CINA-VCF

by Avicenna.AI  · Based in France → — Medical Innovation for Enhanced Patient Care
Emergency Medicine Orthopedics Radiology

Contact for pricing
Regulatory Status Disclosed

Overview

Avicenna.AI is a medical AI company specializing in advanced artificial intelligence solutions for emergency radiology and the detection of incidental findings in CT scans. [4, 10, 18] Founded in 2018, the company leverages deep learning and machine learning technologies to develop a suite of AI tools, known as CINA, designed to identify, detect, and quantify severe pathologies within seconds. [4, 9, 15]

CINA-VCF is one such AI-powered triage and notification software. It is specifically indicated for detecting unsuspected vertebral compression fracture (VCF) findings in patients aged 50 years and over undergoing non-enhanced or contrast-enhanced CT scans that include the chest and/or abdomen, regardless of the original clinical indication. [3, 5, 6, 20] The software assists hospital networks and trained medical specialists in workflow triage by flagging and communicating suspected positive findings of VCFs. [20] This early detection is crucial as VCFs, often linked to osteoporosis, can develop silently and significantly increase the likelihood of future fractures if left undiagnosed. [5, 6]

Avicenna.AI’s solutions, including CINA-VCF, are designed to seamlessly integrate into existing clinical workflows, such as PACS and RIS, automatically triggering analysis and reporting algorithm results. [3, 15, 19] This integration aims to optimize care pathways, accelerate therapeutic decision-making, improve patient outcomes, and enhance overall radiology workflow efficiency by reducing interpretation time and alleviating repetitive tasks. [18, 19]

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Detects unsuspected vertebral compression fractures (VCFs)
  • Triage and notification software for VCF findings
  • Analyzes non-enhanced or contrast-enhanced chest and/or abdomen CT scans
  • Prioritizes positive suspected VCF findings
  • Integrates with standard reading environments (PACS, RIS)
  • Deployment options: cloud-based, locally on dedicated hardware, or locally virtualized (VM, Docker)
  • Fast processing time of 10-60 seconds
  • Identifies VCFs in adults aged 50 years and over
  • Outputs results in DICOM SC format
  • CINA-VCF Quantix (Europe only) provides automated intra- and inter-vertebral height loss calculation, vertebral labeling, and color coding by Genant grade

Use Cases

  • Early detection of vertebral compression fractures to prevent complications and improve osteoporosis care
  • Triage and prioritization of patients with suspected VCFs for timely intervention
  • Optimizing radiology workflow by automating VCF detection
  • Reducing interpretation time for CT scans
  • Enhancing patient management and outcomes through faster diagnoses
  • Identifying incidental VCF findings during routine CT scans performed for other indications

What Physicians Need to Know

DICOM Support & Standards
CINA-VCF complies with DICOM (Digital Imaging and Communications in Medicine) standards (NEMA PS 3.1 - 3.20). It accepts DICOM input and provides DICOM SC (Secondary Capture) output.
PACS Integration Method
Integrates into standard reading environments (PACS, RIS) and via AI marketplaces or distribution platforms. It can also function as a standalone third-party application. Avicenna.AI's AVI platform enables native integration with PACS/RIS without requiring additional viewers or workflow changes.
Reading Room Workflow Impact
CINA-VCF is a triage and notification tool designed to detect and prioritize unsuspected vertebral compression fractures (VCFs) on routine CT scans, notifying clinicians within seconds. It aims to facilitate early detection to prevent further bone density loss and complications, enhancing patient care. The AI insights appear automatically within existing diagnostic tools, without requiring new viewers or workflow changes.
AI Model Architecture (deep learning approach)
The algorithm is built on 2D/3D U-Net-based Convolutional Neural Network (CNN) architectures, utilizing deep learning models. It identifies and standardizes the spine, detects and labels thoracic and lumbar vertebrae, and excludes vertebrae with cement or other materials. The models were trained on a dataset of 886 cases (12,402 vertebrae) from multiple centers and scanner manufacturers.
Processing Speed (per study)
The processing time per study is between 10 and 60 seconds, with notifications delivered to clinicians within seconds.
FDA Clearance Pathway (510k/De Novo)
CINA-VCF received 510(k) clearance from the U.S. FDA in June 2024, classifying it as a Class II medical device.
Supported Modalities (CT/MRI/X-ray/US)
Supports CT scans, specifically chest or abdomen CT scans (with or without contrast) performed for any clinical indication, in patients aged 50 years and over.
Sensitivity & Specificity Data
Validated on 474 CT scans, achieving excellent sensitivity and specificity. One study reported a sensitivity of 92.3% and specificity of 91.7%. Another study showed a sensitivity of 92% (95% CI 82u201397%), specificity of 99% (95% CI 93u2013100%), and overall accuracy of 96% (95% CI 92u201399%) for VCF detection. Avicenna.AI reports a sensitivity of 95.2%, specificity of 92.9%, and accuracy of 93.7% for CINA-VCF.
RSNA/ACR Validation
The tool's compliance with DICOM standards (developed by ACR and NEMA) indicates adherence to recognized industry standards. Validation studies have been published in peer-reviewed journals, including 'Validation of a Deep Learning Tool for Detection of Incidental Vertebral Compression Fractures' in the Journal of Computer Assisted Tomography (Jan 2025).
Physician Tip

CINA-VCF serves as an opportunistic screening tool, flagging potential vertebral compression fractures on routine chest or abdomen CTs, which are often missed. While it provides rapid triage and notification, remember that it is a computer-aided triage and notification software, not a diagnostic device. Always integrate its findings with comprehensive patient information and your professional judgment. The seamless integration into existing PACS/RIS through platforms like AVI means minimal disruption to your current workflow, allowing AI insights to appear automatically without additional clicks or new interfaces.

