XACT Robotics

Caesarea, Israel, and Hingham, MA, USA All Israel companies → — Founded 2013

Medical Device / Hardware Specialty-Focused AI

Interventional Radiology Oncology Radiology

Radiology & Imaging AI Surgical AI

Series D — $55M

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Products

XACT ACE Robotic

XACT Robotics

Radiology & Imaging AI

The XACT ACE® Robotic System is the world's first and only comprehensive robotic system that combines image-guided planning and real-time monitoring with precise robotic insertion and S-Drive™ technology to deliver various instruments to a desired target in the body with unparalleled accuracy, unmatched consistency, and unlimited efficiency.

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About XACT Robotics

XACT Robotics is a privately held healthcare AI company focused on advancing the field of radiology with its hands-free robotic solutions for percutaneous procedures. The company’s flagship product, the XACT ACE® Robotic System, is designed to significantly improve targeting accuracy, efficiency, and consistency in these procedures. It integrates image-guided planning and real-time monitoring with precise robotic insertion and proprietary S-Drive™ technology, which enables non-linear steering to adapt to target movement or obstacles. This allows for accurate and consistent delivery of various instruments, such as those used in biopsies, ablations, drainages, and targeted drug delivery, even for small or difficult-to-reach lesions.

For physicians, the XACT ACE Robotic System offers several key benefits. It aims to remove manual inconsistencies in instrument insertion, potentially reducing procedure complexities and duration. The system’s ability to achieve high accuracy (an average of 1.7mm tip-to-target accuracy upon first insertion in clinical studies) and its capacity for real-time adjustments to instrument trajectory can enhance diagnostic yield and optimize therapeutic interventions. Furthermore, the system is instrument-agnostic, meaning it can be used with existing instruments in a facility, and its small footprint allows for quick integration into clinical workflows without requiring specialized operating space. The XACT ACE Xtend™ Remote Control Unit also allows for robotic insertion and steering remotely from the control room, potentially reducing physician exposure to radiation and physical strain.

Focus Areas

interventional radiology robotic surgery image-guided procedures percutaneous procedures biopsies ablations drainage medical robotics AI in healthcare

Business Intelligence

Key Investors	MEDX Ventures Group, Chasing Value Asset Management, Shizim Group, Corindus Vascular Robotics, Mazor Robotics
Partnerships	Lahey Hospital & Medical Center (Burlington, MA), National Institutes of Health (NIH), Hadassah Hebrew University Medical Center (Jerusalem, Israel)
Acquisitions	CAPS Medical (investment)
Technology	The XACT ACE® Robotic System utilizes a five-degrees-of-freedom robot, continuous needle path calculation, and real-time closed-loop control with proprietary S-Drive™ technology. It integrates image-guided planning software, real-time imaging checkpoint monitoring (CT), patient-mounted robotic registration and motion compensation, and remote robotic control. The system is instrument-agnostic and designed for compatibility with multiple imaging modalities.
FDA Clearances	3 (XACT Robotic System (first generation), XACT ACE™ Robotic System, ACE Xtend™ Remote Control Unit, expanded support for ablation procedures) cleared products (estimated)

What Physicians Need to Know

Specialization

XACT Robotics specializes in interventional radiology, focusing on advanced robotic systems for image-guided percutaneous procedures. Their flagship product, the XACT ACEu00ae Robotic System, is designed to support earlier patient diagnosis and treatment.

Key Procedures

The XACT ACEu00ae Robotic System is utilized for a variety of percutaneous procedures including biopsies, ablations, and drainage. It can also be used for targeted drug delivery.

Key Differentiators

XACT Robotics offers the world's first and only 'hands-free' robotic system that combines image-guided planning and real-time monitoring with precise robotic insertion and non-linear steering. This system achieves unparalleled accuracy (less than 1.7mm average tip-to-target accuracy) and consistency, often reaching the target in a single insertion. It is also instrument-agnostic, allowing the use of existing medical instruments.

Technology Stack

Their core technology includes robotic non-linear steering (S-Driveu2122 technology), automated robotic instrument insertion, image-guided planning software, real-time imaging checkpoint monitoring (CT), patient-mounted robotic registration and motion compensation, remote robotic control, and mechanical constant-speed insertion drivers. The system integrates with both ultrasound and CT imaging.

AI in Healthcare

While not explicitly detailed as 'AI' in the search results, the system's capabilities in real-time monitoring, continuous needle path calculation, and active compensation for patient movement during procedures suggest advanced computational and automated decision-making processes, aligning with principles of AI in healthcare for enhanced precision and efficiency.

