Pearl Second Opinion®

by Pearl  · Based in United States → — Practice Better with Pearl. Our AI tools help dental practices deliver smarter, faster, more productive patient care.
Dentistry
Website
Claim this tool
Is this the maker? Claim the company →

Starting at $299.00 per month
Regulatory Status Disclosed

Overview

Pearl Second Opinion® is a leading dental AI tool designed to enhance diagnostic accuracy and streamline dental practice operations. It offers FDA-cleared artificial intelligence for both 2D and 3D dental X-ray analysis, assisting clinicians in the precise detection of various pathologies, including caries, calculus, bone loss, and periapical radiolucencies. By providing colorful radiologic findings, objective insights, and personal health reports, Pearl helps build patient confidence and can drive up to 30% more treatment acceptance.

Beyond diagnosis, Pearl’s suite of AI tools, including Practice Intelligence®, Precheck™, Calibrate®, Second Opinion 3D®, and Pearl Voice™, optimizes front desk workflows with features like smart scheduling, enhanced patient recall, and instant insurance verification, potentially saving office teams over 20 hours per week. It also improves revenue by identifying treatment opportunities and ensuring cleaner claim submissions, boosting monthly production by up to $30K per practice. Pearl integrates seamlessly with over 40 imaging and practice management systems, making it a comprehensive solution for dental professionals worldwide.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • AI-powered pathology detection (2D & 3D X-rays)
  • Real-time image analysis
  • Enhanced diagnostic accuracy (94% accuracy)
  • Patient-friendly visual reports and case presentation tools
  • Practice performance analytics (Practice Intelligenceu00ae)
  • Automated insurance verification and claims pre-submission (Prechecku2122)
  • AI-guided clinical training (Calibrateu00ae)
  • Ambient voice AI for clinical notes and perio charting (Pearl Voiceu2122)
  • Integration with imaging and practice management systems (40+ integrations)
  • Cloud-based access

Use Cases

  • Increase treatment acceptance (up to 30%)
  • Detect more disease (up to 37%)
  • Improve diagnostic consistency and confidence
  • Streamline front desk workflows and save staff time
  • Boost monthly production and revenue
  • Support clinical training and consistency across practices/DSOs

What Physicians Need to Know

Dental X-Ray Analysis
Pearl Second Opinionu00ae is an FDA-cleared AI system that provides real-time analysis of dental X-rays, acting as a 'second set of eyes' to highlight potential issues. It detects up to 18 dental findings, including caries, bone loss, calculus, periapical lesions, and restoration discrepancies.
Caries Detection Accuracy
The AI system demonstrates high accuracy in caries detection, with studies showing improved diagnostic accuracy from 82% to 98% when used by clinicians. It can detect early and interproximal decay with 94% accuracy, including subtle enamel demineralization and early dentinal involvement.
Periodontal Assessment
Pearl Second Opinionu00ae includes FDA-cleared automated bone level measurement (Second Opinionu00ae BLE) for bitewing and periapical radiographs, allowing precise visualization of mesial and distal bone levels. It identifies signs of gum disease and jawbone atrophy, with color-coded measurements indicating severity.
Treatment Planning AI
The AI analyzes X-rays to highlight pathologies, assisting dentists in building customized treatment plans. It provides detailed insights and recommendations, and its Second Opinion 3Du00ae feature supports precise diagnostics and planning across specialties like implantology and oral surgery.
Dental Imaging Integration (CBCT/Panoramic)
Pearl Second Opinionu00ae is FDA-cleared for both 2D radiographs (bitewing, periapical, panoramic) and 3D CBCT imaging. Second Opinion 3Du00ae transforms complex CBCT scans into clear, actionable 3D insights with automated segmentation of anatomical structures in under 40 seconds.
Practice Management Integration
Second Opinionu00ae is designed for seamless integration into existing dental workflows and is natively integrated with various imaging and practice management systems, including Carestream Dental's CS Imaging and Oryx Dental Software. It also integrates with Pearl's Practice Intelligence for broader analytics.
Patient Communication Tools
The system enhances patient understanding and trust through clear, color-coded AI highlights on X-rays, educational tooth part maps, and a comparison mode to illustrate disease progression. This visual evidence can boost treatment acceptance by up to 30%.
Insurance Pre-Authorization
Pearl offers 'Prechecku2122', an AI-powered tool for instant insurance eligibility and benefits verification. It automatically verifies insurance, pulls detailed coverage information (including tooth-specific histories), and identifies pre-authorization requirements to streamline claims and reduce errors.
Orthodontic Planning
Second Opinion 3Du00ae supports orthodontic planning by providing instant AI-powered visualizations and automated identification of critical anatomical structures in CBCT scans, aiding in more precise diagnostics and treatment planning across specialties.
Physician Tip

