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Us2.ai
Us2.ai
Cardiology AI
Us2.ai is an FDA-cleared AI software that automates echocardiogram analysis, generating structured reports and detecting cardiac conditions like amyloidosis for clinicians, significantly reducing manual effort and improving diagnostic efficiency.

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About Us2.ai

Us2.ai is a leading healthcare AI company dedicated to democratizing expert-level cardiac diagnostics through advanced artificial intelligence solutions. For physicians, their FDA-cleared platform automates the comprehensive analysis of echocardiograms, transforming raw 2D and Doppler images into complete, structured reports in minutes. This includes automated measurements, disease detection, and clinical findings for every chamber of the heart, significantly reducing the manual effort and time traditionally required for echo interpretation.

The company’s technology is designed to integrate seamlessly into clinical workflows, connecting to ultrasound devices and PACS to process echocardiograms in real-time. This full automation, unlike semi-automated tools, eliminates the need for manual frame selection or limited measurements, providing fully explainable AI outcomes with editable annotations. Us2.ai’s solutions are clinically validated and aim to improve diagnostic accuracy, enhance efficiency in clinical trials for pharmaceutical companies, and support the timely detection of often-missed or hard-to-diagnose cardiovascular conditions, ultimately improving patient outcomes and expanding access to high-quality cardiac assessment globally.

Us2.ai’s software has demonstrated a significant reduction in measurement and report creation time compared to manual methods, as published in the Journal of Echocardiography. Their platform is trusted by leading institutions worldwide and is FDA cleared, CE Marked, and SOC 2 Type II certified, ensuring reliability and compliance in various healthcare settings.

Focus Areas

Echocardiography analysis AI cardiovascular disease detection heart failure pulmonary hypertension cardiac amyloidosis aortic stenosis strain imaging deep learning medical imaging biomarkers

Business Intelligence

Key InvestorsIHH Healthcare, Heal Partners, Sequoia Capital (now Peak XV Partners), EDBI, Pappas Capital, SGInnovate, Partech Ventures, Bfa Global Investors, East Post Road Ventures, FJ Labs
PartnershipsAstraZeneca (research), Janssen (research), Duke University, Fujifilm (OEM integration), deepc, Harrison.ai, Merative Merge, Brigham and Women's Hospital (validation study), Lenus Health, Alnylam, Viz.ai
TechnologyCloud-native, deep learning, AI-powered echocardiography analysis, fully automated, integrates with ultrasound devices and PACS, delivers structured reports, real-time processing, explainable AI output
FDA Clearances2 cleared products (estimated)

What Physicians Need to Know

Echocardiography Analysis Automation
Us2.ai specializes in fully automating the interpretation and analysis of echocardiograms, eliminating manual frame selection, annotation, and view selection. It processes both 2D and Doppler views to deliver comprehensive cardiac measurements and structured reports in seconds.
Cardiovascular Disease Detection
The platform facilitates the detection of a wide array of heart-related conditions, including heart failure (HFpEF, HFmrEF, HFrEF), pulmonary hypertension, cardiac amyloidosis, aortic stenosis, hypertrophic cardiomyopathy, valvular disease, and ischemic heart disease.
Advanced AI & Deep Learning
Us2.ai leverages advanced AI and deep learning algorithms for automated analysis, pattern recognition, and precise measurements. It's the first platform to combine deep learning pattern recognition with guideline-based echocardiographic measurements for automated detection of conditions like cardiac amyloidosis.
Strain Imaging & Biomarkers
The software offers comprehensive analysis, including Global Longitudinal Strain (GLS) and regional strain imaging, which are critical for nuanced diagnosis of heart failure and coronary artery disease. It provides over 45-150+ automated echocardiography measurements.
Regulatory Clearances
Us2.ai's solution is FDA-cleared and CE-marked, with clearances in over 30 countries, ensuring its clinical validation and trustworthiness in diverse healthcare settings.
Physician Tip

Us2.ai stands out for physicians by dramatically reducing the time spent on echocardiogram analysis and reporting (up to a 70% reduction), allowing more focus on patient interaction and complex cases. Its 100% AI automation delivers consistent, accurate, and guideline-directed reports with explainable AI outputs and editable annotations, boosting diagnostic confidence and reproducibility across studies and institutions. The platform's ability to detect often under-diagnosed conditions like cardiac amyloidosis from a single view, combined with comprehensive measurements and disease indications, supports earlier and more precise treatment decisions. Furthermore, its vendor-neutral and seamless integration capabilities streamline workflow, address sonographer shortages, and enable scalability for higher patient volumes without compromising quality.

Us2.ai is designed for seamless integration into existing clinical workflows. It connects directly to standard ultrasound devices via Us2.connect and is compatible with PACS for enterprise-wide storage. The platform has established partnerships with major cardiovascular imaging and AI solution providers, including Merative's Merge Cardio, Fujifilm's LISENDO 880 ultrasound system, Aidoc's aiOS, deepcOS, Ascend Cardiovascular, and TeraRecon's Eureka Clinical AI Platform, allowing for consolidated management of AI interpretation solutions and potential integration with EHRs for a holistic patient view.