CINA-VCF is designed for seamless integration into existing radiology ecosystems. It supports DICOM for image input and output (DICOM SC) and can integrate directly with PACS and RIS. Deployment options include cloud-based, local dedicated hardware, or local virtualized environments (VM, Docker). Avicenna.AI's AVI platform further streamlines integration, offering a single point of access for Avicenna's AI portfolio and ensuring compatibility with global standards like DICOM, HL7, and FHIR, minimizing IT overhead and workflow disruption.

Details

Category Radiology & Imaging AI, Triage & ER/ICU AI
Pricing Contact for pricing — Subscription-based; pricing based on number of installations and number of users. [3, 10]
DeploymentCloud-based, Locally on dedicated hardware, Locally virtualized (virtual machine, Docker)
Compliance
BAA AvailableUnknown AI-estimated
HIPAA Compliant Yes AI-estimated
FDA Status 1 AI-estimated

CINA-VCF received 510(k) clearance from the U.S. Food and Drug Administration (FDA) on May 31, 2024. It is classified as a Class II radiological computer-assisted triage and notification software.

Integrations
EHR Not specified
Specialties Emergency Medicine, Orthopedics, Radiology

Ratings & Reviews

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Clinical Value
Ease of Use
Integration
Support & Docs
Value for Money

Press & Coverage

PR Newswire
Avicenna.AI Secures CE Mark for Two Spine-Focused Medical Imaging AI Tools
Avicenna.AI announced CE Mark certification for CINA-VCF Quantix, an AI algorithm for detecting and assessing unsuspected vertebral compression fractures (VCFs), and CINA-CSpine for cervical spine fracture detection, enabling their deployment across the European Economic Area.
2025-06
AuntMinnie
FDA clears Avicenna.AI's fracture detection software - AuntMinnie
Avicenna.AI received U.S. FDA clearance for CINA-VCF, an AI tool designed to detect vertebral compression fractures in patients undergoing chest or abdomen CT scans for other conditions.
2024-06
Applied Radiology
FDA Clears Avicenna.AI Solution for Detection of Vertebral Compression Fractures
Avicenna.AI's CINA-VCF, an AI tool for detecting unsuspected vertebral compression fractures (VCFs) in CT scans, has received FDA 510(k) clearance, aiming to improve early detection and patient outcomes for a condition often linked to osteoporosis.
2024-06
BioWorld
FDA clears Avicenna algorithm to detect cervical spine fractures | BioWorld
Avicenna.AI's CINA-VCF, which detects unsuspected vertebral compression fractures, received FDA clearance in June 2024, adding to the company's growing list of FDA-cleared AI algorithms for various conditions.
2024-09
Medical Imaging AI
Avicenna.AI Launches AVI Platform | Medical Imaging AI
Avicenna.AI launched its AVI Platform, a new system designed to seamlessly integrate AI results into healthcare ecosystems, providing access to its entire CINA portfolio, including CINA-VCF and CINA-VCF Quantix for vertebral compression fractures.
2025-11
Clinical Radiology (Avicenna.AI Clinical Publications)
Automated vertebral compression fracture detection and quantification on opportunistic CT scans: A performance evaluation
A peer-reviewed publication from 2025 details the performance evaluation of CINA-VCF Quantix for automated vertebral compression fracture detection and quantification on opportunistic CT scans.
2025
EMJ (European Medical Journal)
New AI System Detects Spinal Fractures with 64% Accuracy: WCO 2025 - EMJ
A multicenter evaluation study presented at WCO 2025 highlighted that Avicenna.AI's CINA-VCF Quantix significantly improved the detection of osteoporotic vertebral compression fractures, with nearly a third of AI-detected fractures missed in original radiology reports.
2025-05
PMC (PubMed Central)
Deep learning-driven incidental detection of vertebral fractures in cancer patients: advancing diagnostic precision and clinical management - PMC
This study, published in August 2025, assesses the diagnostic performance of Avicenna.AI's CINA-VCF Quantix for VCF detection and quantification in asymptomatic oncology patients undergoing CT imaging.
2025-08

Videos

Product demos, reviews, and walkthroughs for CINA-VCF.

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Frequently Asked Questions

CINA-VCF is an AI-powered triage and notification software designed to integrate into standard reading environments like PACS or RIS. It analyzes chest and/or abdominal CT scans, identifying unsuspected vertebral compression fractures and providing rapid notifications to help prioritize cases for radiologist review.
CINA-VCF has received FDA 510(k) clearance in the United States. While specific details on data security protocols beyond standard integration are not explicitly detailed in the provided snippets, AI tools in healthcare are generally expected to adhere to regulations like HIPAA for patient data privacy and security.
CINA-VCF has demonstrated high sensitivity (94.4%) and specificity (88.7%) in detecting vertebral compression fractures. It is a triage and notification tool, not a diagnostic device, meaning its findings are intended to assist with prioritization and require full review and professional judgment by the clinician.
By identifying often-missed vertebral compression fractures on routine CT scans, CINA-VCF can facilitate earlier diagnosis of conditions like osteoporosis. This early detection can lead to timely treatment, potentially preventing further fractures, reducing complications, and improving long-term patient mobility and quality of life.
Yes, other AI solutions exist, such as Nanox.AI's Healthvcf software, which also detects VCFs from routine CT scans. CINA-VCF, developed by Avicenna.AI, focuses on triage and notification, aiming to accelerate the detection and prioritization of these fractures within the existing workflow.
The specific pricing model for CINA-VCF is not detailed in the provided information. However, such AI solutions are typically acquired by healthcare institutions through direct vendor agreements, AI marketplaces, or distribution platforms, often involving licensing fees or subscription models.

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Suggest an Edit → | Last Verified: 2026-04-17 | First Added: 2026-04-17
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