Impact Engine

VC Chicago, United States · Founded 2012

Impact Engine manages venture capital and private equity strategies that optimize both financial and social returns, focusing on economic opportunity, environmental sustainability, and health equity. Within health equity, the firm targets scalable, tech-enabled solutions that improve clinical outcomes and expand healthcare access for historically underserved populations.

About Impact Engine

Impact Engine is a Chicago-based impact venture firm that invests across education, economic empowerment, environmental sustainability, and health, with a thesis built around generating both financial returns and measurable social outcomes. The fund writes $250K to $2M checks at seed and Series A, typically as a co-investor rather than a lead, and reserves capital for follow-on. Healthcare exposure is partial and concentrated in digital health, behavioral health, and care delivery models that improve access for underserved populations, including Medicaid populations, rural communities, and low-income workers. AI focus is welcome where it improves access or reduces cost rather than as a standalone technology bet. Founders best suited are seed and Series A digital health CEOs with a clear impact thesis, ability to articulate measurable outcomes, and a market that includes underserved populations. Founders who do not fit include premium consumer wellness, therapeutics, devices, and digital health companies targeting only commercially-insured high-income populations. Geographic preference is US with a Midwestern and Chicago bias but no hard constraint. The entry path is warm introduction through a portfolio CEO, a Chicago-area operator, or an impact-investing co-investor at firms like Better Ventures or RH Capital. LinkedIn outreach to a partner with a focused impact-and-traction summary is a reasonable secondary option. Expect impact diligence including outcome metrics and beneficiary definitions alongside standard commercial questions, and an investor that values long-term mission alignment.

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Healthcare AI tools backed by Impact Engine

Tools made by companies in Impact Engine's portfolio that we cover in the directory.

Heidi Health
Heidi Health
Clinical Decision Support & Reference
Heidi Health is an AI medical scribe and care partner platform that automates clinical documentation, evidence search, and follow-up communication for clinicians, transcribing consultations in over 110 languages and integrating outputs into EHRs.
Heidi
Heidi Health
Clinical Decision Support & Reference
Heidi is an AI care partner that automates clinical documentation, evidence search, and follow-up communication, designed to save time, reduce administrative burden, and support better clinical decision-making for modern clinical practice.

Portfolio companies in our directory

Other portfolio companies

Companies in Impact Engine's portfolio not currently in our directory.

Team

Jessica Droste Yagan
Partner & Chief Executive Officer
LinkedIn
Priya Parrish
Partner & Chief Investment Officer
LinkedIn
Tasha Seitz
Partner
LinkedIn
Roger Liew
Partner
LinkedIn

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Last updated 2026-05-06. Sourced from this fund's published materials.
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