Hepatica v1

by Perspectum  · Based in United Kingdom → — Improving accuracy of liver health and volume assessment to support better pre-surgical decision making for patients with liver cancer.
General Surgery Oncology Radiology

Contact vendor for pricing details; service is reimbursed by cms and covered by many commercial payers.
Regulatory Status Disclosed

Overview

Hepatica v1 is a clinical and surgical decision support tool developed by Perspectum. It utilizes artificial intelligence to provide quantitative measurements and visualizations of liver health from magnetic resonance imaging (MRI) data.

The software is designed to assist clinicians in assessing a patient’s liver health, particularly for pre-surgical planning in liver cancer. It performs AI-driven delineation of the liver and individual Couinaud segments, generating a single report that includes quantitative metrics and images.

Hepatica v1 quantifies liver fibro-inflammation (cT1), fat (PDFF), and volume for both the whole liver and individual Couinaud segments. This information helps clinicians accurately predict future liver remnant (FLR) to inform surgical decision-making, identify patients at risk of poor post-operative outcomes, and potentially reduce post-surgical complication rates and hospital stays.

The tool integrates seamlessly into clinical workflows through a PACS-integrated cloud-based service and provides patient-friendly reports.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • AI-driven delineation of liver and Couinaud segments
  • Quantitative metrics for liver fibro-inflammation (cT1), fat (PDFF), and volume
  • 3D visualization and quantification of whole liver volume
  • Supports identification of patients at risk of poor post-operative outcomes
  • Clinically validated metrics for pre-operative liver health assessment
  • Patient-friendly reports
  • Seamless integration into workflow through a PACS-integrated cloud-based service
  • MRI-based, non-invasive, no radiation risk
  • Automatic liver segmentation and volumetry
  • Supports clinical estimation of Future Liver Remnant (FLR) volume

Use Cases

  • Pre-surgical decision making for patients with liver cancer
  • Assessment of overall liver health and volume
  • Risk stratification for post-operative outcomes in liver resection surgery
  • Identifying and characterizing undiagnosed background liver disease
  • Monitoring changes in liver health and volume (e.g., after DVE)
  • Supporting multidisciplinary teams and tumor boards in treatment planning

What Physicians Need to Know

Key Capabilities
Hepatica v1 uses AI-driven liver segmentation and quantitative multiparametric MRI to assess liver health. It quantifies regional liver volumes and biomarkers for scar tissue (fibro-inflammation via cT1), inflammation, and fat (PDFF) within individual Couinaud segments. This allows for 3D visualization and quantification of whole liver volume and health.
Clinical Utility
Hepatica v1 is a precision oncology decision support tool for liver cancer. It helps guide cancer treatment and tumor removal by providing pre-surgical assessment of liver health and volume. The tool can identify patients at higher risk of poor post-operative outcomes and longer hospital stays, aiding in surgical planning and potentially reducing complications.
Integration Options
Hepatica v1 seamlessly integrates into clinical workflows and provides reports via a PACS-integrated cloud-based service.
Compliance Status
Hepatica v1 has received 510(k) clearance from the U.S. Food and Drug Administration (FDA).
Pricing Model
Pricing information for Hepatica v1 is not publicly available.
User Experience
Hepatica v1 provides patient-friendly reports and is designed for seamless integration into the clinical workflow. It uses MRI, avoiding radiation risk for patients.
Implementation Complexity
Hepatica v1 is designed for seamless integration into existing clinical workflows through a cloud-based service.
Evidence Base
Clinical studies have demonstrated Hepatica v1's utility in identifying patients at risk of poor outcomes and longer hospital stays after liver resection surgery. It uses validated biomarkers like cT1 and PDFF, built on LiverMultiScan technology, which has an extensive evidence base.
Physician Tip

Hepatica v1 can be a valuable tool for pre-operative assessment in liver cancer patients, offering quantitative insights into liver health and volume. Pay close attention to the AI-driven segmentation and biomarker quantification (cT1 for fibro-inflammation and PDFF for fat) within individual Couinaud segments, as this can inform surgical planning and help predict post-operative risks. Integrating this information into multidisciplinary team discussions can lead to more informed decisions and potentially improved patient outcomes. The non-invasive nature (MRI-based) is also beneficial for patient safety.

Hepatica v1 is designed for seamless integration into existing clinical workflows, delivering patient-friendly reports via a PACS-integrated cloud-based service. This allows for efficient access to quantitative liver health assessments within the established imaging and reporting infrastructure of a healthcare facility.

Details

Category Oncology AI, Radiology & Imaging AI, Surgical AI
Pricing Contact vendor for pricing details; service is reimbursed by cms and covered by many commercial payers.
DeploymentCloud-based service, PACS-integrated
Compliance
BAA Available Yes AI-estimated
HIPAA Compliant Yes AI-estimated
FDA Status Cleared AI-estimated
Integrations
EHR Not specified
Specialties General Surgery, Oncology, Radiology

What the Web Says

Hepatica v1 by Perspectum is a post-processing medical device software designed to provide quantified metrics for assessing a patient's liver health. It utilizes MRI data to generate these metrics and is FDA-cleared. The software is part of a suite of AI tools aimed at streamlining liver health assessment in conjunction with other imaging technologies.