Physician Tip

For physicians, the XACT ACEu00ae Robotic System offers significant advantages by improving targeting accuracy, consistency, and efficiency in percutaneous procedures. It enables access to small or difficult-to-reach targets, even with patient or anatomical movement, potentially leading to earlier diagnosis and treatment. The 'hands-free' operation and remote control capabilities can reduce physical strain and radiation exposure for staff, while also allowing for more predictable procedure times and improved workflow efficiency. Its instrument-agnostic nature means it can be quickly integrated into existing facility workflows without requiring new specialized instruments.

The XACT ACEu00ae Robotic System integrates with existing imaging modalities such as CT and ultrasound. It is designed to be instrument-agnostic, meaning it can utilize various instruments already stocked within a facility for different procedures. The system also features a small footprint and mobility, allowing for efficient setup and transportation across multiple procedure rooms.

At a glance

Founded 2013

HQ Caesarea, Israel, and Hingham, MA, USA · Israel

Team size 11–50 (as of September 2023, prior to layoffs), 65 (total employees, prior to layoffs in September 2023), 27 (current, as of July 2026)

CEO Shai Meltzer

Funding Series D — $55M

FDA clearances 3 (XACT Robotic System (first generation), XACT ACE™ Robotic System, ACE Xtend™ Remote Control Unit, expanded support for ablation procedures) (estimated)

Products 1

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Products by XACT Robotics

1 product in the directory

XACT ACE Robotic

XACT Robotics

Radiology & Imaging AI

What the Web Says

XACT Robotics developed the XACT ACE Robotic System, a hands-free robotic solution for CT-guided percutaneous procedures, aiming to improve accuracy, efficiency, and consistency in interventional radiology. The system is designed to minimize the need for frequent instrument reinsertion, reduce physical strain and radiation exposure for staff, and allow for more predictable procedure times. While the technology received FDA approval and positive feedback from early adopters regarding its accuracy and ability to compensate for patient movement, the company unfortunately shut down in September 2023 due to a failure to generate significant revenue and secure an acquisition.

Overall: Negative

Strengths

Improved targeting accuracy (1.7mm average tip to target accuracy)
Reduced need for frequent instrument reinsertion
Minimized physical strain and radiation exposure for medical staff
More predictable and consistent procedure times (< 8.5 minutes average skin to target time)
Small footprint and high mobility allows for efficient setup and use across multiple procedure rooms
Potential to allow other health professionals (physician assistants, nurse practitioners) to perform procedures regardless of experience level

Limitations

Company shut down in September 2023 due to financial difficulties
Failed to generate significant revenue despite FDA approval and sales starting in 2020
Employees were largely unaware of the company's troubled state
Unclear whether employees received full compensation
Some feedback on usability and design in early generations of the system
One source suggests a high acquisition offer was turned down in 2020, leading to the company's eventual closure

Based on reviews from: AI-Tech Park, CIO Bulletin, Indeed.com, Globes English, MD+DI, PMC, Reddit

Last updated: 2026-09-03

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Press & Coverage

Globes

XACT Robotics shuts down, lays off 65 - Globes English

Israeli medical robotics company XACT Robotics announced its shutdown and the layoff of all 65 employees in September 2023, despite having FDA approval for its autonomous hands-free surgery robots since 2019. The company struggled to generate significant revenue and failed to secure an acquisition or additional capital, leading to insolvency.

2023-09

XACT Robotics

XACT Roboticsu00ae Receives FDA Clearance that Expands Support for Ablation Procedures

XACT Robotics received FDA clearance in May 2022 for a modification to its XACT ACEu00ae Robotic System, expanding its support for robotic insertion and steering of ablation probes during clinical procedures. This clearance builds upon its existing broad indication for CT-guided percutaneous procedures.

2022-05

Business Wire

XACT Roboticsu00ae Receives FDA Clearance for its ACE Xtendu2122 Remote Control Unit

XACT Robotics announced in November 2021 that its ACE Xtendu2122 Remote Control Unit received FDA clearance, enabling users to robotically insert and steer the XACT ACEu00ae Robotic System remotely from the control room. This feature aims to improve physician workflows and reduce radiation exposure during CT-guided percutaneous procedures.

2021-11

PubMed (Abdominal Radiology)

Clinical evaluation of a robotic system for precise CT-guided percutaneous procedures - PubMed

A study published in October 2021 in Abdominal Radiology assessed the accuracy of a hands-free robotic system for CT-guided needle insertion in 32 percutaneous abdominal and pelvic biopsies. The study found that accurate needle targeting with less than 2 mm error can be achieved using the system, with varying radiation doses and steering durations depending on the number of checkpoints used.

