, providing immediate, referenced answers directly from a wide array of peer-reviewed medical literature and official guidelines. Its strength lies in its direct integration with major medical journals and organizations, ensuring […]
When considering AI tools for clinical practice, physicians can choose between OpenEvidence and Kahun, each offering distinct strengths. OpenEvidence excels as a comprehensive knowledge platform, providing immediate, referenced answers to clinical queries directly from peer-reviewed literature like NEJM and JAMA. It also integrates clinical documentation tools, allowing for transcription of patient visits and auto-generation of […]
When considering AI tools for clinical practice, physicians can evaluate OpenEvidence and Coding Intelligence (OpenEvidence Visits) based on their primary functions and target use cases. Both platforms are developed by OpenEvidence, are free for verified U.S. healthcare professionals, and are HIPAA compliant with BAA agreements, operating as cloud-based solutions. OpenEvidence excels as a comprehensive clinical […]
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