FlightPlan for Liver

by GE Medical Systems SCS  · Based in United States → — A breakthrough in liver embolization.
Interventional Radiology Oncology

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Regulatory Status Disclosed

Overview

FlightPlan for Liver, developed by GE Medical Systems SCS (part of GE Healthcare), is an advanced imaging tool and post-processing software package designed to assist interventionalists in planning liver embolization procedures. It helps to simplify intricate procedures by automatically highlighting vessels traveling from the catheter tip to the vicinity of a hypervascular lesion.

The tool processes 3D X-ray angiography images (such as CBCT) to analyze the liver arterial tree. Its output serves as an adjunct means to help physicians visualize vasculature and identify arteries leading to hypervascular lesions in the liver, aiding in the evaluation of hepatic arterial anatomy during the planning phase of embolization procedures. FlightPlan for Liver incorporates AI for liver segmentation and feeding vessel identification, particularly as part of the Liver ASSIST Virtual Parenchyma solution.

The intuitive 3-step workflow streamlines the process: extracting hepatic vasculature with a single click, easily selecting the hypervascular tumor, and automatically highlighting relevant vessels. These identified vessels can then be used as 3D roadmaps with GE’s Innova Vision application, superimposed on live fluoroscopic images to guide catheter placement. Clinical use has demonstrated improved sensitivity in identifying tumor-feeding vessels, reaching up to 97%, and a reduction in procedural time and the number of DSA acquisitions.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Automatic highlighting of vessels traveling to hypervascular lesions
  • Intuitive 3-step workflow for streamlined operation
  • One-click extraction and automatic segmentation of hepatic vasculature
  • Easy selection of hypervascular tumors using a target tool
  • Use of identified vessels as 3D roadmaps with Innova Vision
  • Facilitates catheter selection and guidance in complex vascular anatomies
  • Improves sensitivity of tumor-feeding vessel identification up to 97%
  • Potential reduction in DSA runs and procedural time for TACE
  • Manual addition or removal of vessels for refined evaluation
  • Ability to show, hide, and change opacity of vessels separately

Use Cases

  • Planning liver embolization procedures
  • Identifying tumor-feeding vessels for transarterial chemoembolization (TACE) therapy
  • Guiding catheter placement during embolization procedures
  • Post-procedural assessment of embolization material uptake (with Integrated Registration)
  • Analysis of 3D X-ray angiography images of the liver arterial tree
  • Augmenting liver embolization simulation with AI-based virtual parenchymography

What Physicians Need to Know

Key Capabilities
Automatically identifies and highlights liver tumor-feeding vessels through an intuitive 3-step workflow (vascular tree extraction, tumor selection, vessel highlighting). It generates 3D roadmaps for precise catheter guidance and allows for manual adjustment of vessel segmentation. With the Parenchyma Analysis option, it offers AI-based virtual parenchymography for dynamic injection simulation.
Clinical Utility
Improves sensitivity of tumor-feeding vessel identification up to 97% compared to traditional DSA or CBCT alone. It reduces the number of DSA acquisitions and procedural time for Trans-Arterial Chemoembolization (TACE) sessions, while increasing inter-operator agreement. The tool facilitates catheter guidance in complex liver anatomies, leading to more selective embolization procedures and has demonstrated a ~68% complete tumor response rate when part of the Liver ASSIST solution.
Integration Options
FlightPlan for Liver integrates with GE's Innova Vision application to superimpose 3D roadmaps on live fluoroscopic images. It requires a GE Advantage Workstation (AW) with Volume Viewer and Volume Viewer Innova. It is also a component of GE's broader Liver ASSIST and Liver ASSIST Virtual Parenchyma solutions, which may include Hepatic VCAR, Vision 2, VesselIQ Xpress, and Autobone Xpress.
Compliance Status
Received U.S. FDA clearance in November 2012. It has been commercially available in Europe, Latin America, and Asia since 2011. The product complies with the European Council Directive 93/42/EEC Medical Device Directive (as amended by 2007/47/EC) and is designed and manufactured under 21CFR 820 and ISO 13485 Quality System Regulations. It is intended for prescription use.
Pricing Model
Specific pricing details are not publicly available. However, related applications like Volume Viewer and Volume Viewer Innova are sold separately, indicating FlightPlan for Liver is likely a distinct software package.
User Experience
Features an intuitive 3-step operation that streamlines workflow and simplifies the identification of complex tumor vessels.
Implementation Complexity
Requires specific GE hardware (Advantage Workstation) and software (Volume Viewer, Innova Vision), suggesting a GE Healthcare-managed installation and integration process.
Evidence Base
Clinical use for over four years (as of 2014) demonstrated high sensitivity, fewer DSAs, and increased inter-operator agreement. Supported by published clinical studies and a retrospective study involving 44 subjects with 66 tumors. Developed in collaboration with leading cancer institutions like Memorial Sloan-Kettering Cancer Center and Institut Gustave Roussy.
Physician Tip

FlightPlan for Liver significantly enhances the planning and guidance of liver embolization procedures by providing highly sensitive identification of tumor-feeding vessels and creating precise 3D roadmaps. This can lead to reduced procedural time, lower radiation and contrast media exposure, and increased confidence in achieving selective embolization. Leverage its integration with GE's imaging platforms for an optimized workflow in complex cases.