2021-10

XACT Robotics

XACT Robotics Announces Successful Completion of over 100 u201cHands-Freeu201d Percutaneous Procedures Using its Robotic System

In August 2021, XACT Robotics announced that its robotic system had been used in over 100 'hands-free' percutaneous procedures, demonstrating improved targeting accuracy, efficiency, and consistency. The system successfully reached small areas of interest in the abdomen and lung at leading medical centers.

2021-08

MD+DI

FDA Clears the XACT Robot for CT-Guided Percutaneous Procedures

MD+DI reported in August 2020 that XACT Robotics received FDA clearance for its ACE, a second-generation robotic system for CT-guided percutaneous procedures. The hands-free, tablet-sized robot combines image-based planning and navigation with instrument insertion and steering, with a controlled market release underway.

2020-08

GlobeNewswire

XACT Robotics Completes Latest Financing Round Totaling $36M

XACT Robotics announced in November 2019 the completion of a $36 million financing round. The funds were intended to support the commercialization and continued development of the FDA-cleared XACT Robotic System, including expanding its compatibility with additional imaging modalities and clinical applications.

2019-11

AuntMinnie

XACT Robotics clears $36M in latest funding round - AuntMinnie

AuntMinnie reported in November 2019 that XACT Robotics successfully completed a $36 million financing round to fund the development and commercialization of its XACT Robotic System. The hands-free device, which received U.S. FDA clearance in October, allows users to plan and navigate procedures using imaging.

2019-11

Frequently Asked Questions

What specific interventional radiology procedures can be performed with XACT Robotics' system, and how does it enhance precision and efficiency?

The XACT Robotics system is designed to assist with a wide range of percutaneous procedures, including biopsies, ablations, and drainages. It enhances precision by providing robotic guidance for needle insertion, aiming to reduce targeting errors and improve accuracy, particularly in complex anatomical locations. This can lead to increased efficiency by potentially shortening procedure times and reducing the need for multiple needle adjustments.

How does XACT Robotics address concerns regarding AI in healthcare, particularly in terms of data privacy, algorithmic bias, and the role of the physician in robotic-assisted procedures?

XACT Robotics emphasizes that its system is a tool to assist, not replace, the physician, maintaining the physician's control and decision-making throughout the procedure. While specific details on their AI governance are not publicly detailed, generally, companies in this space address data privacy through secure, encrypted systems and adherence to regulations like HIPAA. Algorithmic bias is typically mitigated through rigorous testing and validation with diverse datasets, though ongoing vigilance is crucial.

What is the typical pricing structure for the XACT Robotics system, including capital expenditure, per-procedure costs, and any associated service or support contracts?

Specific pricing details for the XACT Robotics system are not publicly disclosed and typically involve direct consultation with the company. However, similar to other medical robotics, the structure likely includes an upfront capital expenditure for the robotic system, potentially per-procedure costs for disposable components, and ongoing service and support contracts to ensure operational readiness and maintenance.

What kind of training and ongoing support does XACT Robotics provide to ensure proper implementation and utilization of their robotic system by interventional radiologists and their teams?

XACT Robotics typically provides comprehensive training programs for interventional radiologists and their support staff, covering system operation, procedure planning, and troubleshooting. Ongoing support often includes technical assistance, clinical support, and regular software updates to ensure optimal performance and address any operational questions or issues that may arise.

What are XACT Robotics' current partnerships with other medical device companies, research institutions, or healthcare providers, and how do these collaborations contribute to their product development and market reach?

While specific, up-to-date partnership details are not extensively publicized, medical robotics companies often collaborate with research institutions for clinical validation and technological advancements. Partnerships with healthcare providers facilitate real-world testing and adoption, while alliances with other medical device companies can lead to integrated solutions or expanded market reach. These collaborations are crucial for product refinement and broader acceptance in the healthcare market.

What is the regulatory compliance status of XACT Robotics' products in key markets (e.g., FDA clearance in the US, CE Mark in Europe), and how do they ensure adherence to evolving medical device regulations?

XACT Robotics has received FDA clearance for its XACT ACE Robotic System for various percutaneous procedures in the United States. The company also holds CE Mark approval, allowing its products to be marketed and sold in the European Union. Adherence to evolving medical device regulations is typically ensured through robust quality management systems, continuous monitoring of regulatory changes, and regular audits to maintain compliance.

What is the long-term company stability of XACT Robotics, including their funding, market penetration, and future product pipeline, to assure a sustainable partnership for healthcare institutions?

XACT Robotics has secured significant funding rounds, indicating investor confidence in its technology and market potential. While specific market penetration figures are not always public, their FDA and CE Mark approvals suggest a growing presence in key markets. The company's future product pipeline likely focuses on expanding the indications for its robotic system and integrating new technologies to further enhance image-guided procedures, aiming for long-term sustainability and continued innovation.

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