Pearl Second Opinionu00ae serves as a powerful diagnostic aid, enhancing accuracy and consistency in X-ray interpretation. Leverage its visual annotations and color-coding during patient consultations to foster understanding and increase treatment acceptance. Utilize the automated bone level measurements for standardized periodontal assessments. While the AI provides robust support, always exercise your clinical judgment for final diagnostic decisions and treatment plans. Integrate Pearl's Prechecku2122 for insurance verification to significantly reduce administrative burden and provide patients with transparent financial expectations upfront.

Pearl Second Opinionu00ae is engineered for seamless integration into existing dental practice workflows and imaging software, including native integrations with platforms like Carestream Dental's CS Imaging and Oryx Dental Software. It also complements Pearl's other AI solutions, such as Practice Intelligence and Prechecku2122, to offer a comprehensive suite of tools for clinical, operational, and administrative efficiency. Pearl is continuously working to expand its integration capabilities across a multitude of imaging software platforms.

Details

Category Dental AI, Radiology & Imaging AI
Pricing Starting at $299.00 per month
  • Starting at $299.00 per month (flat rate); custom pricing for larger practices; setup fees may apply (around $1,500, with promotions available)
DeploymentCloud-based, integrates with existing imaging and practice management systems.
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status 1 AI-estimated

Pearl is the first and only dental AI company with FDA-cleared solutions for both 2D and 3D dental radiologic image analysis, including detection of pathologies like caries, calculus, bone loss, and periapical radiolucencies, and automated identification of critical anatomical structures in 3D scans.
Integrations
EHR Not specified
Specialties Dentistry

What the Web Says

Pearl Second Opinionu00ae is an FDA-cleared AI software designed to assist dentists in detecting various dental pathologies from X-rays. It aims to enhance diagnostic accuracy and consistency, as well as improve patient communication and case acceptance. The software analyzes 2D radiographs in real-time, highlighting potential issues with color-coded overlays, and is expanding into 3D CBCT analysis.

Overall: Positive

Strengths

  • High diagnostic accuracy (94-95% for disease detection) validated by independent third parties.
  • Excellent patient communication tool due to visual, color-coded overlays that help patients understand diagnoses and increase case acceptance.
  • Detects a wide range of findings (up to 18 per image), including early-stage caries, bone loss, calculus, and periapical lesions.
  • FDA-cleared for both 2D and 3D imaging, making it a leader in dental AI.
  • Integrates with most major practice management and imaging systems.
  • Acts as a valuable 'second set of eyes' for dentists, catching things that might otherwise be missed and standardizing diagnostics across multiple providers.

Limitations

  • Can produce false positives and may miss some issues, requiring dentists to double-check findings.
  • Uploading X-rays can be a hassle for some users.
  • The AI is not always as well-trained as other systems, and the coloration for anatomical layers versus caries could be improved.
  • Customer support can be lacking and slow to respond.
  • Does not currently offer 3D diagnosis (though it is under development).
  • No published pricing, requiring a sales conversation for quotes, and can be a significant investment.

Based on reviews from: Reddit, G2, The Molar Report, Capterra, Dental Economics, Pearl AI Dental Software Reviews, FeaturedCustomers

Last updated: 2026-07-21

Ratings & Reviews

No reviews yet. Be the first to review this tool!