Overall: Positive

Strengths

  • Provides quantified metrics for liver health assessment
  • Utilizes MRI as its modality
  • FDA-cleared
  • Aids in streamlining liver health assessment
  • Supports review of MR data

Limitations

No significant limitations found in public reviews. Consider checking vendor documentation or requesting a demo for a thorough evaluation.

Based on reviews from: parikhradiology.com, scribd.com, nih.gov

Last updated: 2026-10-31

Ratings & Reviews

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Clinical Value
Ease of Use
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Support & Docs
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Press & Coverage

AuntMinnie.com
FDA clears Perspectum's liver cancer decision tool
The U.S. Food and Drug Administration (FDA) has cleared Perspectum's Hepatica surgical decision-support tool for liver cancer. Hepatica uses quantitative, multiparametric MRI data to provide a liver health assessment to aid clinicians in making informed presurgical decisions and improve postsurgery outcomes.
2021-01
fda.gov
Hepatica v1 (Hepatica v1.0.0) FDA 510(k) Premarket Notification
This document details the FDA 510(k) premarket notification for Hepatica v1 (Hepatica v1.0.0) by Perspectum, Ltd., indicating its regulatory clearance for use.
2021-01
perspectum.com
AI-driven clinical and surgical decision support tool for liver cancer
Hepatica is an AI-driven clinical and surgical decision support tool that provides quantitative measurements and visualizations of liver health from MRI data, primarily for pre-surgical planning in liver cancer. It has demonstrated utility in identifying patients at risk of poor outcomes and longer hospital stays after resection surgery.
unknown
perspectum.com
Quantitative liver function imaging and whole genome sequencing – Effective modalities for a new era in personalised decision-making for operable colorectal liver metastases?
This study, published in HPB in 2025, highlights how preoperative mpMRI, including Hepatica, and whole-genome sequencing (WGS) informed personalized surgery for operable colorectal liver metastases in the Precision1 trial. mpMRI frequently influenced surgical plans, demonstrating the utility of such tools in clinical decision-making.
2025
perspectum.com
Novel multimetric MRI detects improved future liver remnant quality post-dual vein embolization
Hepatica showed a significant improvement in future liver remnant (FLR) health, measured by cT1 and PDFF, in patients with liver metastasis and insufficient FLR after undergoing dual vein embolization in the Precision1 clinical trial. This suggests a significant advance in preventing liver failure in patients undergoing major liver surgery.
unknown
nih.gov
AI in Liver Cancer Management: Current Status and Future Directions
This article mentions Perspectum's Hepatica v1 as one of the AI tools used in CT and MRI to streamline processes for liver cancer management. It highlights the role of AI in improving liver anatomy depiction and segmentation.
2024-04
physicianaitools.com
Hepatica v1 by Perspectum
Hepatica v1 by Perspectum is described as an AI-driven clinical and surgical decision support tool that provides quantitative measurements and visualizations of liver health from MRI data, primarily for pre-surgical planning in liver cancer. It is noted to be reimbursed by CMS and covered by many commercial payers.
2026-04
perspectum.com
Hepatica v1.0 US – A Guide to Interpreting Liver Tissue Characterization (v2.0 CURRENT) [ENG]
This is a current product manual for Hepatica v1.0 in the US, providing a guide to interpreting liver tissue characterization. It is available for download from Perspectum's website.
unknown

Videos

Product demos, reviews, and walkthroughs for Hepatica v1.

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Frequently Asked Questions

Hepatica v1 is a precision oncology decision support tool for liver cancer, developed by Perspectum. It uses non-invasive quantitative multiparametric MRI to assess liver health and volume, aiding in pre-surgical planning and identifying patients at risk of poor post-operative outcomes.
Hepatica has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its use as a surgical decision-support tool for liver cancer.
While Hepatica v1 offers AI-driven multiparametric MRI for liver health assessment, other methods exist. Traditional biopsies are an invasive gold standard, but non-invasive imaging technologies like Perspectum's LiverMultiScan and CoverScan also provide quantitative metrics for liver health, fat, iron, and fibro-inflammation.
While Hepatica v1 offers significant advancements, the general limitations of AI in medicine include the need for high-quality, diverse data to avoid mistakes, and the ongoing development of many AI tools. Physicians still need to understand how AI makes its decisions, which isn't always easy. Specific limitations for Hepatica v1 are not explicitly detailed, but it is a decision support tool and not a replacement for clinical judgment.
Hepatica v1 is designed for seamless integration into the clinical workflow, providing patient-friendly reports via a cloud-based service. It uses AI to delineate liver volume and individual Couinaud segments, and the MRI-based approach means no radiation risk for patients.

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Suggest an Edit → | Report an issue | Last Verified: 2026-04-19 | First Added: 2026-04-19
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