Products by Us2.ai

1 product in the directory

Us2.ai
Us2.ai
Cardiology AI
Us2.ai is an FDA-cleared AI software that automates echocardiogram analysis, generating structured reports and detecting cardiac conditions like amyloidosis for clinicians, significantly reducing manual effort and improving diagnostic efficiency.

What the Web Says

Us2.ai is an AI-driven echocardiography reporting software that automates the analysis of cardiac ultrasounds, aiming to improve efficiency and accuracy in diagnosing heart conditions. It provides fully automated measurements and disease detection, delivering structured reports in seconds. The platform is FDA-cleared and CE marked, integrating with existing hospital infrastructure.

Overall: Positive

Strengths

  • Significantly reduces diagnosis and reporting time (by 10-20 minutes or 33% per study).
  • Enhances measurement accuracy and consistency, reducing variability between sonographers.
  • Aids in early detection of conditions like cardiac amyloidosis through AI-based pattern recognition.
  • Zero-click analysis and real-time processing streamline workflow.
  • Integrates with various ultrasound devices, PACS, CVIS, and EMR systems.
  • Preserves clinical autonomy by allowing sonographers and cardiologists to review and edit AI-generated measurements.

Limitations

  • Initial technical challenges with integration into existing systems were reported, though these have since been resolved with updates.
  • Some sonographers initially expressed concerns about AI potentially replacing their roles.
  • Trust in AI from physicians and sonographers needed to be built through validation and comparison with manual measurements.
  • Limited public reviews on platforms like G2, Glassdoor, and Capterra make it difficult to gather a wide range of independent user opinions.
  • Reddit discussions primarily focus on the general impact of AI in cardiac sonography rather than specific Us2.ai product reviews.

Based on reviews from: Us2.ai Testimonials, Us2.ai: AI Echocardiography Reporting Software, FDA-Cleared, User Perceptions of AI Echo | Us2.ai, How to Evaluate AI Echocardiography Platforms - Us2.ai, Top 10 Us2.ai Alternatives & Competitors in 2026 - G2, Compare EchoPAC vs. Us2.ai in 2026 - Slashdot, Compare Ultromics vs. Us2.ai in 2026 - Slashdot, AI-driven tools into echocardiography practice : r/cardiacsonography - Reddit, AI proved superior in assessing and diagnosing cardiac function when compared with echocardiogram assessments made by sonographers : r/science - Reddit, AI Echo in Clinical Workflow | Us2.ai, Capterra Pros and Cons | User Likes & Dislikes - G2, Best Artificial Intelligence Software: User Reviews from July 2026 - G2, Working at USAI: Employee Reviews | Indeed.com, G2 AI Reviews (Voice and Chat): We Tested Them, Here's the Verdict - Blastra, Capterra Reviews 2026: Details, Pricing, & Features | G2, Capterra: Find The Right Software, G2: Business Software and Services Reviews, Open Positions - Microsoft Research, MassMutual: A Life Insurance & Financial Services Company, IHG Careers | Hotel Jobs & Hospitality Careers, Glass Onion: A Knives Out Mystery - Wikipedia, Working at Ai2: Employee Reviews | Indeed.com, Top 8 Claude Skills for UI/UX Engineers - Snyk, Real-Time Jobsite Management Software | Fieldwire by Hilti | Fieldwire by Hilti, Gravador de tela gru00e1tis da Bandicam - O Melhor Programa de Captura de Tela, Vu00eddeos e Jogos