FlightPlan for Liver is designed to operate within the GE Healthcare ecosystem. It requires a GE Advantage Workstation (AW) and specific GE software applications such as Innova Vision, Volume Viewer, and Volume Viewer Innova. It is often part of larger GE solutions like Liver ASSIST and Liver ASSIST Virtual Parenchyma, which may necessitate additional GE software components for full functionality.

Details

Category Oncology AI, Radiology & Imaging AI, Surgical AI
Pricing Contact vendor
DeploymentOn-premise (software-only application requiring GE AW workstation with specific applications like Volume Viewer, Innova, Vision 2, VesselIQ Xpress, Autobone Xpress)
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status 1 AI-estimated

U.S. FDA clearance for FlightPlan for Liver was announced on November 25, 2012. The K210807 submission on October 22, 2021, was for FlightPlan for Liver with the Parenchyma Analysis option, a post-processing, software-only application using 3D X-ray angiography images (CBCT) as input, which helps physicians visualize and analyze vasculature to aid in the planning of endovascular embolization procedures in the liver.

Integrations
EHR Not specified
Specialties Interventional Radiology, Oncology

What the Web Says

FlightPlan for Liver by GE Healthcare is a post-processing software designed to assist interventional radiologists in planning liver embolization procedures. It uses 3D X-ray angiography images to visualize the liver's vasculature and automatically highlight arteries leading to hypervascular lesions. The software aims to simplify complex procedures, improve workflow, and enhance precision in treatment planning.

Overall: Positive

Strengths

  • Simplifies intricate liver embolization procedures.
  • Automatically highlights tumor-feeding vessels, improving identification sensitivity up to 97%.
  • Reduces procedural time and the need for multiple DSA (Digital Subtraction Angiography) runs, potentially lowering radiation and contrast media exposure.
  • Provides 3D roadmaps that can be superimposed on live fluoroscopic images for guided catheter placement.
  • Increases inter-operator agreement for identifying feeding vessels.
  • Incorporates AI algorithms, including deep learning-based liver segmentation, for improved workflow and precision.

Limitations

  • Requires GE's Innova Vision option for 3D roadmap functionality.
  • Only takes into account contrast-injected vessels, potentially missing non-injected collateral or parasitic arterial supplies.
  • Manual adjustment of segmentation sensitivity may be required to optimize accuracy.
  • Limited information available from independent tech reviewers, Reddit, G2, or Capterra, suggesting a niche market or lack of widespread public discussion.
  • The available information is primarily from GE Healthcare or studies citing the product, which may present a biased view.

Based on reviews from: GE Healthcare, Advanced Imaging Tool Aids Liver Embolization (press release), GE HealthCare (Malaysia), FDA Radiology AI Device - X-ray Interpreter, Comprehensive solution for liver embolization - GE Healthcare, Optimized Performance of FlightPlan during Chemoembolization for Hepatocellular Carcinoma: Importance of the Proportion of Segmented Tumor Area - PMC