Rate Pearl Second Opinion®

Clinical Value
Ease of Use
Integration
Support & Docs
Value for Money

Press & Coverage

Pearl (via Google Search)
FDA Clears Pearl's Second Opinionu00ae for Automated Bone Level Analysis
Pearl received FDA 510(k) clearance for Second Opinionu00ae BLE, an advanced feature for automated bone level measurement in dental radiographs, making periodontal analysis faster and easier for dentists. This clearance expands Pearl's FDA-cleared AI portfolio, enhancing accurate periodontal assessment and treatment planning.
2026-07
Pearl (via Google Search)
Pearl Becomes First Dental AI Company Cleared by FDA for Both 2D and 3D Imaging
Pearl announced FDA 510(k) clearance for Second Opinionu00ae 3D, making it the first dental AI company with FDA-cleared solutions for both 2D and 3D dental radiologic image analysis. This extends AI capabilities to CBCT imaging for automated identification of critical anatomical structures, aiding in more precise diagnostics and treatment planning.
2025-05
Pearl (via Google Search)
Pearl Secures FDA Clearance for Pediatric AI in Dental Radiography
Pearl received FDA 510(k) clearance for Second Opinionu00ae Pediatric, allowing the platform to assist dentists in detecting caries for pediatric patients as young as 4 years old. This expands the clinical utility of Second Opinionu00ae, enabling earlier and more accurate detection of caries in younger patients.
2025-11
Dentistry Today
Pearl Expands Dental AI Capabilities with FDA Clearance for Panoramic X-Rays
Pearl received FDA 510(k) clearance for AI-powered detection of dental pathologies on panoramic radiographs, expanding its Second Opinionu00ae platform to identify suspected caries, periapical radiolucencies, and impacted third molars. This clearance strengthens Pearl's position as a comprehensive FDA-cleared radiologic AI platform in dentistry.
2025-12
Pearl (via Google Search)
Pearl Receives Industry-First EU-MDR Certification for Second Opinionu00ae AI Platform
Pearl's Second Opinionu00ae chairside dental pathology detection aid received certification as a Class IIa medical device under the European Union Medical Device Regulation (EU-MDR). This makes Pearl the first company in AI-driven computer-aided dental detection software to obtain this certification, reinforcing confidence in its advanced AI solutions for the global dental market.
2023-06
Pearl (via Google Search)
Pearl's Second Opinionu00ae Cleared in Israel, Expanding Global Access to World's Leading Dental AI Technology
Pearl's Second Opinionu00ae received regulatory clearance in Israel, expanding its global presence. The AI platform assists dentists by automatically detecting a broad range of dental conditions in radiographs, leading to more accurate treatment decisions and improved patient trust.
2023-01
Pearl (via Google Search)
Pearl's Second Opinionu00ae Dental AI Platform Cleared in Turkey
Pearl's Second Opinionu00ae received clearance from the Turkish Medicines and Medical Devices Agency (TMMDA) as a Class IIa medical device. This authorization expands the solution's global regulatory clearances and aims to deliver the clinical benefits of AI to one of the fastest-growing dental markets.
2023-10
Dentistry
Saving time, strengthening trust and improving outcomes u2013 the case for AI
An article discusses how Pearl's Second Opinionu00ae AI is transforming clinical workflows in dentistry, improving patient communication, trust, and treatment uptake. Dr. Amanda Bassey-Duke highlights how the system saves an average of nine minutes per appointment and enhances patient understanding through visual aids.
2026-05

Videos

Product demos, reviews, and walkthroughs for Pearl Second Opinion®.

View all on YouTube

Frequently Asked Questions

Pearl Second Opinionu00ae integrates with existing imaging software and practice management systems to provide real-time AI analysis of dental radiographs. It assists in detecting various conditions such as caries, bone loss, calculus, periapical radiolucencies, and existing restorations by highlighting areas of concern with color-coded overlays. This tool is designed to enhance diagnostic accuracy, improve patient communication, and streamline treatment planning, acting as a 'second set of eyes' for the clinician.
Pearl Second Opinionu00ae is FDA-cleared for clinical pathology detection in over 100 countries and is compliant with HIPAA, GDPR, and ISO 13485 standards. Patient data is secured through AES-256 and TLS 1.2/1.3 encryption, and the platform offers configurable data storage options for regional compliance. A PHI button also allows for anonymization of patient names on screen to maintain privacy.
Pearl Second Opinionu00ae operates on a subscription-based model, offering flexible monthly plans and volume-based pricing. There is typically a one-off setup fee that includes integration, training, and support. Practices often report financial benefits through improved efficiency, a reported 37% increase in disease detection, and a 24% higher case acceptance rate, suggesting the software can pay for itself by enhancing diagnostic and treatment outcomes.
Pearl Second Opinionu00ae is an assistive radiologic tool and is not intended for use as a diagnostic device; all final diagnostic decisions must be made by a licensed dental professional. The accuracy of AI detections can vary based on factors like image quality, and some concerns have been raised regarding its FDA clearance for specific functionalities like bone level indication or detailed caries segmentation. Clinicians should critically evaluate AI suggestions and integrate them with their professional judgment.
Pearl Second Opinionu00ae is a leading AI-powered tool focused on chairside detection and patient communication, offering real-time X-ray analysis. Competitors like Overjet also provide AI imaging analysis but often have a broader scope, extending into areas like revenue cycle management and enterprise analytics. Other dental software solutions may offer different integrated features, such as AI chatbots or comprehensive practice management, which differentiate them from Pearl's primary diagnostic focus.
Pearl Second Opinionu00ae primarily analyzes 2D radiographs, including intraoral and panoramic X-rays, for a wide range of pathologies in permanent teeth of patients 12 years and older. Pearl also offers Second Opinion 3Du00ae for automated identification of anatomical structures in CBCT scans. Additionally, Pearl has expanded its capabilities with 'Second Opinion for Kids,' which enhances early decay detection and communication for pediatric patients as young as four.