Last updated: 2026-07-22

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Press & Coverage

Us2.ai
Canon Medical Systems USA and Us2.ai Announce Reseller Relationship for AI-Enabled Echocardiography
Canon Medical Systems USA and Us2.ai have partnered, allowing Canon to offer Us2.ai's cloud-based AI echocardiography software alongside its Aplio i-series ultrasound systems. This collaboration aims to integrate AI into clinical workflows for cardiac imaging.
2026-07
Us2.ai
Us2.ai receives FDA clearance for Us2.v2, transforming cardiovascular ultrasound analysis
Us2.ai received FDA clearance for Us2.v2, an advanced image post-processing analysis software featuring 45 automated echo parameters, including strain analysis. This clearance is a significant step in advancing cardiovascular care through innovative technology.
2024-04
AuntMinnie
Us2.ai nabs $15M in funding round
Us2.ai secured $15 million in a Series A funding round to expand the commercial development of its automated echocardiography report software. The funds will support growth targets for clinical implementation in the U.S., Europe, and Asia, and expand commercial activities with pharmaceutical companies, research labs, and imaging providers.
2022-04
Us2.ai
Us2.ai receives CE mark for the latest version of its AI echo software
Us2.ai's latest version of fully automated echocardiography software received CE Mark clearance, expanding its clinical deployment across Europe. The updated platform includes 68 CE-marked echo parameters and incorporates AI-based pattern recognition to detect cardiac amyloidosis.
2025-06
Fujifilm Healthcare Americas Corporation
Fujifilm Partners with Us2.ai to Provide AI-Automated Echocardiography Analysis for Cardiologists and Sonographers Across the Nation
Fujifilm Healthcare Americas Corporation and Us2.ai have partnered to integrate Us2.ai's AI-driven, automated clinical workflow solution with Fujifilm's LISENDO 800 cardiovascular ultrasound system. This aims to fully automate the analysis and reporting of echocardiograms, providing comprehensive cardiac measurements.
2025-03
Us2.ai (Circulation: Cardiovascular Imaging)
Integrating Clinical Data with AI Echocardiography for Improved Cardiac Amyloidosis Detection
Published in Circulation: Cardiovascular Imaging, this international multicenter study demonstrates that integrating clinical and laboratory data with the FDA-cleared Us2.Ca deep learning model significantly improves cardiac amyloidosis detection. It achieved 93% sensitivity and 90% accuracy while eliminating indeterminate classifications.
2026-06
Us2.ai
How Us2.ai and Merge Are Bringing AI Echo Directly Into Clinical Workflows
Us2.ai and Merge have partnered to embed Us2.ai's AI directly into the Merge platform, streamlining clinical workflows for echo technicians and cardiologists. This integration eliminates the need for separate logins or changes to existing processes.
2026-04
Us2.ai (International Journal of Cardiology)
AI Echo for Post-AMI Risk Stratification: Predicting Outcomes After A Heart Attack
This study, published in the International Journal of Cardiology, involved 1,001 AMI patients and showed that combining AI-derived echocardiographic parameters with traditional clinical risk factors significantly improves the prediction of one-year mortality and major adverse cardiac events.
2026-06

Frequently Asked Questions

Us2.ai's technology seamlessly integrates with existing echocardiography workflows by connecting to ultrasound devices and PACS, processing echocardiograms in real-time, and delivering standardized, clinician-ready reports. It aids in the detection and quantification of various cardiovascular conditions including heart failure, pulmonary hypertension, cardiac amyloidosis, aortic stenosis, and provides comprehensive cardiac measurements like LV systolic and diastolic function and strain imaging.
Us2.ai has secured FDA 510(k) clearance for its automated echocardiography analysis, including strain imaging and cardiac amyloidosis detection, and holds CE Mark (Class IIb) for its comprehensive platform across Europe. The company ensures data privacy and compliance through adherence to HIPAA and GDPR, maintaining ISO 27001:2022 and SOC 2 Type II certifications, and implementing AES-256 encryption for data at rest and TLS 1.2+ in transit.
Yes, Us2.ai's platform provides fully automated global longitudinal strain (GLS) and regional strain measurements, with studies demonstrating accuracy comparable to conventional methods and the potential to democratize strain imaging. Its deep learning approach combines pattern recognition with guideline-based measurements to enhance diagnostic accuracy for complex conditions like cardiac amyloidosis, offering comprehensive, standardized, and reproducible analyses that reduce variability and improve efficiency.
Us2.ai operates on a volume-based pricing model, with specific installation and associated costs varying by the chosen configuration, requiring direct contact for a formal quotation. The company offers robust technical support for deployment, including cloud or on-premise options and integration with existing PACS, CVIS, or EMR systems, alongside providing training through its intuitive, guideline-directed reporting and editable AI outputs designed for various healthcare professionals.
Us2.ai has established partnerships with hardware and pharmaceutical companies (e.g., EchoNous, AstraZeneca), leading research institutions (e.g., University of Dundee, Stanford University), and other AI platforms (e.g., deepc, Harrison.ai). The company's long-term vision is to democratize expert-level cardiac diagnostics globally, supported by significant Series A funding from investors like IHH Healthcare and Sequoia India, underscoring its financial stability and commitment to expanding clinical adoption and alliances.
Us2.ai rigorously addresses concerns about clinical validation by emphasizing its extensive peer-reviewed evidence and multi-center international studies, demonstrating accuracy comparable to expert core lab readers for various measurements. To mitigate potential biases, the platform provides fully explainable AI outcomes and allows clinicians to directly edit annotations from the report, ensuring human oversight and control over AI-generated medical imaging biomarkers.
For heart failure, Us2.ai's AI automates the entire echocardiographic assessment, providing critical parameters like LVEF, GLS, diastolic function, and a full structural assessment in line with international guidelines, and can identify missed cases from EHRs for earlier intervention. In pulmonary hypertension, it offers the first validated fully automated right heart analysis, delivering all guideline-recommended parameters such as Peak Tricuspid Regurgitation Velocity (TRV), TAPSE, and Right Atrial Area, crucial for early detection and risk stratification.

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