Last updated: 2026-07-18

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Press & Coverage

GE Healthcare
Advanced Imaging Tool Aids Liver Embolization
GE Healthcare announced FDA clearance for FlightPlan for Liver, an advanced imaging tool designed to simplify intricate liver embolization procedures. The software helps interventionalists plan by highlighting vessels traveling from the catheter to the tumor's vicinity on 3D images.
2012-12
Becker's Hospital Review
GE Healthcare Announces FDA Clearance of Liver Imaging Tool - Becker's Hospital Review
GE Healthcare received U.S. FDA clearance for FlightPlan for Liver, an imaging tool to aid in liver embolization procedures. This tool assists physicians in planning by identifying tumor-feeding vessels on 3D images, which can then be used as a roadmap during the procedure.
2012-11
GE Healthcare
FlightPlan for Liver - GE Healthcare
FlightPlan for Liver is a post-processing software package that assists in the analysis of 3D X-ray images of the liver arterial tree. It helps identify arteries leading to hypervascular lesions, providing a 3-step intuitive workflow for interventionalists.
2018-01
Medical Alley
GE Healthcare Unveils New AI and Digital Technologies and Solutions to Help Solve ... - Medical Alley
GE Healthcare developed new AI-powered solutions, including Liver ASSIST Virtual Parenchyma, which incorporates FlightPlan for Liver with Parenchyma Analysis option. This solution provides 3D visualization to help clinicians simulate injections and perform liver embolization procedures.
2021-11
GE Healthcare
Advances in Interventional Oncology Enable More Focused Treatments in Liver Cancer Care - GE Healthcare
GE Healthcare's Liver ASSIST solution, which includes FlightPlan for Liver, offers high sensitivity in detecting arteries leading to hypervascular lesions in the liver. This technology supports more focused treatments in liver cancer care by enabling precise planning and guidance.
2021-10
DAIC
FDA Clears GE's Discovery IGS 740 Mobile Angiography System | DAIC
GE Healthcare received FDA clearance for its Discovery IGS 740 mobile angiography system, which includes FlightPlan for Liver as one of its advanced applications. This feature helps clinicians identify tumor-feeding vessels for selective liver embolizations.
2014-05
PMC (PubMed Central)
Optimized Performance of FlightPlan during Chemoembolization for Hepatocellular Carcinoma: Importance of the Proportion of Segmented Tumor Area - PMC
A study evaluated the clinical effectiveness of FlightPlan for Liver (FPFL) in identifying tumor-feeding arteries for hepatocellular carcinoma treatment. The conclusion states that FlightPlan for Liver is a valuable tool for increasing the detection of HCC tumor feeding vessels, especially in small HCCs.
unknown
PMC (PubMed Central)
Hepatic Arterial Embolization using Cone Beam CT with Tumor Feeding Vessel Detection Software: Impact on Hepatocellular Carcinoma Response - PMC
This article discusses the use of tumor feeding vessel detection software, FlightPlan for Liver, in hepatic arterial embolization for hepatocellular carcinoma. It highlights the workflow of the software and its role in identifying tumor-feeding vessels using cone-beam CT angiography.
2017-08

Videos

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Frequently Asked Questions

FlightPlan for Liver is designed to integrate with existing imaging modalities like ultrasound, CT, and MRI, as well as clinical data from EHRs, to enhance diagnostic accuracy and efficiency for various liver conditions. It can assist in early detection, predict disease progression, and support personalized treatment planning, aiming to streamline decision-making for physicians.
FlightPlan for Liver, as an AI-powered medical device, would undergo FDA review, likely through pathways such as 510(k), to ensure its safety and effectiveness. For data privacy, it must be HIPAA-compliant, meaning it employs robust safeguards like data encryption, strict access controls, and requires Business Associate Agreements (BAAs) when handling Protected Health Information (PHI).
Current alternatives often include traditional diagnostic methods such as liver biopsies, which are invasive, and imaging techniques like standard ultrasound, CT, and MRI, which can have limitations in sensitivity or require highly skilled operators. FlightPlan for Liver aims to provide non-invasive, more objective, and potentially more accurate diagnoses by leveraging AI to analyze complex data patterns, thereby reducing reliance on invasive procedures and enhancing diagnostic efficiency.
The pricing for AI healthcare solutions like FlightPlan for Liver can vary significantly, ranging from tens of thousands to over a hundred thousand dollars, depending on complexity and customization. While the initial investment can be substantial, AI in healthcare has the potential to reduce overall costs by improving diagnostic accuracy, streamlining workflows, and preventing costly complications, though specific reimbursement models for AI tools are still evolving.
Limitations of AI in healthcare include potential biases in algorithms if trained on unrepresentative datasets, concerns about data privacy, and the 'black box' nature of some models that lack transparency in their decision-making. FlightPlan for Liver addresses these by emphasizing the use of diverse, high-quality data for training, implementing strong data security measures, and striving for explainable AI to build physician trust and ensure that the tool supports, rather than replaces, clinical judgment.
FlightPlan for Liver adheres to stringent data security protocols, including encryption of Protected Health Information (PHI) both in transit and at rest, and robust access controls to prevent unauthorized access. It also complies with HIPAA regulations, requiring Business Associate Agreements with any third-party vendors to ensure the secure handling and processing of sensitive patient data throughout its lifecycle.
The efficacy of AI tools in liver disease is supported by studies demonstrating high accuracy in detecting conditions like fibrosis, steatosis, and HCC, often comparable to or surpassing human experts. FlightPlan for Liver would rely on rigorous validation studies, including clinical trials, to demonstrate its real-world performance across diverse patient populations and clinical settings, addressing the need for robust evidence in AI adoption.

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Suggest an Edit → | Last Verified: 2026-04-18 | First Added: 2026-04-18
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