Related Tools

Detect AI (powered by VideaHealth)
VideaHealth (now Videa)
Dental AI
Detect AI, powered by VideaHealth, integrates FDA-cleared AI into Dentrix practice management to enhance X-ray analysis and caries detection, aiming to improve diagnostic accuracy and treatment acceptance.
Contact for pricing
Overjet Iris Intelligent Imaging System
Overjet, Inc.
Dental AI
Overjet Iris is an FDA-cleared AI-powered dental imaging system that enhances X-ray quality, provides real-time AI analysis for diagnostics, and improves patient communication through visual aids.
SalesCaptain
SalesCaptain
Dental AI
SalesCaptain is an AI-powered customer experience management platform that unifies phone calls, texts, webchat, and social messaging into a single collaborative inbox. It allows businesses to build AI-powered phone and text agents to handle calls, answer queries, route leads, filter spam, and automate tasks, specifically targeting medical and dental practices.
Paid plans start at $159/month.
Fluent Credentialing
Fluent
Credentialing & Enrollment
Fluent Credentialing is a SaaS platform leveraging AI and intelligent workflow automation to modernize and accelerate credentialing across the dental ecosystem, serving payers, DSOs, and providers.
Not published
Dentina.AI
Dentina.AI
Dental AI
Dentina.AI is a 24/7 AI dental receptionist built by a dentist that handles inbound calls, books appointments, and writes results back to the practice management system in real time.
Paid
Curve Care+
Curve Dental
Dental AI
Curve Care+ is an AI-assisted suite embedded in Curve Dental's practice management platform that uses voice commands for clinical notes, charting, and periodontal documentation.
Quote-based

See all Dental AI tools →

More from Pearl

Second Opinion
Pearl
Dental AI
Pearl's Second Opinion is an FDA-cleared AI tool that assists dentists in real-time analysis of dental X-rays, detecting pathologies like caries and bone loss, and enhancing patient communication for improved treatment acceptance.
Subscription-based
Second Opinion CC
Pearl
Dental AI
Pearl's Second Opinion® is an FDA-cleared AI software that assists dentists in interpreting 2D and 3D dental X-rays, detecting a wide range of pathologies with high accuracy, enhancing diagnostic consistency, and improving patient communication and case acceptance.
Subscription-based, starting at $299/month.
Second Opinion Periapical Radiolucency Contours
Pearl
Dental AI
Pearl's Second Opinion AI platform provides advanced segmentation for periapical radiolucency detection, offering precise, AI-generated polygonal contours for enhanced diagnostic accuracy and patient communication.
Starting from $299.00 per month
Second Opinion® 3D
Pearl
Dental AI
Pearl's Second Opinion® 3D is an FDA-cleared AI tool that transforms dental CBCT scans into clear, actionable 3D insights for faster, more accurate diagnoses and treatment planning in dentistry.
Subscription-based

View company profile →

Suggest an Edit → | Last Verified: 2026-04-22 | First Added: 2026-04-22

Investors who backed Pearl Second Opinion®

Funded through the company that built this tool.

Left Lane Capital
VC T1
New York, United States
$5M-$25M
Left Lane Capital is a New York-based growth-equity firm that has built a focused practice around consumer-facing internet and software companies, with…
Care Delivery / Tech-Enabled Services Digital Health
AI Tool Finder
AI-powered search. Results may not be comprehensive.